Home Objective Mobility Exam (HOME) for Balance and Gait Disorders in Parkinson's

主页针对帕金森病平衡和步态障碍的目标行动能力检查 (HOME)

基本信息

批准号：
8519026
负责人：
Mahmoud El-Gohary
金额：
$ 34.98万
依托单位：
APDM, INC.
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-06-01 至 2015-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8519026
关键词：
Biomedical Engineering Blood Pressure Cardiac Characteristics Charge Chronic Clinic Clinic Visits Clinical Clinical Research Clinical assessments Collection Computers Craniocerebral Trauma Data Data Analyses Development Disease Disease Progression Docking Early Intervention Equilibrium Exercise Frail Elderly Funding Gait Gait abnormality Goals Hand Home environment Human Intervention Investments Leg Marketing Measures Medical Methods Monitor Movement Movement Disorders Multiple Sclerosis Neurosciences Parkinson Disease Patients Pharmaceutical Preparations Phase Physical therapy Physicians Preparation Prevention Research Research Personnel Risk Assessment Secure Self Assessment Self-Administered Stroke System Technology Testing Time Training Validity and Reliability Walking Wireless Technology aging population base clinical decision-making data management design developmental disease disability equilibration disorder fall risk falls gait examination improved innovation interest laptop multisensory nervous system disorder novel prevent public health relevance sensor tool treatment as usual

项目摘要

DESCRIPTION (provided by applicant): Although balance and gait disorders are one of the most common and devastating chronic medical problems of older people, especially those with chronic neurological diseases, clinicians or clinical researchers do not measure balance and gait frequently, accurately, or sensitively. Our long-term goal is to develop and commercialize a unique system called the Home Objective Mobility Exam (HOME) to allow patients to measure their own balance and gait at home. If physicians and physical therapists could obtain frequent, accurate, self-administered measures of balance and gait characteristics, then they will be able to earlier predict fall risk and changes in mobility. This will also enable them to quickly improve interventions in order to prevent mobility disability. The objective of this application is to deveop a novel method to allow patients to quantify their own standing balance, gait and turning with a quick, simple, and extremely easy to use system. The specifc aims are: Aim I. To develop a new version of the Opal movement monitor for home use. The objective of this aim is to transform the Opal sensors from a computer-based clinician/researcher-controlled system to a nonprofessional/patient-controlled system of movement monitoring. Aim II. To determine the feasibility, validity and reliability of having people with Parkinson's disease test their own balance and gait at home. We hypothesize that balance and gait, measured by patients in their homes, will be valid and reliable compared with measures administered by research assistants and with clinical scales and show very good test-retest reliability. We will initially develop HOME for patients with Parkinson's disease because they have more falls than any other neurological disorder, but we are confident that this tool will be useful for patients any form of mobility disability, such as multiple sclerosis, stroke, head injury, developmental disorders, multisensory deficits, frail elderly, etc. Based on results of this proposal, our Phase II application will thentest the ability of the HOME to more quickly detect changes in balance and gait following a change in medication or physical therapy, compared to usual care, in preparation for FDA approval and widespread marketing.

描述（由申请人提供）：虽然平衡和步态障碍是老年人（尤其是患有慢性神经系统疾病的老年人）最常见和最具破坏性的慢性医疗问题之一，但临床医生或临床研究人员并没有频繁、准确或灵敏地测量平衡和步态。我们的长期目标是开发一种名为“家庭目标行动能力检查”(HOME) 的独特系统并将其商业化，让患者能够在家中测量自己的平衡和步态。如果医生和物理治疗师能够获得频繁、准确、自我管理的平衡和步态特征测量，那么他们将能够更早地预测跌倒风险和活动能力的变化。这也将使他们能够快速提高预防行动障碍的干预措施。该应用程序的目标是开发一种新颖的方法，让患者能够通过快速、简单且极其易于使用的系统来量化自己的站立平衡、步态和转身。具体目标是：目标 I. 开发新版本的家用 Opal 运动监视器。这一目标的目的是将 Opal 传感器从基于计算机的临床医生/研究人员控制系统转变为非专业/患者控制的运动监测系统。目标二。确定让帕金森病患者在家测试自己的平衡和步态的可行性、有效性和可靠性。我们假设，与研究助理和临床量表进行的测量相比，患者在家中测量的平衡和步态将是有效和可靠的，并且显示出非常好的重测可靠性。我们将首先开发HOME 对于帕金森病患者来说，因为他们比任何其他神经系统疾病患者跌倒的次数都多，但我们相信该工具对于任何形式的行动障碍患者都有用，例如多发性硬化症、中风、头部损伤、发育障碍、多感觉缺陷、根据该提案的结果，我们的第二阶段应用程序将测试 HOME 与常规护理相比，更快地检测药物或物理治疗变化后平衡和步态变化的能力，为 FDA 做准备赞同以及广泛的营销。