MESOCORTICAL ANATOMY AND PLASTICITY

中皮质解剖学和可塑性

• 批准号: 3395852
• 负责人: GARY W VAN HOESEN
• 金额: $ 8.65万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 1979
• 资助国家: 美国
• 起止时间: 1979-01-01 至 1989-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3395852
• 关键词: Macaca; Macaca mulatta; amygdala; association cortex; autoradiography; axon; brain interhemispheric activity; cerebral cortex; fluorescent dye /probe; hippocampus; histochemistry /cytochemistry; innervation; limbic system; microscopy; neural plasticity; neuroanatomy; olfactory lobe; radionuclide double label

This application outlines a continuing (years 7-9) research plan designed to elucidate the neuroanatomical organization of the corices (mesocortices) that form the so-called limbic lobe in the old-world monkey. The mesocortices form a large part of the cortex on the medial surface of the cerebral hemisphere, and well-know areas like the cingulate gyrus, parahippocampal gyrus, posterior orbitofrontal area and temporal polar area are major elements. The major long term goal is to understand their relationship with the neocortex. Three continuing aims are outlined: (1) the first, and major aim entails experimental neuroanatomical studies on the connections of the mesocortices using anterograde and retrograde tracing techniques, (2) the second aim centers around light microscopic reinnervation studies in deep temporal lobe structures like the amygdala, (3) the third aim is represented by studied that assess axon collateralization in mesocortica connections using fluorexcent double-labeling techniques. Connection studies address the intrinsic and commissural projection of the mesocortices, reinnervation studies focus on the lateral amygdaloid nucleus and double-labeling studies assess axon collateralization in the posterior parahippocampal, cingulate and orbito-frontal areas. The research has basic as well as clinical neuroscience relevance. The mesocortices are connectionally and architecturally intermediate in structure, sharing the features of interconnecting the association cortices with the limbic system. When this relationship is disrupted in neurological disease debilitating disorders relating to memory, attention and emotion results. The reinnervation studies focus on temporal lobe areas involved frequently in head trauma and hold relevance to post-traumatic changes in behavior seen frequently in the clinical setting. To conserve costs the individual investigations are designed in an interlocking fashion and draw in part on a collection of non-human primate material gathered over the past 15 years at Harvard Medical School (1969-1978) and the University of Iowa (1979-1984). None of the proposed investigations rely exclusively on the generation of all new research material.

该应用程序概述了持续的（7-9年）研究计划 阐明珊瑚的神经解剖组织（中皮） 这形成了旧世界猴子中所谓的边缘叶。 这 中皮质构成了大部分皮质的内侧表面上的皮层 脑半球和诸如扣带回的众所周知的区域， parahampocampal回，后轨道额和颞极区域 是主要要素。 主要的长期目标是了解他们 与新皮层的关系。 概述了三个持续的目标：（1） 首先，主要目的是关于实验性神经解剖学研究 使用顺序和逆行的介质的连接 追踪技术，（2）第二个目标围绕光显微镜 在深颞叶结构等深层片状结构中的重新支配研究，如杏仁核， （3）第三个目标由评估轴突的研究表示 使用荧光的中色皮质连接中的抵押 双标记技术。 连接研究涉及内在和 中皮皮质的合理投影，重新培养研究的重点 外侧杏仁核核和双标记研究评估轴突 后副群，扣带和 Orbito-Frontal地区。 该研究具有基本和临床 神经科学相关性。 中皮质质是连接的， 结构上的建筑中间，共享 将关联皮层与边缘系统互连。 当这个 神经疾病使人衰弱的疾病破坏了关系 与记忆，注意力和情感结果有关。 重新支配 研究重点是颞叶区域，经常参与头部创伤和 与经常在行为创伤后的行为变化有关 临床环境。 为了节省成本，个人调查是 以互锁的方式设计，部分借鉴了 在过去的15年中，非人类灵长类动物材料聚集在哈佛 医学院（1969-1978）和爱荷华大学（1979-1984）。 没有 拟议的调查仅依赖于所有新的生成 研究材料。