EXPERIMENTAL NEUROANATOMY OF SYSTEMS RELATED TO COGNITION

与认知相关的系统的实验神经解剖学

• 批准号: 6219162
• 负责人: GARY W VAN HOESEN
• 金额: $ 2.33万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-07-01 至 2000-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6219162
• 关键词: Alzheimer's disease; Gorillas; Macaca mulatta; Pan; Pongidae; Pongo; autogenic training; axon; brain mapping; cerebral cortex; clinical research; cognition; emotions; entorhinal cortex; hippocampus; human subject; human tissue; immunocytochemistry; memory; neuroanatomy; neuropsychology; somesthetic sensory cortex; species difference; stainings; visual perception

This project is designed to investigate several novel aspects of the anatomical organization and pathology of the cerebral cortex which are directly relevant to cognitive functions. The issues addressed here follow directly on questions raised in other projects of this Program, especially on those pertaining to the neural basis of memory. The research is aimed at providing neuroanatomical characterizations of: (a) connectional links within specified cortical systems, and (b) the intrinsic structure of cortical regions participating in these systems. Such information is critical for the interpretation of experimental results based on any of the currently available approaches to the neurological basis of cognition in humans (e.g. the lesion method, PET, electrophysiology), and for the continued evaluation of theoretical formulations regarding the neural architecture and operations that may subserve cognition in primates. The proposal is divided into three subprojects: (1) high resolution tracing of connections from the parahippocampal cortex in monkeys, (2) topography of the human perforant pathway, and (3) modular organization of the human entorhinal cortex. Each subproject is based on a combination of modern histo- and immunocytochemical methods and conventional histology, to permit the dissection of chemically identified neurons and/or neurites. The information obtained from these tightly interrelated projects will contribute to a better understanding of the substrates of both normal and disordered human cognition at the cellular and connectional levels, and to a characterization of their alteration in conditions such as Alzheimer's disease.

该项目旨在研究该项目的几个新颖方面 大脑皮层的解剖组织和病理学 与认知功能直接相关。 这里解决的问题如下 直接回答本计划其他项目中提出的问题，特别是 与记忆的神经基础有关的内容。 研究目的是 提供以下神经解剖学特征： (a) 连接链接 在特定的皮质系统内，以及（b）的内在结构 参与这些系统的皮质区域。 此类信息是 对于基于任何一个的实验结果的解释至关重要 目前可用的认知神经学基础方法 人类（例如病变法、PET、电生理学），以及 继续评估有关神经网络的理论公式 可能有助于灵长类动物认知的架构和操作。 这 提案分为三个子项目：（1）高分辨率追踪 猴子海马旁皮层的连接，（2）地形 人类穿通通路，以及（3）人类的模块化组织 内嗅皮层。 每个子项目都基于现代技术的结合 组织化学和免疫细胞化学方法以及常规组织学，以允许 化学鉴定的神经元和/或神经突的解剖。 这 从这些紧密相关的项目中获得的信息将 有助于更好地了解正常和 在细胞和连接水平上扰乱人类认知，并 他们在阿尔茨海默病等疾病中的改变的特征 疾病。