EXPERIMENTAL NEUROANATOMY OF SYSTEMS RELATED TO COGNITION

与认知相关的系统的实验神经解剖学

• 批准号: 5215163
• 负责人: GARY W VAN HOESEN
• 金额: --
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/5215163
• 关键词: Alzheimer's disease; Gorillas; Macaca mulatta; Pan; Pongidae; Pongo; autogenic training; axon; brain mapping; cerebral cortex; clinical research; cognition; emotions; entorhinal cortex; hippocampus; human subject; human tissue; immunocytochemistry; memory; neuroanatomy; neuropsychology; somesthetic sensory cortex; species difference; stainings; visual perception

This project is designed to investigate several novel aspects of the anatomical organization and pathology of the cerebral cortex which are directly relevant to cognitive functions. The issues addressed here follow directly on questions raised in other projects of this Program, especially on those pertaining to the neural basis of memory. The research is aimed at providing neuroanatomical characterizations of: (a) connectional links within specified cortical systems, and (b) the intrinsic structure of cortical regions participating in these systems. Such information is critical for the interpretation of experimental results based on any of the currently available approaches to the neurological basis of cognition in humans (e.g. the lesion method, PET, electrophysiology), and for the continued evaluation of theoretical formulations regarding the neural architecture and operations that may subserve cognition in primates. The proposal is divided into three subprojects: (1) high resolution tracing of connections from the parahippocampal cortex in monkeys, (2) topography of the human perforant pathway, and (3) modular organization of the human entorhinal cortex. Each subproject is based on a combination of modern histo- and immunocytochemical methods and conventional histology, to permit the dissection of chemically identified neurons and/or neurites. The information obtained from these tightly interrelated projects will contribute to a better understanding of the substrates of both normal and disordered human cognition at the cellular and connectional levels, and to a characterization of their alteration in conditions such as Alzheimer's disease.

该项目旨在调查该项目的几个新颖方面 大脑皮层的解剖组织和病理 与认知功能直接相关。 这里解决的问题如下 直接在该计划的其他项目中提出的问题，尤其是 关于与记忆的神经基础有关的人。 这项研究针对 在提供：（a）连接链接的神经解剖学特征方面 在指定的皮质系统中，（b） 参加这些系统的皮质区域。 这样的信息是 基于任何一个 目前可用的方法在 人类（例如，病变方法，PET，电生理学），用于 继续评估有关神经的理论表述 可能会在灵长类动物中提供认知的建筑和操作。 这 提案分为三个副本：（1）高分辨率跟踪 来自猴子的帕拉希波克省皮质的连接，（2）地形 人类的穿孔途径和（3）人类的模块化组织 内河皮质。 每个子标记都是基于现代的组合 组织和免疫细胞化学方法和常规组织学，以允许 化学鉴定的神经元和/或神经突的解剖。 这 从这些紧密相互关联的项目获得的信息将 有助于更好地理解正常和正常的底物 在细胞和连接水平上的人类认知无序，以及 在阿尔茨海默氏症等条件下改变其改变的特征 疾病。