Experimental neuroanatomy of systems related to emotion

情绪相关系统的实验神经解剖学

• 批准号: 6597652
• 负责人: GARY W VAN HOESEN
• 金额: $ 11.03万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-07-01 至 2003-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6597652
• 关键词: Macaca; brain mapping; cingulate gyrus; emotions; hippocampus; neural information processing; neuroanatomy; neuropsychology; temporal lobe /cortex

This project outlines an experimental neuroanatomical investigation on the monkey designed to assess the cortical and subcortical connectivity of the cingulate cortex. In close articulation with other components of the Program, the new effort represents a shift from our focus on the temporal lobe and issues pertaining to memory. We have set the stage for this shift with studies linking temporal structures to anterior cingulate cortices, and defining the interface between the posterior parahippocampal gyrus and the perisplenial cortices. In the forthcoming funding period we plan to carry out a number of studies aimed at elucidating, in greater detail than what is currently available, the connectivity of the cingulate cortex, a major function of which is the processing of emotion and feeling. These investigations will test the hypothesis that varied subdivisions of the cingulate cortex have distinct patterns of connectivity with subcortical an cortical structures. In fact, there is classic evidence that the primate cingulate cortex consists of cytoarchitectonically distinct subdivisions with other brain regions. This gap seriously limits the formulation of hypothesis in the study of cognition and emotion and the interpretation of current experimental results. Our aim is to bridge this gap by assessing the efferent and afferent connections of each cingulate subdivisions in the monkey using multiple injections of anterograde and retrograde tracers. Particular attention will be paid to subcortical connections since they have been sparsely studied in primates. Additionally, our data will reveal in detail the nature of intracingualte connectivity. The results of our proposed studies will provide a basis for understanding the neuroanatomical correlates of neurological conditions that have altered emotional states as salient clinical manifestations, and will aid in updating and extending theoretical formulations concerning the brain systems underlying complex cognition and behavior in humans, especially emotional processing and decision making. Our new direction is of direct relevance to other projects in the Program which deal with emotion, decision making and development (projects 1, 4 and 5).

该项目概述了对猴子的实验性神经解剖学研究，旨在评估扣带回皮质的皮质和皮质下连通性。在与该程序的其他组成部分的密切阐述中，新的努力代表了我们对颞叶的关注和与内存有关的问题的转变。我们已经与将时间结构与前扣带回皮质联系起来的研究为这一转变设定了阶段，并定义了后parahampocampal回和周围的皮质皮质之间的界面。在即将到来的资金期间，我们计划进行多项研究，旨在阐明比目前可用的扣带回皮质的连通性更详细的研究，其中主要功能是情感和感觉的处理。这些研究将检验以下假设：扣带回皮质的各种细分具有与皮层下皮质结构的连通性不同的模式。实际上，有经典的证据表明，灵长类动物的扣带皮层由与其他大脑区域的细胞结构不同的细分组成。这一差距严重限制了在认知和情感研究中的假设以及当前实验结果的解释。我们的目的是通过评估猴子在猴子中每个扣带动分区的侵蚀和传入连接的弥合差距，并使用多次注射顺行和逆行示踪剂。由于在灵长类动物中稀少研究，因此特别关注皮层连接。此外，我们的数据将详细揭示上文中连接性的性质。我们提出的研究的结果将为理解神经系统状况的神经解剖学相关性提供基础，这些神经系统状况改变了情绪状态作为显着的临床表现，并将有助于更新和扩展有关人类基础的大脑系统，尤其是人类行为的理论表述，尤其是人类的理论表现。情绪处理和决策。我们的新方向与该计划中的其他项目直接相关，该项目处理情感，决策和发展（项目1、4和5）。