Integration of social and nonsocial information in the primate brain

灵长类大脑中社交和非社交信息的整合

• 批准号: 10541330
• 负责人: Joseph Simon
• 金额: $ 4.78万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10541330
• 关键词: Advanced Development; Anatomy; Anterior; Area; Behavior; Brain; Brain Mapping; Brain region; Characteristics; Clinical; Code; Cognitive; Complex; Computer Analysis; Computer Models; Cues; Data; Decision Making; Diagnostic and Statistical Manual of Mental Disorders; Disease; Distress; Environment; Epilepsy; Exhibits; Eye; Eye Movements; Face; Fellowship; Foundations; Future; Goals; Human; Impaired cognition; Impairment; Juice; Knowledge; Label; Learning; Location; Macaca mulatta; Medial; Mental Depression; Mental Health; Mental disorders; Methods; Modeling; Monkeys; Motor; Nature; Neuroanatomy; Neurobiology; Neurons; Neurophysiology - biologic function; Neurosciences; Pathologic; Patients; Phase; Primates; Process; Research; Research Personnel; Rewards; Rodent; Saccades; Schizophrenia; Signal Transduction; Site; Social Behavior; Social Environment; Social Functioning; Social Interaction; Social status; Stimulus; Study Subject; Study models; Testing; Therapeutic; Tissues; Training; Visual; Visual Perception; Work; autism spectrum disorder; career; cingulate gyrus; cognitive control; design; frontal eye fields; frontal lobe; gaze; human subject; improved; insight; mental health related disorder; multimodality; neural circuit; neuromechanism; neurophysiology; next generation; nonhuman primate; novel; novel strategies; relating to nervous system; response; social; social cognition; social group; social integration; social neuroscience; tool

Project Summary Primate species frequently use social information to inform their decisions, for instance, to help make inferences about potential threats or rewards in the environment. The Diagnostics and Statistical Manual for Mental Disorders (DSM) has labeled social impairments, including social cognition, as a primary characteristic of many mental health-related disorders, including Autism Spectrum Disorder and Schizophrenia. Therefore, understanding the neurobiology surrounding social cognition and decision-making is of critical importance. Work in this field has primarily centered around human and rodent studies, mapping brain regions related to social cognition and innate social functions. To understand the neural mechanisms governing complex social reasoning, however, we must investigate neural circuit function in primate brains. Neurophysiology recording in monkeys, particularly rhesus macaque, provide us with an ideal model to investigate these questions. Rhesus monkeys are a social species with similar neuroanatomy to humans and engage in complex social behaviors. Thus, they can provide valuable insight to the mechanisms of social cognition in the brain. The long-term goal of this project is to determine whether the brain encodes social information in multimodal circuits, or if social information is encoded in a fundamentally unique way. In the following proposal, I detail how monkeys are an ideal model to study social cognition using a neurophysiological approach. In Aim 1, I have taught monkeys to use social and nonsocial visual guides to select correct target locations for a juice-reward. In the F99-phase, I will record and analysis neurons from the anterior cingulate gyrus (ACCg) and the frontal eye field (FEF), interconnected regions implicated in social cognition and motor planning, to determine how this circuit encodes goal-directed information derived from social and nonsocial cues. In Aim 2, under the K00 phase, I discuss my proposal for a multi-subject study incorporating neurophysiological recording and computational modeling and analysis to understand how neural activity facilitates social interactive behavior. Overall, my goal for this fellowship is to provide myself with the tools, knowledge, and ability to successfully make a lasting impact on the neuroscience field and improve our knowledge of how social cognition impacts our mental health.

项目摘要 灵长类动物经常使用社会信息来告知他们的决定，以帮助做出推断 关于环境中的潜在威胁或奖励。精神的诊断和统计手册 疾病（DSM）将社会障碍（包括社会认知）标记为许多人的主要特征 与心理健康有关的疾病，包括自闭症谱系障碍和精神分裂症。所以， 了解围绕社会认知和决策的神经生物学至关重要。工作 在这个领域，主要围绕着人类和啮齿动物研究，绘制与社会有关的大脑区域 认知和先天的社会功能。了解有关复杂社会的神经机制 但是，推理我们必须研究灵长类动物大脑中的神经回路功能。神经生理记录 猴子，尤其是恒河猕猴，为我们提供了一个理想的模型来研究这些问题。恒河 猴子是一种社会物种，具有与人类类似的神经解剖学，并从事复杂的社会行为。 因此，他们可以为大脑中社会认知机制提供宝贵的见解。长期目标 这个项目的是确定大脑是否在多模式电路中编码社会信息，还是社会的 信息以根本独特的方式编码。在以下建议中，我详细介绍了猴子是如何 使用神经生理学方法研究社会认知的理想模型。在AIM 1中，我教猴子 使用社交和非社会视觉指南为果汁奖励选择正确的目标位置。在F99阶段，我 将记录和分析来自前扣带回回（ACCG）和额眼场（FEF）的神经元， 与社会认知和运动计划有关的互连区域，以确定该电路如何编码 目标定向的信息来自社会和非社会提示。在AIM 2中，在K00阶段，我讨论了我的 一项包含神经生理记录和计算建模和计算建模的多主体研究的建议 分析以了解神经活动如何促进社会互动行为。总的来说，我的目标 奖学金是为自己提供工具，知识和能力，以成功地对此产生持久影响 神经科学领域并提高了我们对社会认知如何影响我们心理健康的了解。