Integration of social and nonsocial information in the primate brain

灵长类大脑中社交和非社交信息的整合

基本信息

批准号：
10541330
负责人：
Joseph Simon
金额：
$ 4.78万
依托单位：
ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-09-01 至 2024-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10541330
关键词：
Advanced Development Anatomy Anterior Area Behavior Brain Brain Mapping Brain region Characteristics Clinical Code Cognitive Complex Computer Analysis Computer Models Cues Data Decision Making Diagnostic and Statistical Manual of Mental Disorders Disease Distress Environment Epilepsy Exhibits Eye Eye Movements Face Fellowship Foundations Future Goals Human Impaired cognition Impairment Juice Knowledge Label Learning Location Macaca mulatta Medial Mental Depression Mental Health Mental disorders Methods Modeling Monkeys Motor Nature Neuroanatomy Neurobiology Neurons Neurophysiology - biologic function Neurosciences Pathologic Patients Phase Primates Process Research Research Personnel Rewards Rodent Saccades Schizophrenia Signal Transduction Site Social Behavior Social Environment Social Functioning Social Interaction Social status Stimulus Study Subject Study models Testing Therapeutic Tissues Training Visual Visual Perception Work autism spectrum disorder career cingulate gyrus cognitive control design frontal eye fields frontal lobe gaze human subject improved insight mental health related disorder multimodality neural circuit neuromechanism neurophysiology next generation nonhuman primate novel novel strategies relating to nervous system response social social cognition social group social integration social neuroscience tool

项目摘要

Project Summary Primate species frequently use social information to inform their decisions, for instance, to help make inferences about potential threats or rewards in the environment. The Diagnostics and Statistical Manual for Mental Disorders (DSM) has labeled social impairments, including social cognition, as a primary characteristic of many mental health-related disorders, including Autism Spectrum Disorder and Schizophrenia. Therefore, understanding the neurobiology surrounding social cognition and decision-making is of critical importance. Work in this field has primarily centered around human and rodent studies, mapping brain regions related to social cognition and innate social functions. To understand the neural mechanisms governing complex social reasoning, however, we must investigate neural circuit function in primate brains. Neurophysiology recording in monkeys, particularly rhesus macaque, provide us with an ideal model to investigate these questions. Rhesus monkeys are a social species with similar neuroanatomy to humans and engage in complex social behaviors. Thus, they can provide valuable insight to the mechanisms of social cognition in the brain. The long-term goal of this project is to determine whether the brain encodes social information in multimodal circuits, or if social information is encoded in a fundamentally unique way. In the following proposal, I detail how monkeys are an ideal model to study social cognition using a neurophysiological approach. In Aim 1, I have taught monkeys to use social and nonsocial visual guides to select correct target locations for a juice-reward. In the F99-phase, I will record and analysis neurons from the anterior cingulate gyrus (ACCg) and the frontal eye field (FEF), interconnected regions implicated in social cognition and motor planning, to determine how this circuit encodes goal-directed information derived from social and nonsocial cues. In Aim 2, under the K00 phase, I discuss my proposal for a multi-subject study incorporating neurophysiological recording and computational modeling and analysis to understand how neural activity facilitates social interactive behavior. Overall, my goal for this fellowship is to provide myself with the tools, knowledge, and ability to successfully make a lasting impact on the neuroscience field and improve our knowledge of how social cognition impacts our mental health.

项目概要灵长类动物经常使用社会信息来告知他们的决定，例如，帮助做出推论关于环境中的潜在威胁或奖励。心理诊断与统计手册疾病 (DSM) 将社会障碍（包括社会认知）标记为许多人的主要特征心理健康相关疾病，包括自闭症谱系障碍和精神分裂症。所以，了解围绕社会认知和决策的神经生物学至关重要。工作该领域主要围绕人类和啮齿动物研究，绘制与社交相关的大脑区域图认知和先天的社会功能。了解控制复杂社会的神经机制然而，为了推理，我们必须研究灵长类动物大脑中的神经回路功能。神经生理学记录猴子，特别是恒河猴，为我们提供了研究这些问题的理想模型。恒河猴猴子是一种社会物种，其神经解剖结构与人类相似，并且具有复杂的社会行为。因此，它们可以为大脑中的社会认知机制提供有价值的见解。长期目标该项目的目的是确定大脑是否在多模态回路中编码社交信息，或者社交信息是否被编码。信息以一种根本上独特的方式编码。在下面的提案中，我详细说明了猴子是如何使用神经生理学方法研究社会认知的理想模型。在目标 1 中，我教猴子使用社交和非社交视觉指南来选择正确的目标位置以获得果汁奖励。在F99阶段，我将记录和分析来自前扣带回（ACCg）和额眼场（FEF）的神经元，涉及社会认知和运动规划的互连区域，以确定该电路如何编码来自社交和非社交线索的目标导向信息。在目标 2 中，在 K00 阶段，我讨论了我的结合神经生理学记录和计算模型的多主题研究提案分析以了解神经活动如何促进社交互动行为。总的来说，我的目标是奖学金的目的是为自己提供工具、知识和能力，以成功地对社会产生持久的影响神经科学领域并提高我们对社会认知如何影响我们的心理健康的了解。