SOMATIC SYMPTOMS AND THE PSYCHOBIOLOGY OF ANXIETY

躯体症状和焦虑的心理生物学

• 批准号: 3381779
• 负责人: Rudolf Franz Walter Hoehn-Saric
• 金额: $ 6.1万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-03-01 至 1989-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3381779
• 关键词: anxiety; arousal; autonomic nervous system; benzodiazepines; dosage; heart disorder; human subject; mental disorder chemotherapy; patient monitoring device; psychophysiology; psychosomatic disorders; sign /symptom; stress; sweat

In anxiety disorders, the selection and assessment of treatment depend to a large extent on patient reports of somatic symptomatology. It is important, therefore to obtain a better understanding of the relationships between patient reports and actual underlying physiological activity. In general, self reports and physiological measures do not correlate very well. Among the possible reasons for this finding is that the physiological measures have been taken in laboratory settings rather than during patients' usual daily activities. The construction of an ambulatory monitoring device is proposed as a means of recording skin conductance, heart rate, respiration and activity levels while patients go about their daily life activities. In a past study we found that although correlations between self report and physiology are low, patients are able to perceive the direction of changes in physiologcial activity under stress. In another study we found that patients with high levels of autonomic arousal differ on several somatic ratings from patients with low levels. In still another study we have found that patients with high ratings of autonomic symptomatology require higher doses of alprazolam for treatment than do those with low ratings. In the proposed study, we wish to determine whether patients with high and low levels of autonomic symptomatology differ in underlying physiological activity. Two groups of patients, one with and one without high levels of sympathetic nervous system activity, will be compared by means of the ambulatory monitoring device. Specifically, 32 patients who do, and 32 who do not, present with heart palpitations and sweaty palms will wear the ambulatory monitoring device for 8 hours of recording. They will rate their symptoms throughout the day and comparisons will be made between the physiological recordings of the two groups and between the self reported symptoms and physiological recordings of two groups under different levels of perceived stress. Data from the study will allow us to determine whether patients who report different sets of symptoms differ in underlying physiological activity, and whether self reports of somatic symptoms correlate with actual physiologcial measures during patients' everyday activities.

在焦虑症中，选择和评估 在很大程度上取决于患者的躯体报告 症状学。 重要的是，要获得更好的 了解患者报告与 实际的潜在生理活动。 通常，自我报告 生理措施并不能很好地相关。 在 这一发现的可能原因是生理措施 已在实验室环境中而不是在患者的情况下进行 通常的日常活动。 卧床的建造 建议监视设备作为记录皮肤的一种手段 电导，心率，呼吸和活动水平 患者进行日常生活活动。 在过去的研究中，我们 发现尽管自我报告与 生理学很低，患者能够感知 压力下的生理活性变化。 在另一项研究中 我们发现高水平的自主唤醒患者 与低水平的患者的几个体细胞评级有所不同。 在 还有另一项研究，我们发现评级高的患者 自主症状学需要更高剂量的阿普唑仑 用于治疗比评级低的人。 在提议中 研究，我们希望确定是否高和低的患者 自主症状的水平在基础上有所不同 生理活动。 两组患者，一组 没有高水平的交感神经系统活动，将 通过卧床监测装置进行比较。 具体来说，有32名患者，还有32例不存在的患者 心pal和出汗的手掌将穿着卧床 监视设备进行8小时的记录。 他们将评价他们的 全天的症状和比较 在两组的生理记录和 在自我报告的症状和生理记录之间 在不同水平的感知压力下的两组。 数据 从研究中将使我们能够确定是否 报告不同的症状集不同 生理活动，以及躯体的自我报道是否 症状与实际的生理措施相关 患者的日常活动。