SOMATIC SYMPTOMS AND THE PSYCHOBIOLOGY OF ANXIETY

躯体症状和焦虑的心理生物学

• 批准号: 3381779
• 负责人: Rudolf Franz Walter Hoehn-Saric
• 金额: $ 6.1万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-03-01 至 1989-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3381779
• 关键词: anxiety; arousal; autonomic nervous system; benzodiazepines; dosage; heart disorder; human subject; mental disorder chemotherapy; patient monitoring device; psychophysiology; psychosomatic disorders; sign /symptom; stress; sweat

In anxiety disorders, the selection and assessment of treatment depend to a large extent on patient reports of somatic symptomatology. It is important, therefore to obtain a better understanding of the relationships between patient reports and actual underlying physiological activity. In general, self reports and physiological measures do not correlate very well. Among the possible reasons for this finding is that the physiological measures have been taken in laboratory settings rather than during patients' usual daily activities. The construction of an ambulatory monitoring device is proposed as a means of recording skin conductance, heart rate, respiration and activity levels while patients go about their daily life activities. In a past study we found that although correlations between self report and physiology are low, patients are able to perceive the direction of changes in physiologcial activity under stress. In another study we found that patients with high levels of autonomic arousal differ on several somatic ratings from patients with low levels. In still another study we have found that patients with high ratings of autonomic symptomatology require higher doses of alprazolam for treatment than do those with low ratings. In the proposed study, we wish to determine whether patients with high and low levels of autonomic symptomatology differ in underlying physiological activity. Two groups of patients, one with and one without high levels of sympathetic nervous system activity, will be compared by means of the ambulatory monitoring device. Specifically, 32 patients who do, and 32 who do not, present with heart palpitations and sweaty palms will wear the ambulatory monitoring device for 8 hours of recording. They will rate their symptoms throughout the day and comparisons will be made between the physiological recordings of the two groups and between the self reported symptoms and physiological recordings of two groups under different levels of perceived stress. Data from the study will allow us to determine whether patients who report different sets of symptoms differ in underlying physiological activity, and whether self reports of somatic symptoms correlate with actual physiologcial measures during patients' everyday activities.

在焦虑症中，治疗的选择和评估 很大程度上取决于患者对躯体症状的报告 症状学。 因此，获得更好的 了解患者报告与患者报告之间的关系 实际的潜在生理活动。 一般来说，自我报告 和生理测量的相关性不是很好。 其中 这一发现的可能原因是生理测量 是在实验室环境中而不是在患者治疗期间进行的 平常的日常活动。 流动站的建设 监测装置被提议作为记录皮肤的一种手段 电导、心率、呼吸和活动水平，同时 患者进行日常生活活动。 在过去的研究中我们 发现虽然自我报告与 生理机能较低，患者能够感知方向 压力下生理活动的变化。 在另一项研究中 我们发现自主神经唤醒水平较高的患者 与低水平患者的一些躯体评级不同。 在 另一项研究我们发现评分高的患者 自主神经症状需要更高剂量的阿普唑仑 比那些收视率低的人接受治疗。 在提议的 研究中，我们希望确定患者是否患有高和低 自主神经症状的水平在基础上有所不同 生理活动。 两组患者，一组患有，另一组患有 如果没有高水平的交感神经系统活动， 通过动态监测装置进行比较。 具体来说，32 名患者和 32 名患者没有出现以下症状： 心悸和手心出汗会佩戴动态 监控装置可进行8小时的录音。 他们会评价自己的 全天的症状并进行比较 两组的生理记录之间 自我报告的症状和生理记录之间 两组在不同程度的感知压力下的情况。 数据 这项研究将使我们能够确定患者是否 报告不同组的症状在根本上有所不同 生理活动，以及是否有躯体自我报告 症状与实际生理测量相关 患者的日常活动。