ETHICOBOTS 2 - One Health Research for Impact

ETHICOBOTS 2 - 一项具有影响力的健康研究

• 批准号: BB/S013806/1
• 负责人: James Wood
• 金额: $ 57.34万
• 依托单位: University of Cambridge
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2019
• 资助国家: 英国
• 起止时间: 2019 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FS013806%2F1
• 关键词: ETHICOBOTS; Health; Research; Impact

Ethiopia is the second most populous sub Saharan African country. It is also a predominantly agrarian country struggling to emerge from extreme poverty through an ambitious national growth and transformation plan, aiming to achieve middle income status by 2025. Livestock contributes to a high proportion of national income and is a pillars of economic development. Traditional extensive farming systems are being supplemented and replaced with intensive farming, in the case of dairy production using imported Holstein-Friesian crosses to meet high demand for dairy products in the rapidly growing urban population. Bovine tuberculosis (bTB) is endemic in Ethiopia and the prevalence is high in the emerging intensive dairy population, but currently low in local Zebu cattle. Periurban expansion of dairy farms has created hotspots of TB infection and there are no statutory controls in Ethiopia. Consequently, the potential for spread of bTB through trade is an emerging risk.Our ongoing ZELS research in Ethiopia, Ethiopian Control of Bovine Tuberculosis Strategies (ETHICOBOTS) aims to provide a scientific understanding for the development of sustainable control strategies for bTB in Ethiopia, to reduce the high rate of bTB and its zoonotic transfer in the expanding dairy sector, especially to more disadvantaged population sectors. This Supplementary proposal 'ETHICOBOTS 2 - One Health with Impact' focusses on ensuring maximal impact of the research undertaken to date. It will improve the scientific base established in ETHICOBOTS and will provide clear, evidence-based tools to tackle the high burden of bTB in different sectors of the dairy industry and any zoonotic transmission. We will deliver this work through three specific work-packages, addressing critical evidence gaps to maximise impact: - Develop a pathway for the Elimination of bovine TB infection from a sub-set of national herds, working closely with the Ministry of Agriculture and Livestock to clear Government farms of bTB. These farms will provide a clear local exemplar of how disease control based surveillance programmes can be successfully implemented. This will generate additional data on disease control and explore the prevalence of anergy, or test-insensitivity, in bovine TB infected cattle. - Explore new tools to communicate disease control to farmers. We will work with innovators in this field who have established new ways to communicate with farmers in other parts of Africa and in a collaboration with Farmerline, we will test their methods in Ethiopian dairies.- Address the major evidence gap regarding the cause of tuberculous disease in humans at high risk of exposure to infected cattle. Working with patients and health care facilities in areas with a high prevalence of bTB infection in cattle, we will markedly improve the diagnostic rate in TB patients by improving culture methods and by using modern molecular test to identify the causative disease agent (M. tuberculosis and M. bovis) in a range of samples, including testing for dual infections The results will provide practical and effective bTB control strategies, targeted at the disease and its zoonotic transmission to humans. Delivering impact through close collaboration with key government and industry stakeholders, we aim to prevent further geographic spread of the disease and to minimise the risks of further transmission to national zebu herd, to protect the livelihood of poor farmers. The project will be carried out with the active participation of the relevant government units and local communities in the field to maximize the likelihood of implementation of results into policy and practice.

埃塞俄比亚是撒哈拉以南非洲第二大的国家。这也是一个主要是农业国家，努力通过雄心勃勃的民族增长和转型计划从极端贫困中脱颖而出，旨在到2025年达到中等收入状况。牲畜贡献了很大的国民收入，并且是经济发展的支柱。在乳制品生产的情况下，使用进口的荷斯坦 - 弗里斯安（Holstein-Fiesian）十字架来满足迅速增长的城市人口中对乳制品的高需求。牛结核病（BTB）在埃塞俄比亚是地方性的，在新兴的密集乳制品人群中的患病率很高，但目前在当地的Zebu牛中很少。牛奶农场的城市扩张已经产生了结核病感染的热点，埃塞俄比亚没有法定控制。因此，BTB通过贸易传播的潜力是一种新兴的风险。埃塞俄比亚正在进行的ZELS研究，埃塞俄比亚对牛结核病策略的控制（Ethicobots）旨在为埃塞俄比亚BTB的可持续控制策略的发展提供科学的理解，以减少BTB的更多范围，以降低其Zoon的高度传播Dair的繁殖范围，并降低了DAIR的高度传统，该群体的传播范围扩展了，该策略是Zoon的高度传播。部门。这项补充提案“ Ethicobots 2-一种具有影响力的健康”的重点是确保迄今为止所进行的研究的最大影响。它将改善在乙科生物机构中建立的科学基础，并提供明确的，循证的工具，以应对乳制品行业不同部门和任何人畜共患传播的BTB的高负担。我们将通过三个特定的工作包进行这项工作，以解决关键证据差距以最大程度地影响影响： - 开发了从一组国民群中消除牛结核病感染的途径，与农业和牲畜部紧密合作以清除BTB的政府农场。这些农场将为如何成功实施基于疾病的监视计划提供一个清晰的当地典范。这将产生有关疾病控制的其他数据，并探索牛TB感染的牛的厌食或测试不敏感性的患病率。 - 探索将疾病控制与农民传达的新工具。我们将与该领域的创新者合作，他们建立了与非洲其他地区的农民进行交流的新方法，并与Farmerline合作，我们将在埃塞俄比亚乳制品中测试他们的方法。-解决了有关人类在人类造成的育成疾病的主要证据差距。 Working with patients and health care facilities in areas with a high prevalence of bTB infection in cattle, we will markedly improve the diagnostic rate in TB patients by improving culture methods and by using modern molecular test to identify the causative disease agent (M. tuberculosis and M. bovis) in a range of samples, including testing for dual infections The results will provide practical and effective bTB control strategies, targeted at the disease and its zoonotic transmission to人类。通过与主要政府和行业利益相关者的密切合作产生影响，我们旨在防止这种疾病的进一步地理传播，并最大程度地减少向国家Zebu群的进一步传播的风险，以保护贫穷农民的生计。该项目将随着该领域的相关政府部门和当地社区的积极参与而进行，以最大程度地将结果实施到政策和实践中。

项目成果

Population structure and transmission of Mycobacterium bovis in Ethiopia

埃塞俄比亚牛分枝杆菌的种群结构和传播

• DOI: 10.1101/2020.11.17.386748
• 发表时间: 2020
• 作者: Almaw G

Field evaluation of specific mycobacterial protein-based skin test for the differentiation of Mycobacterium bovis-infected and Bacillus Calmette Guerin-vaccinated crossbred cattle in Ethiopia.

• DOI: 10.1111/tbed.14252
• 发表时间: 2022-07
• 期刊: Transboundary and emerging diseases
• 影响因子: 4.3
• 作者: Bayissa B;Sirak A;Zewude A;Worku A;Gumi B;Berg S;Hewinson RG;Wood JLN;Jones GJ;ETHICOBOTS consortium;Vordermeier HM;Ameni G
• 通讯作者: Ameni G

Evaluation of the Efficacy of BCG in Protecting Against Contact Challenge With Bovine Tuberculosis in Holstein-Friesian and Zebu Crossbred Calves in Ethiopia.

• DOI: 10.3389/fvets.2021.702402
• 发表时间: 2021
• 期刊: Frontiers in veterinary science
• 影响因子: 3.2
• 作者: Bayissa B;Sirak A;Worku A;Zewude A;Zeleke Y;Chanyalew M;Gumi B;Berg S;Conlan A;Hewinson RG;ETHICOBOTS Consortium;Wood JLN;Vordermeier HM;Ameni G
• 通讯作者: Ameni G

The variable prevalence of bovine tuberculosis among dairy herds in Central Ethiopia provides opportunities for targeted intervention.

• DOI: 10.1371/journal.pone.0254091
• 发表时间: 2021
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Almaw G;Conlan AJK;Ameni G;Gumi B;Alemu A;Guta S;Gebre S;Olani A;Garoma A;Shegu D;Yimesgen L;Nigussie D;Wood JLN;Abebe T;Mihret A;Berg S;ETHICOBOTS consortium
• 通讯作者: ETHICOBOTS consortium

Population structure and transmission of Mycobacterium bovis in Ethiopia.

• DOI: 10.1099/mgen.0.000539
• 发表时间: 2021-05
• 期刊: Microbial genomics
• 影响因子: 3.9
• 作者: Almaw G;Mekonnen GA;Mihret A;Aseffa A;Taye H;Conlan AJK;Gumi B;Zewude A;Aliy A;Tamiru M;Olani A;Lakew M;Sombo M;Gebre S;Diguimbaye C;Hilty M;Fané A;Müller B;Hewinson RG;Ellis RJ;Nunez-Garcia J;Palkopoulou E;Abebe T;Ameni G;Parkhill J;Wood JLN;The Ethicobots Consortium;Berg S;van Tonder AJ
• 通讯作者: van Tonder AJ