A longitudinal model for the spread of bovine tuberculosis

牛结核病传播的纵向模型

基本信息

批准号：
BB/I012192/1
负责人：
James Wood
金额：
$ 37.48万
依托单位：
University of Cambridge
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2011
资助国家：
英国
起止时间：
2011 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=BB%2FI012192%2F1
关键词：
longitudinal model spread bovine tuberculosis

项目摘要

Bovine tuberculosis (bTB) is an important disease of cattle and badgers with substantial socio-economic impact in the UK, currently costing the exchequer over £100 million per year in surveillance and compensation and also resulting in costly movement and trade restrictions for farmers. Despite intensive controls, disease incidence is still increasing. Currently herds are monitored for the disease through slaughterhouse surveillance and through regular skin testing. The frequency of routine testing for an individual herd is based on localised incidence of the disease, which acts as a proxy for risk of infection, but does not account for individual herd-level characteristics or cattle movements. Recent bTB research has focussed on examining potential underlying causes for this, including environmental contamination (e.g. re-infection from local wildlife reservoirs), insensitivity to the surveillance test and the impact of large-scale cattle movements. It is the purpose of this proposal to extend our recent work identifying markers for the persistence of infection in individual herds into a dynamic longitudinal framework in order to quantify the mechanisms of transmission in the GB national herd and to test the utility of our results as an aid to risk-based surveillance. The dynamics of transmission of bTB infection can be represented by a model with transmission driven by chance processes, with an observation process that is governed by an imperfect test procedure (or slaughterhouse identification of visible lesions), leading to partially hidden infection. Herds that contain one or more reactors are classified as breakdowns, which then have movement restrictions and more rigorous testing imposed until the herd tests clear. Testing and cattle movement information is available through several large national datasets. Recent mathematical modelling approaches have been developed using these data and, while these will provide useful information on population-level parameters, they average out some detailed information available at the individual herd level. Also, they were not designed to predict disease recurrence at the individual-herd level. Here we propose to build a dynamic, statistical, individual-herd level model, based on continuous surveillance data, which we will fit to the data using a likelihood-based approach. The main methodological challenge will be to deal with the hidden states (infection) and the movement of animals between the herds. Recent advances in statistical methodology, such as 'data-augmented' and 'reversible-jump' Markov chain Monte Carlo allow the joint distribution of the observed and hidden states to be estimated simultaneously along with key infection related parameters. We will explore an exciting alternative called 'sequential filtering'. The main challenge is that these statistical techniques are computationally intensive, especially given the large scale (approx. 130,000 premises) and long time frame (6+ years) of the datasets. However, advances in computer processing technology, such as architectures for running algorithms in parallel on graphics cards, provide an exciting and cost-effective way to approach this problem. The focus here is on bTB, but these sorts of models and the estimation issues that we will address are relevant to a wide range of infectious disease systems, and the methodology developed in this project would be applicable to a range of disease systems. It is the aim of this project to elicit information about the hidden states of the system from the test observations using robust statistical methodology, in a way that allows us to identify high-risk herds based on the past history of infection, as well as on localised incidence and connectedness to other premises. This information would have a practical use in terms of targeting specific herds with more stringent or more regular testing.

牛结核病（BTB）是一个重要的，并且在英国具有重大的社会经济影响，目前使超过1亿英镑的生态化，也导致了昂贵的运动和贸易限制。疾病的疾病调查常规的皮肤测试。例如，重新感染），大型牛运动中的无敏度和大规模运动的影响。我们的结果是基于风险的监视。 KDowns，Jave运动的限制和严格的测试是通过几个大型国家数据集使用的。牛群在个人遗体水平上预测疾病的复发。处理隐藏状态（感染）和牛群之间的动物运动。。对于运行算法的厌恶卡，为解决此问题的重点提供了一种令人兴奋且具有成本效益的方式。一系列疾病系统。根据过去的感染史以及对其他前提的局部性分裂性，使用稳健的统计方法进行测试。进行更潮流或更常规的测试。

项目成果

期刊论文数量（9）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Eliminating bovine tuberculosis in cattle and badgers: insight from a dynamic model.

DOI：
10.1098/rspb.2015.0374
发表时间：
2015-06-07
期刊：
Proceedings. Biological sciences
影响因子：
0
作者：
Brooks-Pollock E;Wood JL
通讯作者：
Wood JL

Age-dependent patterns of bovine tuberculosis in cattle.

DOI：
10.1186/1297-9716-44-97
发表时间：
2013-10-16
期刊：
Veterinary research
影响因子：
4.4
作者：
Brooks-Pollock E;Conlan AJ;Mitchell AP;Blackwell R;McKinley TJ;Wood JL
通讯作者：
Wood JL

Estimation of the relative sensitivity of the comparative tuberculin skin test in tuberculous cattle herds subjected to depopulation.

DOI：
10.1371/journal.pone.0043217
发表时间：
2012
期刊：
PloS one
影响因子：
3.7
作者：
Karolemeas K;de la Rua-Domenech R;Cooper R;Goodchild AV;Clifton-Hadley RS;Conlan AJ;Mitchell AP;Hewinson RG;Donnelly CA;Wood JL;McKinley TJ
通讯作者：
McKinley TJ

Additional file 2: of Universal test, treat, and keep: improving ART retention is key in cost-effective HIV control in Uganda

附加文件 2：普遍检测、治疗和保存：提高 ART 保留率是乌干达经济有效的艾滋病毒控制的关键