FUNCTIONAL ORGANIZATION AND CONTROL OF HUMAN MASSETERS

人类咬肌的功能组织和控制

• 批准号: 3223750
• 负责人: CHARLES G. WIDMER
• 金额: $ 13.21万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-08-01 至 1996-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3223750
• 关键词: afferent nerve; bite strength; dissection; electrodes; electromyography; electronic stimulator; gingiva; human tissue; injection /infusion; jaw movement; lip; magnetic resonance imaging; mastication; muscle; muscle contraction; neuroanatomy; neuromuscular function; neuromuscular system; oral facial pain; palate; saline; stretch reflex; trigeminal nerve

Animal studies have provided a detailed analysis of muscle fiber types, muscle organization, neuroanatomical pathways and mechanisms of neural control of jaw muscles during such acts as mastication. The data from these studies have helped form the current explanations of the neurobiology and control of oral-motor function. However, recent data have provided evidence of a more complex anatomical and functional organization of the jaw muscles in animals but similar systematic studies have not been performed in human subjects. With the advent of new technologies, it is now possible to non-invasively image muscles to examine the detail of the anatomical organization and to simultaneously acquire multi-site recordings to analyze regional muscle activity or functional "compartments". It is imperative to understand the fundamentals of anatomical organization and functional control of normal human subjects before attempting to evaluate the abnormal muscular conditions which involve pain. Therefore, this proposal will examine the basic fundamentals of the anatomical substrate, functional organization and mechanisms of control of the human masseter muscle. A logical progression will be followed by first examining the masseter internal anatomical architecture to identify its structural partitions in cadavers and magnetic resonance images of humans, and then studying the functional neuromuscular compartments of the muscle by multi-site EMG recordings. This latter group of experiments include (1) mapping motor unit territory, recruitment order and motor unit characteristics; (2) investigating the effects of afferents on the recruitment and activity of motor units; and (3) comparing the inhibitory effects of cutaneous afferents from several intraoral sites on motor unit activity. After a thorough evaluation of the functional organization of the masseter muscle in normal subjects without pain, we will examine the same subjects with experimentally-induced facial pain and test a model that attempts to explain the changes in motor activity described in chronic pain patients.

动物研究提供了肌肉纤维的详细分析 类型，肌肉组织，神经解剖途径和机制 在咀嚼之类的作用过程中，下颌肌肉的神经控制。 数据 从这些研究中有助于形成当前的解释 神经生物学和口腔运动功能的控制。 但是，最近的数据 已经提供了更复杂的解剖学和功能的证据 组织中下颌肌肉的组织，但类似的系统研究 尚未在人类受试者中进行。 随着新的到来 技术，现在可以非侵入地将肌肉形象化为 检查解剖组织的细节并同时检查 获取多站点记录以分析区域肌肉活动或 功能“隔室”。 必须了解 解剖组织的基础和正常功能控制 试图评估异常肌肉之前的人类受试者 涉及疼痛的情况。 因此，该提案将研究 解剖基板，功能组织和机制 控制人kseter肌肉。 逻辑进展将是 其次是首先检查摩斯特内部解剖结构 识别其在尸体和磁共振中的结构分区 人类的图像，然后研究功能性神经肌肉 通过多站点EMG记录的肌肉隔室。 后者 一组实验包括（1）映射电动机单位区域， 招聘顺序和运动单位特征； （2）调查 传入对运动单位募集和活动的影响；和 （3）比较几种皮肤传感的抑制作用 运动单位活动的口腔内部位。 经过彻底评估 正常受试者中咬肌的功能组织 没有痛苦，我们将与 实验引起的面部疼痛和测试试图尝试的模型 解释慢性疼痛患者描述的运动活动的变化。