FUNCTIONAL ORGANIZATION AND CONTROL OF HUMAN MASSETERS

人类咬肌的功能组织和控制

• 批准号: 3072244
• 负责人: CHARLES G. WIDMER
• 金额: $ 6.99万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-08-01 至 1996-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3072244
• 关键词: afferent nerve; bite strength; dissection; electrodes; electromyography; electronic stimulator; gingiva; human tissue; injection /infusion; jaw movement; lip; magnetic resonance imaging; mastication; morphology; muscle; muscle contraction; neuromuscular function; neuromuscular system; oral facial pain; palate; saline; stretch reflex; trigeminal nerve

Long term career objectives of mine consist of (1) maintaining a productive and meaningful research program in the area of masticatory motor control; (2) having a positive impact on the teaching of students by utilizing a multi-disciplinary approach (basic and clinical sciences); and (3) providing the most effective evaluation and treatment services to patients based on our current knowledge. With a firm foundation in both the basic sciences and clinical fields, the ability to develop meaningful hypotheses and test them appropriately on a scientific basis may be enhanced. My immediate career objective, therefore, is to refine and extend my basic knowledge in the field of neurophysiology, and more specifically, in the area of motor control mechanisms. The RCDA would provide a mechanism for: (1) developing the fundamental background; (2) learning laboratory techniques for animal investigations; (3) learning mammalian motor control mechanisms in the limb by direct participation in on-going NIH funded research in three laboratories as well as a sabbatical outside the University; and ) increasing the interdisciplinary exchange of ideas in the basic and clinical sciences with the ultimate objective of applying this broader base of knowledge towards investigating health-related problems. An integration of the expertise from the University of Florida (Dr. John Munson) and Emory University (Dr. A.W. English and Dr. T.R. Nichols) will provide a substantial experience in the area of motor control following nerve regeneration, developmental aspects of neuromuscular compartments, and the regulation of posture and stiffness and their relationship to muscle length and force changes, cutaneous inputs and brainstem structures. In addition, spending a six month sabbatical near the end of the RCDA period at another institution would further broaden my background. I would consider laboratories which have a major research focus on the masticatory system. The research to be conducted in parallel to the informal training will examine the basic fundamentals of the anatomical substrate, functional organization and mechanisms of control of the human masseter muscle (similar to the studies of Dr. A.W. English in cat hindlimb). A logical progression will be followed by first examining the masseter internal anatomical architecture to identify its structural partitions, and then study the functional neuromuscular compartments of the muscle by multi-site EMG recordings. After a thorough evaluation of the functional organization of the masseter muscle in normal subjects without pain, we will examine asymptomatic subjects with experimentally-induced facial pain.

我的长期职业目标包括（1）维护 咀嚼性领域的富有意义的研究计划 电动机控制； （2）对学生的教学产生积极影响 利用多学科方法（基础和临床科学）；和 （3）提供最有效的评估和治疗服务 基于我们当前的知识的患者。 两者都坚定地基础 基本科学和临床领域，发展有意义的能力 假设并在科学的基础上适当地测试它们 增强。 因此，我的直接职业目标是完善和 扩展我在神经生理学领域的基本知识等等 具体而言，在运动控制机制的领域。 RCDA会 提供以下机制：（1）发展基本背景； （2） 学习动物调查的实验室技术； （3）学习 通过直接参与肢体中的哺乳动物运动控制机制 正在进行的NIH资助了三个实验室的研究以及休假 大学外； ）增加了跨学科交流 基础科学和临床科学的想法，其最终目标 将这种更广泛的知识基础用于调查 与健康有关的问题。 从 佛罗里达大学（约翰·芒森博士）和埃默里大学（A.W.博士 英语和T.R.博士尼科尔斯）将在 神经再生，发育方面的运动控制区域 神经肌区室，以及姿势和刚度的调节 以及它们与肌肉长度和力变化的关系，皮肤输入 和脑干结构。 此外，花了六个月的休假 在RCDA时期结束时，另一家机构将进一步 扩大我的背景。 我会考虑具有专业的实验室 研究重点是咀嚼系统。 该研究要进行 与非正式培训平行于非正式培训将检查 解剖基材，功能组织和控制机制 人类的肌肉肌肉（类似于A.W.英语博士的研究 在猫后肢）。 逻辑进展将紧随其后 检查摩斯特内部解剖结构以识别其 结构分区，然后研究功能性神经肌肉 通过多站点EMG记录的肌肉隔室。 彻底后 评估正常咬肌的功能组织 没有疼痛的受试者，我们将检查无症状的受试者 实验引起的面部疼痛。