Ultrasensitive electrochemical biosensors

超灵敏电化学生物传感器

• 批准号: LP170100230
• 负责人: Prof Kirill Alexandrov
• 金额: --
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Linkage Projects
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2018-01-01
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LP170100230
• 关键词: Ultrasensitive; electrochemical; biosensors

This project aims to develop novel proteins that can convert biochemical cues into electronic signals. Using protein engineering, this project will produce redox protein-based OFF switches. The project expects that the use of the OFF-switches (as opposed to ON switches) will simplify biosensor design and create a new class of sensory architectures. Integration of OFF-switch-based biosensors with an enzymatic signal amplification circuit is expected to yield ultrasensitive sensory systems with near-real-time response. The project will address a need for new technologies that enable collection of physiological and environmental information rapidly, and at low cost outside of the specialised laboratories.

该项目旨在开发能够将生化线索转化为电子信号的新型蛋白质。该项目将利用蛋白质工程生产基于氧化还原蛋白质的关闭开关。该项目预计使用关闭开关（相对于开启开关）将简化生物传感器设计并创建新型传感架构。基于关闭开关的生物传感器与酶信号放大电路的集成有望产生具有近实时响应的超灵敏传感系统。该项目将满足对新技术的需求，这些新技术能够在专业实验室之外以低成本快速收集生理和环境信息。