Development of a novel high yield cell-free protein expression system

新型高产无细胞蛋白表达系统的开发

• 批准号: LP100100394
• 负责人: Prof Kirill Alexandrov
• 金额: $ 30.3万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Linkage Projects
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-09-15 至 2013-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LP100100394
• 关键词: Development; novel; yield; cell; free

Recombinant proteins are used as vaccines, drugs, and research tools, as well as food and detergent additives, comprising a A$100 billion international market. Their production requires laborious, expensive, and time-consuming construction of transgenic organisms or cells. Alternatively, recombinant proteins can be produced in extracts prepared from cells or organisms. The aim of this proposal is to develop a new technology that will make cell-free production of recombinant proteins rapid, cheap, and scalable. This will advance Australia’s intellectual leadership in the area of biotechnology and will bring numerous economic benefits by accelerating pharmaceutical development.

重组蛋白被用作疫苗、药物和研究工具，以及食品和洗涤剂添加剂，其国际市场价值达 1000 亿澳元，其生产需要费力、昂贵且耗时的转基因生物体或细胞的构建。该提案的目的是开发一种新技术，使重组蛋白的无细胞生产变得快速、廉价且可扩展，这将提高澳大利亚的智力领先地位。在生物技术领域，将通过加速药品开发带来巨大的经济效益。