Using chemistry to illuminate sulfoglycolysis, a major organosulfur pathway

利用化学阐明磺基糖酵解（一种主要的有机硫途径）

• 批准号: DP180101957
• 负责人: Prof Spencer Williams
• 金额: $ 34.78万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-07-01 至 2021-06-30
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP180101957
• 关键词: Using; chemistry; illuminate; sulfoglycolysis; major

This project aims to develop a detailed molecular description of the sulfoglycolysis pathway, a major pathway involved in cycling an abundant sulfolipid. The project will use an integrated chemical, biochemical and structural approach to illuminate how sulfoglycolysis degrades sulfolipid to access its elemental and energy constituents. Expected outcomes include an advanced understanding of the biosulfur cycle, the development of new chemical approaches to manipulate sulfur cycling for agricultural and biotechnology applications, and deepened ties to leading international researchers. Potential benefits include new strategies to reduce dependence on agricultural fertilisers, promote gut wellbeing, and control insect pests.

该项目旨在对磺基糖酵解途径进行详细的分子描述，磺基糖酵解途径是参与丰富硫脂循环的主要途径。该项目将采用综合化学、生物化学和结构方法来阐明磺基糖酵解如何降解硫脂以获取其元素和能量成分。预期成果包括对生物硫循环的深入了解，开发用于农业和生物技术应用的操纵硫循环的新化学方法，以及加深与国际领先研究人员的联系。潜在的好处包括减少对农业肥料依赖、促进肠道健康和控制害虫的新策略。