Mannosyl transfer processes in leishmania and mycobacteria

利什曼原虫和分枝杆菌中的甘露糖基转移过程

• 批准号: DP1093356
• 负责人: Prof Spencer Williams
• 金额: $ 22.99万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-04-01 至 2013-06-30
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP1093356
• 关键词: Mannosyl; transfer; processes; leishmania; mycobacteria

The human diseases leishmaniasis and tuberculosis are caused by infectious microorganisms. We will target pathways to the biosynthesis and degradation of parasite-specific mannose containing metabolites that play essential roles in the ability of these pathogens to cause disease. We will develop new ways to study these pathways, and will synthesize novel substrates and inhibitors that will allow the development of antituberculosis and antileishmanial drugs. This project will contribute to our national competitiveness in the newly emerging area of chemical biology.

人类疾病利什曼病和结核病是由传染性微生物引起的。我们将针对寄生虫特异性甘露糖的生物合成和降解的途径，这些甘露糖含有代谢物，这些代谢物在这些病原体引起疾病的能力中起着至关重要的作用。我们将开发研究这些途径的新方法，并将综合新型底物和抑制剂，从而允许抗结核和抗精神病药的发展。该项目将有助于我们在新兴化学生物学领域的全国竞争力。