Fluorescence tools that illuminate biology and inspire translation

阐明生物学并激发翻译的荧光工具

• 批准号: 10372854
• 负责人: Alanna Schepartz
• 金额: $ 12.73万
• 依托单位: UNIVERSITY OF CALIFORNIA BERKELEY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-02-01 至 2025-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10372854
• 关键词: Area; Binding; Biology; Cells; Chemistry; Complex; Development; Disease; Elements; Fluorescence; Fluorescence Spectroscopy; Functional disorder; Goals; Health; Human; Influentials; Laboratories; Molecular Analysis; Molecular Structure; National Institute of General Medical Sciences; Organelles; Property; Proteins; Research; Translations; design; innovation; multidisciplinary; novel; programs; tool

A. Summary (1R35GM134963). Understanding the mechanisms of protein and organelle function and dysfunction requires dynamic analysis of molecular structures and interactions in live cells. A long-term goal of my laboratory is to develop tools that reveal these functional elements and apply them to discover novel an significant biology and molecules with useful or influential properties. I am drawn to complex, multi-disciplinary problems where chemistry catalyzes exciting and non-incremental progress. We strive not simply to develop tools but also apply them in innovative ways. Fluorescence spectroscopy features prominently in the two research programs described herein. In both, fluorescent tools that we developed using prior NIGMS support have uncovered influential new biology; this application continues this development and expands the new biology to benefit human health.

A.摘要（1R35GM134963）。了解蛋白质和细胞器的机制 功能和功能障碍需要动态分析分子结构和相互作用 在活细胞中。我实验室的长期目标是开发揭示这些功能的工具 元素并应用它们以发现新颖的生物学和有用的分子 或有影响力的特性。我被化学的复杂，多学科问题所吸引 催化令人兴奋和非进步的进展。我们不仅努力开发工具，而且还在 也以创新的方式应用它们。荧光光谱特征在 本文描述的两个研究计划。在这两种情况下，我们都使用的荧光工具 事先的纽约支持已经揭示了有影响力的新生物学；此应用程序继续 开发并扩大新的生物学以使人类健康受益。