CHRONIC ALCOHOLISM AND MALE SEXUAL DSYFUNCTION

慢性酗酒与男性性功能障碍

• 批准号: 3112225
• 负责人: RAUL C SCHIAVI
• 金额: $ 33.07万
• 依托单位: MOUNT SINAI SCHOOL OF MEDICINE OF CUNY
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-04-01 至 1993-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3112225
• 关键词: alcoholism /alcohol abuse; blood chemistry; case history; chronic disease /disorder; electroencephalography; estrogens; human subject; impotence; luteinizing hormone; male reproductive system disorder; male reproductive system disorder diagnosis; marriage /marital status; penis; pituitary gonadal axis; prolactin; psychosomatic disorders; sex behavior; sex behavior disorder; sleep; testosterone

Sexual disorders have been frequently reported in chronic alcoholic men but effective treatment and preventive measures have been limited by the paucity of empirical information on the nature, prevalence and pathogenesis of their sexual difficulties. This proposal is to assess within a cross- sectional and controlled framework the organic, psychological and relationship parameters and to investigate the interactive effect of these variables in the sexual functioning of a well-defined population of alcoholic men. Specifically, the central aims of the research are: (1) to describe the sexual functioning of a sample of abstinent chronic alcoholic men living with a female partner for at lease one year, (2) to evaluate sleep parameters and degree of erectile capacity by means of nocturnal penile tumescent (NPT) recordings and to investigate the relation between NPT and sexual functioning, (3) to assess pituitary gonadal hormones during sleep and to explore the relation between the endocrine variables and sexual functioning, (4) to assess systematically psychological and marital factors in relation to sexual functioning, and (5) to explore the interaction between psychological, relationship dimensions and physiological measures on the extent of sexual dysfunction. A sample of 105 chronic alcoholic men who are abstinent and free from coexisting medical illnesses or medications, between the ages of 25 to 60, will be selected for study. They will be compared to 40 healthy non-alcoholic controls who are free from sexual dysfunctions and who meet similar inclusion/exclusion criteria. During the initial phase several sessions will be devoted to screening each couple, assessing the alcoholic history, psychosexual behavior and psychopathology, conducting a medical evaluation and blood chemistries and administering a battery of psychological instruments. In the second phase, subjects will be scheduled for four nights in the sleep laboratory for the recording of EEG, NPT and the sequential determination of testosterone, bound and free, LH, prolactin and estrogen during sleep. The relation between biomedical and psychological variables and sexual functioning will be explored by analysis of variance, analysis of covariance, correlation analysis and multiple regression techniques. Conceptually, this study will be based on a multi-disciplinary framework which will incorporate valid psychological measures and objective biomedical procedures and techniques. It will generate information of value for predictive studies as well as for the development of effective diagnostic and therapeutic approaches for sexually dysfunctional alcoholic patients.

慢性酗酒男人经常报告性疾病 有效的治疗和预防措施受到了 关于性质，患病率和发病机理的经验信息的匮乏 他们的性困难。 该提议是在跨境中评估 部分和受控框架有机，心理和 关系参数并研究这些参数 定义良好的人口的性功能中的变量 酗酒的人。 具体而言，研究的核心目的是：（1） 描述禁忌慢性酒精样本的性功能 男性与女性伴侣一起租赁一年，（2）评估 夜间的睡眠参数和勃起能力的程度 阴茎肿瘤（NPT）记录并研究 NPT和性功能，（3）评估垂体性腺激素 睡眠并探索内分泌变量与 性功能，（4）系统地评估系统心理和婚姻 与性功能有关的因素，以及（5）探索 心理，关系维度与 关于性功能障碍程度的生理措施。 样本 105个戒酒且没有共存的慢性酒鬼男性 25至60岁之间的医疗疾病或药物将是 选择学习。 他们将与40个健康的非酒精饮料进行比较 没有性功能障碍并遇到类似性功能的对照 包含/排除标准。 在初始阶段几次会议 将致力于筛查每对夫妇，评估酒精历史， 心理行为和心理病理学，进行医学评估 和血液化学和管理一系列心理 乐器。 在第二阶段，受试者将安排为四个 在睡眠实验室的夜晚记录脑电图，不应该月室和 顺序测定睾丸激素，结合和游离，LH，催乳素和 睡眠期间的雌激素。 生物医学和心理变量与性之间的关系 将通过方差分析来探索功能，分析 协方差，相关分析和多重回归技术。 从概念上讲，这项研究将基于多学科框架 这将结合有效的心理措施和目标 生物医学程序和技术。 它将生成信息 预测研究的价值以及有效的发展 性功能失调酒精的诊断和治疗方法 患者。