THE ROLE OF OPERANT CONTINGENCIES AND ENVIRONMENTAL STRESSORS IN AN ANIMAL MODEL

操作性意外事件和环境压力因素在动物模型中的作用

• 批准号: 8167630
• 负责人: Christopher Bloom
• 金额: $ 4.76万
• 依托单位: UNIVERSITY OF RHODE ISLAND
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8167630
• 关键词: Address; Animal Model; Anxiety; Arousal; Autistic Disorder; Behavior; Clinical; Computer Retrieval of Information on Scientific Projects Database; Emotions; Environment; Fright; Funding; Genetic; Goals; Grant; Institution; Light; Mental disorders; Population; Prevalence; Process; Research; Research Personnel; Research Project Grants; Resources; Role; Source; Stress; Suicide; Syndrome; Time; Tissues; United States National Institutes of Health; Work; animal model development; cost; emotion regulation; environmental stressor; non-suicidal self injury

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The term non-suicidal self-injury (NSSI) has been applied to a wide range of behaviors that result in the damage of one's own body tissue in the absence of intent to die. Populations comprised of those suffering from genetic syndromes, such as Prader-Willi, and psychological disorders such as autism and normative populations have all demonstrated NSSI. The seriousness and prevalence of these behaviors has led to a great deal of research both basic and clinical, investigating these populations. Much of that recent work has focused on the role of NSSI in emotion regulation. Specifically, it has been proposed that NSSI allow for a decrease or escape from aversive arousal associated with negative emotions such as fear or anxiety. This proposal outlines the development of an animal model of NSSI to shed light on the role of environmental stress and operant processes such as escape and avoidance in maintaining NSSI. The goal of this proposed research project is to develop an animal model of NSSI. In doing so, these specific goals will be addressed: (1) Determine if a fear evoking environment results in an increase in NSSI; (2) Determine if any increase in NSSI comes at the cost of a decrease in an effective and healthy behavior; (3) Determine which factors, such as the timing, regularity and predictability, of the environmental stressor, are most predictive of NSSI.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 非自杀性自伤（NSSI）一词已广泛应用于在没有死亡意图的情况下导致自身身体组织受损的行为。患有普瑞德威利等遗传综合症、自闭症等心理障碍的人群以及正常人群都表现出 NSSI。 这些行为的严重性和普遍性引发了大量基础和临床研究，调查这些人群。最近的大部分工作都集中在 NSSI 在情绪调节中的作用。具体来说，有人提出 NSSI 可以减少或逃避与恐惧或焦虑等负面情绪相关的厌恶性唤起。该提案概述了 NSSI 动物模型的开发，以阐明环境压力和逃避和回避等操作过程在维持 NSSI 中的作用。 该研究项目的目标是开发 NSSI 动物模型。在此过程中，将实现以下具体目标： (1) 确定引发恐惧的环境是否会导致 NSSI 增加； (2) 确定 NSSI 的增加是否会以有效和健康行为的减少为代价； (3) 确定环境应激源的时间、规律性和可预测性等哪些因素最能预测 NSSI。