PSYCHOPHYSIOLOGY OF SEXUAL FUNCTION AND DYSFUNCTION

性功能和功能障碍的心理生理学

• 批准号: 3117990
• 负责人: RAUL C SCHIAVI
• 金额: $ 21.15万
• 依托单位: MOUNT SINAI SCHOOL OF MEDICINE OF CUNY
• 依托单位国家: 美国
• 财政年份: 1986
• 资助国家: 美国
• 起止时间: 1986-12-01 至 1995-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3117990
• 关键词: aging; arousal; blood chemistry; dosage; emotions; hormone regulation /control mechanism; hormone therapy; human middle age (35-64); human old age (65+); human subject; human therapy evaluation; interview; libido; male; penis erection; pituitary gonadal axis; placebos; psychobiology; psychological tests; psychopharmacology; psychophysiology; sex behavior; sex behavior disorder; sleep; testosterone

The overall decrease in sexual activity and pituitary-gonadal function observed with aging has led to the hypothesis that androgen deficiency is responsible for the decline in sexual behavior. Although testosterone is used in the treatment of sexual dysfunctions, there is a dearth of controlled, methodologically adequate studies on physically healthy individuals. The objective of this study is to investigate the behavioral and psychophysiologic effects of androgen administration on men aged 45 to 74 with inhibited sexual arousal or hypoactive sexual desire. Specifically, the central aims are to assess the effect of exogenous testosterone on (1) circulating hormone levels, (2) sexual behavior, affect and mood, (3) sleep and nocturnal penile tumescent (NPT) variables, and (4) erectile and subjective responses to controlled presentation of erotic stimuli. Sixty physically healthy men will receive testosterone enanthate at two dose levels in a double-blind, placebo controlled cross-over study design. During the initial phase, several sessions will be devoted to screening each couple, assessing psychosexual behavior, conducting a medical evaluation and blood chemistries, administering a battery of psychological instruments and recording erectile responses during sleep and in response to visual stimuli. The initial assessment will be followed by 18 weeks of treatment divided into three periods of six weeks in which the subject will receive each of the androgen doses and the placebo. Drug free intervals of four weeks will separate the drug and placebo periods. Interview rating will be conducted at weekly intervals at which time blood samples will be obtained for assessment of hormonal status. The administration of a battery of psychological instruments and recording of sleep/NPT and erectile responses to visual stimuli will be repeated at the completion of drug/placebo study periods. The effect of androgen administration on endocrine, psychologic, psychophysiologic and behavioral variables and the influence of age on these responses will be explored by a multifactor analysis of variance, correlation analysis and multiple regression techniques. Conceptually, this study based on a multidisciplinary framework may contribute to the understanding of the role of androgens on sexual function. At a practical level, it may generate important information on the efficacy of testosterone for the treatment of sexual dysfunctions in older men.

性活动和垂体贡献功能的总体下降 通过衰老观察到了雄激素缺乏症的假设 负责性行为下降。 虽然睾丸激素是 用于治疗性功能障碍时，缺乏 对身体健康的控制，理性地进行了足够的研究 个人。 这项研究的目的是研究行为 雄激素给药对45岁男性的心理生理影响 74具有抑制性唤醒或性行为的性欲。 具体而言，中心目的是评估外源性的影响 （1）循环激素水平的睾丸激素，（2）性行为，影响 和情绪，（3）睡眠和夜间阴茎肿胀（NPT）变量，（4） 勃起和主观的对色情表现的反应 刺激。 六十名身体健康的男性将获得睾丸激素 在双盲，安慰剂控制的交叉研究中，以两个剂量水平为 设计。 在初始阶段，几个会议将用于 筛选每对夫妇，评估心理行为，进行 医学评估和血液化学，管理一电池 心理仪器和记录在睡眠期间的勃起反应 响应视觉刺激。 初步评估将随后 18周的治疗分为六个星期的三个周期 受试者将接受每种雄激素剂量和安慰剂。 无药物 四个星期的间隔将分开药物和安慰剂期。 面试评级将以每周的间隔进行血液进行 将获得样品以评估激素状态。 这 管理一系列心理仪器和记录 睡眠/ntt和对视觉刺激的勃起反应将在 药物/安慰剂研究期的完成。 雄激素给药对内分泌，心理学， 心理生理和行为变量以及年龄对 这些响应将通过多因素方差分析来探索， 相关分析和多重回归技术。 从概念上， 这项基于多学科框架的研究可能有助于 了解雄激素对性功能的作用。 在实用 级别，它可能会生成有关功效的重要信息 睾丸激素治疗老年男性性功能障碍。