EYE MOVEMENT--FORCE, MOTION, AND ANATOMY RELATIONSHIPS

眼睛运动——力、运动和解剖关系

• 批准号: 2838358
• 负责人: STEPHEN J GOLDBERG
• 金额: $ 14.05万
• 依托单位: VIRGINIA COMMONWEALTH UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-12-06 至 2000-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2838358
• 关键词: Primates; electromyography; extraocular muscle; eye movements; magnetic field; motor neurons; muscle function; muscle strength; muscle stress; muscle tension; neuroanatomy; neuromuscular function; neuroregulation; psychomotor function; single cell analysis; visual fixation

DESCRIPTION (Investigator's abstract): The neural control of movement has long been a topic of critical scientific and clinical concern. Study of spinal cord motor systems has historically attracted the most attention and the majority of our theories of motor control have come from that research. Three specific experiments, derived from the clinical and research issues developed from these earlier studies, have been designed to examine the precisely regulated eye movement motor control system of the primate. The first experiment, using the lateral rectus muscle set at isometric tension, will examine: a) the functional range and types of extraocular motor units; b) motor unit recruitment by determining the response threshold of motoneurons to stimulation of an excitatory monosynaptic input; c) the relationship between stimulation frequency and tetanic tension (kt value) versus the relationship between motoneuron firing frequency and fixated eye position (K value) in order to further explore recruitment order; d) muscle unit force using stimulation parameters based on actual motoneuron firing patterns; e) compartmentalization or organization of muscle units using separate electromyogram electrodes placed in the orbital and the global layers of the lateral rectus muscle. The second experiment will be the first to examine the contribution of a single motor unit to an identified movement using the magnetic search coil technique coupled with muscle unit tension recordings. This study will be identical to the first in terms of neuronal stimulation parameters, but the lateral rectus muscle will remain attached to the globe and the animal will be placed in a magnetic coil system to measure the eye movement excursions and fixations elicited by stimulation of a single motoneuron. Last, compartmentalization of the abducens nerve and lateral rectus muscle will be examined since such organizational patterns often suggest movement or task oriented behavior within areas of a single muscle. These data will provide the first direct insight into the contributions of individual motor units to specific movements and could furnish the basis for models of movement control. Since surgical and pharmacological interventions at the muscle and muscle tendon are used to correct extraocular disorders, these studies may provide a new dimension to our clinical armamentarium at the level of the nerve and muscle.

描述（研究者的摘要）：运动的神经控制 长期以来一直是一个关键的科学和临床关注的话题。研究 脊髓运动系统历史上吸引了最大的关注 我们的大多数运动控制理论都来自于此 研究。三个特定的实验，源自临床和 这些早期研究已设计的研究问题已被设计 检查精确调节的眼动运动控制系统 灵长类动物。第一个实验，使用侧直肌肌组 在等距张力下，将检查：a）功能范围和类型 眼外运动单元； b）通过确定 运动神经元对刺激的响应阈值 单突触输入； c）刺激频率之间的关系 和甲烷张力（KT值）与 Motoneuron发射频率和固定的眼睛位置（K值） 进一步探索招聘令； d）使用肌肉单位力 基于实际运动神经元射击模式的刺激参数； e） 使用单独的肌肉单位分隔或组织 放置在轨道和全局层的肌电图电极 外侧直肌肌肉。第二个实验将是第一个 检查单个电机单元对确定运动的贡献 使用磁搜索线圈技术与肌肉单位张力相结合 录音。 这项研究将与第一项相同 神经元刺激参数，但外侧直肌肌肉将 保持固定在地球上，将动物放在磁性 线圈系统测量引起的眼睛运动偏移和固定系统 通过刺激单个运动神经元。最后，分隔 将检查神经和外侧肌肉肌肉的外侧肌肉 组织模式通常暗示运动或以任务为导向的行为 在单个肌肉的区域内。 这些数据将提供第一个 直接洞悉单个电机单元对 特定运动，可以为运动模型提供基础 控制。由于肌肉的手术和药理干预措施 和肌肉肌腱用于纠正眼外疾病，这些 研究可能为我们的临床武术提供了新的维度 神经和肌肉的水平。