Psychophysiology of Emotion in Alzheimer's Disease

阿尔茨海默病情绪的心理生理学

• 批准号: 6622844
• 负责人: ALFRED W. KASZNIAK
• 金额: $ 7.58万
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-05-08 至 2004-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6622844
• 关键词: Alzheimer's disease; arousal; behavioral /social science research tag; clinical research; communication behavior; cues; electromyography; emotions; extraocular muscle; face expression; galvanic skin response; human subject; patient oriented research; psychophysiology; startle reaction; stimulus /response; Alzheimer's disease; arousal; behavioral /social science research tag; clinical research; communication behavior; cues; electromyography; emotions; extraocular muscle; face expression; galvanic skin response; human subject; patient oriented research; psychophysiology; startle reaction; stimulus /response

The long-term goal of this research is to assess emotion processing abilities of individuals with Dementia of the Alzheimer Type (DAT). While much is now known about the cognitive deficits associated with DAT, relatively little is known about how the disease process might affect emotion-related experiences and behaviors. Many have observed that persons with DAT display changes in emotionality, including suspiciousness, agitation, and irritability, and these changes contribute in part to significant caregiver distress. However, several clinicians have made recommendations regarding how best to communicate with persons with DAT after language abilities with deteriorated, and these recommendations have including enlisting the use of emotion expression, which is assumed to remain relatively intact. There exists insufficient evidence to support the notion that emotion cue processing is preserved in DAT. What work has been done in this has resulted in conflicting conclusions regarding the abilities of individuals with DAT to process emotional information. The objective of the proposed research is to evaluate the emotion processing abilities of persons with DAT by utilizing psychophysiological and self-report measures of emotion while viewing and hearing emotion eliciting stimuli. The psychophysiological measures will include electromyogram recordings of corrugator supercillii, zygomaticus major, and orbicularis oculi muscle groups as well as skin conductance responses. Orbicularis oculi activity will be recorded to evaluate emotion-related startle reflex modulation. Self- report of emotional experience will be obtained with the Self- Assessment Manikin (SAM). Our hypotheses are that individuals with DAT will: 1) exhibit alterations in the processing of emotional information, evidenced by an attenuation of the emotion modulation of the eye-blink startle reflex response; 2) display alterations in the facial expression of emotions, with a reduction in positive emotional expressions and an increase in negative emotional expressions; 3) exhibit reduced emotion-related SCR; and 4) rate their subjective experiences of emotion similarly to the control group. The findings will provide for a better overall understanding of the experience of individuals with DAT, inform the literature on emotion-based communication with persons with DAT, and further elucidate potentials areas of concern for caregivers. This study will establish whether this technique is a valid means for measuring emotion in DAT, and will pave the way for future investigations of neural correlates of emotional processes.

这项研究的长期目标是评估患有阿尔茨海默氏症类型（DAT）痴呆症患者的情绪处理能力。尽管现在已经知道与DAT相关的认知缺陷知之甚少，但对于疾病过程如何影响情绪相关的经历和行为，相对较少了解。许多人观察到，患有DAT的人表现出情感上的变化，包括可疑性，躁动和烦躁，这些变化部分助长了严重的护理人员困扰。但是，几位临床医生已经提出了有关如何在语言能力恶化后最好与DAT的人进行最好的交流的建议，这些建议包括招募使用情绪表达，这被认为保持相对完整。没有足够的证据支持情绪提示处理在DAT中保存的观念。在这方面做了什么工作，导致关于患有DAT的人处理情绪信息的能力的结论相互矛盾。拟议的研究的目的是通过利用心理生理学和自我报告情绪的措施在观看和听到情绪引发刺激的同时利用心理生理学和自我报告的措施来评估患者的情绪处理能力。心理生理措施将包括波纹器超壳，Zygomaticus Major和Orbicularis oculi肌肉群的肌电图记录以及皮肤电导反应。将记录Orbicularis Oculi活性以评估与情绪相关的惊吓反射调制。情感经历的自我报告将通过自评估Manikin（SAM）获得。我们的假设是，患有DAT的人将：1）在情感信息处理中表现出改变，这是通过衰减眼神惊叹反应反应的情绪调节的衰减所证明的； 2）表现出情绪表达的改变，降低了积极的情绪表情和负面情绪表情的增加； 3）表现出与情绪相关的SCR降低； 4）与对照组相似，对他们的主观经历进行评分。这些发现将提供对患有DAT的人的经历的更好的总体理解，告知文献有关与DAT的人的基于情绪的沟通，并进一步阐明了关注护理人员的潜在领域。这项研究将确定该技术是否是衡量DAT中情绪的有效手段，并将为未来研究情绪过程的神经相关性铺平道路。