X RAY GUIDED LASER THERAPY SYSTEM FOR BREAST CANCER

X 射线引导乳腺癌激光治疗系统

• 批准号: 2646457
• 负责人: EDWARD L SINOFSKY
• 金额: $ 9.95万
• 依托单位: CARDIOFOCUS, INC.
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-07-01 至 2000-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2646457
• 关键词: X ray; biomedical equipment development; breast neoplasms; clinical biomedical equipment; laser therapy; mammography; method development; neoplasm /cancer photoradiation therapy; photocoagulation therapy; stereotaxic techniques; swine

We seek to develop a technique to treat breast cancer tumors in a minimally invasive way. The tumors would be eradicated using laser energy to photocoagulate the lesion through an incisionless interstitial approach. This approach will be enhanced by the capabilities of a high resolution X-ray, stereotactically guided, system that can accurately locate the lesion in 3 dimensions and deliver a trocar/cannulae to that exact location. After delivery of a specially designed laser energy transparent cannulae to the treatment site, laser energy will be uniformly diffused to treat the lesion with hyperthermia/coagulation. Laser probes will be miniaturized to minimize insertion trauma. This is a technologic approach to concern facing the 184,000 U.S. women yearly, with breast cancer, who live in dread of disfigurement from mastectomy and lumpectomy. We propose to: design, build and test a laser energy diffusing system capable of being stereotactically delivered to safely deliver the energy needed to coagulate clinically relevant tumors, examine the feasibility of monitoring the extent of the coagulated volume with the high resolution X-ray system already in use, and test the combined systems in an ex-vivo- and in-vivo model. PROPOSED COMMERCIAL APPLICATION The focus on the issue of breast cancer, from the mammogram to the possibility of mastectomy or lumpectomy, is one of today's highest health care concerns. A system that could locate and simultaneously treat breast cancer tumors in a minimally invasive way would have huge commercial application.

我们试图开发一种治疗乳腺癌肿瘤的技术 微创方式。 使用激光消除肿瘤 通过无切口光凝病变的能量 间质方法。 这种方法将通过 高分辨率X射线的功能，立体定位指导，系统 可以准确地将病变定位在3个维度中并提供一个 Trocar/套管到那个确切的位置。 交付后 设计到治疗部位的激光透明套管激光器 能量将均匀扩散以用 高温/凝结。 激光探针将被微型化以最小化 插入创伤。 这是一种涉及184,000名美国妇女面临的技术方法 每年与乳腺癌一起生活，他们害怕 乳房切除术和乳房切除术。 我们建议：设计，构建和测试 激光能量扩散系统能够立体定位 交付以安全地提供凝结临床所需的能量 相关肿瘤，检查监测程度的可行性 与已经使用的高分辨率X射线系统凝结的音量， 并在体内和体内模型中测试组合系统。 拟议的商业应用 从乳房X线照片到乳腺癌问题的重点 乳房切除术或乳房切除术的可能性是当今最高的 医疗保健问题。 一个可以同时定位的系统 以微创的方式治疗乳腺癌肿瘤将具有巨大 商业应用。

项目成果

Thermal analysis of laser interstitial thermotherapy in ex vivo fibro-fatty tissue using exponential functions.

使用指数函数对离体纤维脂肪组织进行激光间质热疗的热分析。

• DOI: 10.1088/0031-9155/49/9/002
• 发表时间: 2004
• 期刊: Physics in medicine and biology
• 影响因子: 3.5
• 作者: SalasJr,Nelson;Manns,Fabrice;Milne,PeterJ;Denham,DavidB;Minhaj,AhmedM;Parel,Jean-Marie;Robinson,DavidS
• 通讯作者: Robinson,DavidS