DIRECTIONAL & ISOTROPIC DIFFUSING TIPS FOR LASER THERAPY

定向

• 批准号: 3493368
• 负责人: EDWARD L SINOFSKY
• 金额: $ 7.45万
• 依托单位: CARDIOFOCUS, INC.
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-02-01 至 1994-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3493368
• 关键词: animal tissue; biomedical equipment development; diffusion; fiber optics; laser therapy; phantom model; photolysis

New lasers, delivery systems, and photo-sensitizers have broadened horizons in the field of photo-medicine. The tissue's response is highly influenced by its optical properties as well as the geometry of the incident beam. Sometimes modification of the profile of the beam to match the volume of tissue involvement during procedure such as photodynamic and photothermal therapy is desired. Recently interest has developed in fiberoptics for contact surgery and uniform irradiation of tissue during photodynamic therapy. More recently, side emitting tips have been developed for directional irradiation during photothermal therapy. These tips are designed to reflect the laser beam at a 90 degree angle. If a large surface of tissue needs to be irradiated, one must position the tip with multiple laser exposure, aimed only at the untreated areas. Other diffusing tips have not been optimized for the delivery of tens of watts needed for coagulating large volumes. REM seeks to further develop a family of diffusing tips for directional and non-directional, isotropic distribution of laser light.It is proposed to optimize diffusing tips at 630 nm for PDT therapy, 800 and 940 nm light from laser diodes, and l.06um for photocoagulation therapy. These tips will be characterized in air, phantom media, and tissue samples to evaluate and optimize their performance.

新的激光器，递送系统和照片敏感器已扩大 照片中的地平线。 组织的反应很高 受其光学特性以及几何形状的影响 事件梁。有时修改光束匹配的轮廓 在手术过程中的组织参与体积，例如光动力和 需要光热治疗。 最近在纤维琴进行接触手术和 光动力疗法期间组织的均匀照射。最近， 已经开发了侧面发射尖端，以用于定向辐照 光热疗法。 这些技巧旨在反射激光束 以90度角。 如果需要大的组织表面 辐照，必须以多个激光暴露将尖端定位为 仅在未经处理的地区。 其他扩散的技巧尚未优化 用于递送大量大量所需的数十瓦。 REM试图进一步发展一个扩散的秘诀 和非方向性，各向同性的激光分布。 在630 nm处优化PDT疗法的扩散尖端，800和940 nm光 来自激光二极管和L.06UM用于光凝疗法。这些技巧 将以空气，幻影介质和组织样本为特征 评估并优化其性能。