CATHETER FOR SIMULATANEOUS MAPPING AND LASER ABLATION

用于同步标测和激光烧蚀的导管

基本信息

批准号：
2668746
负责人：
EDWARD L SINOFSKY
金额：
$ 36.79万
依托单位：
CARDIOFOCUS, INC.
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
起止时间：
1997-03-01 至 2000-02-29
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/2668746
关键词：
biomedical equipment development disease /disorder model dogs electrodes electrophysiology heart catheterization laser therapy lasers myocardium nonhuman therapy evaluation photocoagulation therapy tachycardia

项目摘要

Various energy sources have been used to "ablate" (coagulate) myocardium responsible for initiating or sustaining ventricular tachycardia. We propose to further refine a catheter system that initially detects the location responsible for the arrhythmia, and subsequently treats the area with an interstitial dose of diffused laser diode energy. Lasers have not been widely used to treat arrhythmias due to the high cost and complexity of the laser source, and lack of a laser catheter capable of creating a reproducible tissue response without directly radiating blood, forming coagulum or perforating the heart. The proposed technologies overcome these deficiencies. Experiments are designed to enhance delivery and facilitate catheter positioning, add safety features, further understand wavelength and dosimetry effects, improve mapping capability, and enhance deployment ergonomics. The catheter designs will be refined, fabricated, and tested to allow electrophysiologic monitoring, with subsequent ablation, when the source of tachycardia is located. This coagulation will be induced interstially by inserting a diffusing fiber intramyocardially. The diffusing tips spread the light in a cylindrical pattern which has advantages over bare end fibers currently being used. Recent innovations have enabled us to make reproducible, clinically relevant thermal lesions, percutaneously in a canine model, providing proof of principle of the applicability of the proposed technique.

各种能源已被用来“消融”（凝固）心肌负责引发或维持室性心动过速。我们建议进一步完善最初检测的导管系统这导致心律失常的位置，并随后进行治疗该地区具有间隙剂量的扩散激光二极管能量。激光尚未广泛用于治疗心律失常，原因是高的激光源的成本和复杂性，以及激光的缺乏导管能够产生可重复的组织反应，而无需直接放射血液、形成凝固物或刺穿心脏。这建议的技术克服了这些缺陷。实验旨在增强交付并促进导管定位，添加安全功能，进一步了解波长和剂量测定效果，提高绘图能力，并增强部署人体工程学。导管设计将经过改进、制造和测试，以允许电生理监测，随后进行消融，当来源心动过速位于。这种凝固会被诱导间隙地通过在心肌内插入扩散纤维。扩散的尖端以圆柱形图案传播光线，这比裸目前使用的末端纤维。最近的创新使我们能够在临床上制造可重复的相关的热损伤，在犬模型中经皮，提供所提出技术的适用性的原理证明。