REAL TIME HANDHELD NEAR INFRARED BREAST CANCER IMAGER

实时手持式近红外乳腺癌成像仪

• 批准号: 6142012
• 负责人: SHOKO NIOKA
• 金额: $ 10.34万
• 依托单位: OPTICAL DEVICES, INC.
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-01 至 2001-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6142012
• 关键词: bioimaging /biomedical imaging; biomedical equipment development; breast neoplasm /cancer diagnosis; diagnosis design /evaluation; early diagnosis; electrical property; imaging /visualization /scanning; infrared radiation; phantom model; portable biomedical equipment

The great need for a simple, efficacious, portable and affordable breast tumor detector is evidenced by all of the publications using other technologies that are immobile, expensive or inefficacious. Near infrared (NIR) technology using laser light sources at an optical window from 700-900 nm is shown to carry diagnostic value for early detection of breast cancer. Based on photon migration principle in highly scattering media like the breast, near infrared imaging technology exploits the optical properties of oxygenated and deoxygenated hemoglobin to localize the cancer tissue. It is a very well established fact that the cancerous tissue requires high levels of blood hence angiogenesis proceeds the early stages of the tumor. Near-infrared technology has been the only non-invasive system to image the excessive oxygen consumption and the inhomogeneous blood distribution in a tissue during cancerogenesis. Advances in sensor and detector technology has increased the resolution of this innovative technology to 5 mm. Our aim is to design and develop a hand-held instrument that is safe, economic and fast in diagnosing breast cancer at an early stage.The portability and affordability of the device will prove to be very helpful in pre-screening of the under represented population. This project proposes a hand-held, fast affordable, battery operated breast tumor detector. None of the characteristics of the parent instrument ACTM are sacrificed and the translational study made with the parent instrument should be applicable to this novel, hand-held instrument. Thus the impact is expected to be greatest on under-served, geographically inaccessible populations. PROPOSED COMMERCIAL APPLICATIONS: A hand-held Near Infra Red Imaging apparatus has great in clinic as well as in home usage. The basic technology developed here can be utilized for the following applications: Early detection of breast cancer, pre- screening of under served population, screening of patients in rural areas, decreasing the cost of breast cancer screening. Each Of the above application area covers a large segment of the population. We estimate that in a steady state 200,000 unit to be manufactured. We anticipate a manufacturing cost of $600 and a selling price of about $1200.

所有出版物都使用其他不动，昂贵或无效的技术证明了对简单，有效，便携式和负担得起的乳腺肿瘤探测器的巨大需求。从700-900 nm处的光学窗口上使用激光光源的近红外（NIR）技术显示出可及早发现乳腺癌的诊断价值。基于光子迁移原理在高度散射培养基（如乳房）中，近红外成像技术利用了氧化和脱氧血红蛋白的光学特性来定位癌症组织。癌组织需要高水平的血管生成是一个非常确定的事实，因此是肿瘤的早期阶段。近红外技术一直是唯一对癌发生过程中组织中过量消耗氧和不均匀血液分布的非侵入性系统。传感器和探测器技术的进步将这种创新技术的解决方案提高到5毫米。我们的目的是设计和开发一种安全，经济且在早期诊断乳腺癌方面具有安全性，经济和快速的手持仪器。该设备的可移植性和负担能力将非常有用，这对预先筛查了不足的人群。该项目提出了一个手持式，快速负担得起的电池操作的乳腺肿瘤探测器。父母仪器ACTM的特征都没有牺牲，用父仪器进行的翻译研究不应适用于这种小说，手持仪器。因此，在服务不足的，地理位置不足的人群中，这种影响预计将是最大的。拟议的商业应用：在诊所和家庭使用中，靠近的Instra Red Imaging设备的手持式供您使用。这里开发的基本技术可用于以下应用：乳腺癌的早期发现，预先筛查服务人群不足，筛查农村地区的患者，降低了乳腺癌筛查的成本。以上每个应用区域涵盖了大部分人口。我们估计在一个稳态中，要制造200,000个单位。我们预计制造成本为600美元，售价约为1200美元。