SPECTROSCOPY AND IMAGING OF HB IN FETAL BRAIN IN UTERO

子宫内胎儿大脑中 HB 的光谱学和成像

• 批准号: 6390063
• 负责人: SHOKO NIOKA
• 金额: $ 33.38万
• 依托单位: OPTICAL DEVICES, INC.
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-08-01 至 2005-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6390063
• 关键词: abdomen; bioengineering /biomedical engineering; bioimaging /biomedical imaging; biomedical equipment development; brain circulation; brain imaging /visualization /scanning; clinical biomedical equipment; clinical research; embryo /fetus hypoxia; embryo /fetus monitoring; female; gastrointestinal imaging /visualization; human pregnant subject; image processing; imaging /visualization /scanning; infrared spectrometry; oximetry; oxyhemoglobin; phantom model; pregnancy; prenatal diagnosis; sheep

The phase-II application describes a systematic approach for the optimization and validation of trans-abdominal, near infrared (NIR) imaging of fetal cerebral blood saturation in utero. The phase-I accomplishments and additional preliminary investigations, demonstrate that it is possible to measure and quantify photon migration through the fetal head in utero, using continuous wave, NIR technology. The goal of the phase-II effort is to further optimize the NIR technology in order to enable quantitative, trans-abdominal, NIR imaging. First, a model based iterative image reconstruction (MOBIIR) scheme, will be adapted and optimized in conjunction with experimental and theoretical models for measurement geometries and data types, appropriate for trans-abdominal, NIR imaging. Next, two, complementary, dual wavelength, NIR devices will be optimized for trans-abdominal, NIR imaging. The first instrument will be a frequency domain device, with multiple source-detector pairs. The amplitude attenuation and phase delay in the tissue, measured with this device, will be incorporated in the MOBIIR scheme to quantify the blood saturation of the maternal and fetal tissues. The second instrument is a previously developed, continuous wave device. The amplitude modulation due to the fetal and maternal arterial pulses, measured with this device, will be incorporated into an algorithm based on pulse oximetry to extract the maternal and fetal arterial blood saturation. The accuracy and sensitivity of the two devices and corresponding analysis schemes will be validated using the near-term, pregnant ewe model. The feasibility of performing trans-abdominal, NIR imaging of fetal cerebral blood saturation in utero, will be evaluated in near-term patients. PROPOSED COMMERCIAL APPLICATION: Trans-abdominal, NIR imaging has the potential to assess fetal well being in near term, patients and patients during early labor (prior to descent of the fetal head). Fetal cerebral blood saturation obtained from trans- abdominal, NIR imaging in near-term patients or from patients in early labor can be used as an analog to scalp pH (which is generally obtained later in labor) to determine whether less aggressive or more aggressive clinical intervention is required. A low reading indicating fetal compromise could warrant the need for a cesarean delivery, while a normal reading could allow for the normal progression of labor. Trans- abdominal, NIR imaging may be particularly useful in early labor because during this period, the clinician may be confronted with non-reassuring fetal testing, but is unable to perform an NST, BPP (generally believed to be uninterpretable in labor), fetal scalp pH or internal monitoring (which requires cervical dilatation). Preventing the cesarean delivery of uncompromised fetuses (both premature and mature) in this manner, could have tremendous economic and medical benefits in the health care of children and mothers.

第三阶段的应用描述了一种系统的方法，用于优化和验证子宫内胎儿大脑血液饱和的近红外（NIR）成像。 I期成就和其他初步研究表明，使用连续波，NIR技术，可以通过子宫内的胎儿来测量和量化光子迁移。 II期努力的目的是进一步优化NIR技术，以实现定量，腹部NIR成像。 首先，将基于模型的迭代图像重建（MOBIIR）方案与用于测量几何形状和数据类型的实验和理论模型一起进行调整和优化，适合于腹部NIR成像。 接下来，两个，互补的，双波长，NIR设备将被优化用于腹部NIR成像。 第一个仪器将是带有多个源检测对的频域设备。用该设备测量的组织中的幅度衰减和相位延迟将纳入Mobiir方案中，以量化母体和胎儿组织的血液饱和度。 第二个仪器是先前开发的连续波动装置。 用该设备测量的胎儿和母体动脉脉冲引起的幅度调节将基于脉搏血氧饱和度来掺入算法中，以提取母体和胎儿动脉血液饱和度。 两种设备的准确性和灵敏度和相应的分析方案将使用近期，怀孕的母系模型进行验证。 在近期患者中，将评估对子宫内胎儿血液饱和度进行腹部大脑血液饱和的NIR成像的可行性。拟议的商业应用：腹部，NIR成像有可能在近期（胎儿下降之前）在近期的胎儿健康中评估胎儿健康。 近期患者的腹腹部脑血液饱和度可用于近期患者的NIR成像或早期劳动中的患者可以用作对头皮pH的类似物（通常在劳动中获得的类似物），以确定是否需要较少的攻击性或更具侵略性的临床干预。 表明胎儿妥协的低读数可能需要剖宫产，而正常的读数可以允许正常的人工进展。 腹部NIR成像可能在早期劳动中特别有用，因为在此期间，临床医生可能面临非胎儿测试，但无法执行NST，BPP（通常认为在劳动中无法解释），胎儿头皮pH或内部监测（这需要休次骨质扩张）。 防止剖宫产以这种方式提供不妥协的胎儿（早产和成熟），可能会在儿童和母亲的卫生保健中具有巨大的经济和医疗益处。