PROSPECTIVE STUDY OF CHILDREN OF SCHIZOPHRENIC PARENTS

精神分裂症父母的孩子的前瞻性研究

• 批准号: 2674722
• 负责人: L ERLENMEYER-KIMLING
• 金额: $ 58.35万
• 依托单位: NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC
• 依托单位国家: 美国
• 财政年份: 1975
• 资助国家: 美国
• 起止时间: 1975-04-07 至 2002-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2674722
• 关键词: antibody; behavior prediction; behavioral /social science research tag; behavioral genetics; blood chemistry; case history; child (0-11); child psychology; clinical research; data collection methodology /evaluation; disease /disorder proneness /risk; family genetics; human subject; interview; longitudinal human study; mental health epidemiology; parents; phenotype; psychological tests; questionnaires; schizophrenia; siblings; stress proteins; telecommunications

This is the final phase of major data collection in the New York High- Risk Project (NYHRP), a multi-trait, multi-measurement, prospective study, in which two independent samples of offspring of schizophrenic, affectively ill and normal parents have been followed with repeated testing and clinical evaluations since ages 7 to 12 in 1971-72 or '77-'79. The initial goal was to identify early neurobiological predictors of schizophrenia. This goal has expanded as the field has evolved to focus on the problem of defining the full phenotypic complement of endophenotypic and clinical traits making up the schizophrenia spectrum. Although we will collect updated clinical, environmental and family history data in this phase, we will concentrate chiefly on rating and synthesizing the data amassed previously and integrating the different domains of variables (e.g., social and neurobehavioral measures) in the extensive analyses that will be needed to resolve the questions and hypotheses posed in this longitudinal study. Specifically, we will 1) rate, from our extensive files, accumulated social, environmental and psychological data on the approximately 350 offspring and their approximately 160 recently examined siblings; 2) prepare lifetime profiles on the offspring, using all sources of data; 3) array family pedigrees of the physical/mental (including Axis l diagnoses and Axis Il features) health histories on the parents, offspring, and second-degree relatives. We will collect additional data with: 4) mailed questionnaires to obtain "psychosis- proneness" and schizotypy scales on the offspring; 5) final Axis I and II diagnostic interviews with the younger sample (Sample B) and selected Sample A subjects; 6) blood samples to preserve DNA and for use in an assessment of serum anti-bodies for the heat-shock protein (hsp 60); and Z) continued annual telephone interviews with the offspring to update their own clinical and treatment histories, as well as their family histories of disorders. We will also: J8 continue to offer referral services to subjects seeking assistance. Most of all, we will 9) conduct a large number of data analyses focused on: comparing the potential of specified traits as indicators of the genetic liability to schizophrenia and as predictors of adulthood psychiatric conditions; such analyses will include construction of composite indices of traits and examination of sib-pair and other intra-pedigree comparisons as estimates of familial aggregation and segregation of the aforementioned traits.

这是纽约高中主要数据收集的最后阶段 风险项目 (NYHRP)，一个多特征、多测量、前瞻性的项目 研究中，两个独立的后代样本 对患有精神分裂症、情感疾病和正常的父母进行了追踪 从 7 岁到 12 岁开始进行反复测试和临床评估 1971-72 或 '77-'79。最初的目标是尽早确定 精神分裂症的神经生物学预测因素。这一目标已扩大为 该领域已经发展到专注于定义完整的问题 内表型和临床性状的表型互补 精神分裂症谱系上升。虽然我们会收集更新的 这一阶段的临床、环境和家族史数据，我们将 主要集中于对收集到的数据进行评级和综合 之前并整合不同的变量域（例如， 社会和神经行为测量）在广泛的分析中 需要解决本文中提出的问题和假设 纵向研究。具体来说，我们将 1) 从我们广泛的 档案、积累的社会、环境和心理数据 大约 350 个后代及其最近的大约 160 个 检查兄弟姐妹； 2) 准备后代的寿命概况，使用 所有数据来源； 3）身体/心理阵列家族谱系 （包括轴 l 诊断和轴 II 功能） 父母、子女和二级亲属。我们将收集 附加数据：4）邮寄问卷以获得“精神病- 后代的倾向”和精神分裂量表；5) 最终轴 I 和 II 对年轻样本（样本 B）进行诊断访谈 选定的样本 A 受试者； 6) 血液样本以保存 DNA 并用于 用于评估热休克蛋白血清抗体 （热休克蛋白 60）； Z) 继续进行年度电话采访 后代也可以更新自己的临床和治疗历史 作为他们的疾病家族史。我们还将：J8继续 为寻求帮助的受试者提供转介服务。最重要的是，我们 9）进行大量数据分析，重点是：比较 特定性状作为遗传倾向指标的潜力 精神分裂症和成年期精神疾病的预测因子； 此类分析将包括构建综合性状指数 以及对同胞对和其他谱系内比较的检查 对上述家庭聚集和隔离的估计 特征。