PROSPECTIVE STUDY OF CHILDREN OF SCHIZOPHRENIC PARENTS

精神分裂症父母的孩子的前瞻性研究

• 批准号: 3374788
• 负责人: L ERLENMEYER-KIMLING
• 金额: $ 50.57万
• 依托单位: NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC
• 依托单位国家: 美国
• 财政年份: 1975
• 资助国家: 美国
• 起止时间: 1975-04-07 至 1988-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3374788
• 关键词: behavioral genetics; biological information processing; catechol methyltransferase; child mental disorders; child psychology; disease /disorder proneness /risk; early diagnosis; interview; longitudinal human study; mental disorder diagnosis; mental disorder prevention; mental health epidemiology; middle childhood (6-11); parents; performance; psychological tests; psychophysiology; schizophrenia; sibling relations; socioenvironment

This is a proposal for a three-year renewal of a longitudinal program project on children of schizophrenic, depressed, or normal parents that has been ongoing since 1971. Major goals of the study have been concerned with the identification of early indicators of a liability to the development of schizophrenia or schizophrenia spectrum disorders or affective disorders. Two independent samples, each consisting of groups of children at risk for these disorders and a group at low risk for mental illness, are being followed until the subjects reach young adulthood to enable the investigators to trace the development of the subjects over a period of years and to relate psychobiological (i.e., attention and information processing, neuromotor functioning, and psychophysiological data) and behavioral variables studied in childhood to psychopathology emerging in adulthood. Sample A subjects have recently been examined (for the fourth time) in early adulthood. It is planned to conduct a fourth round of examinations on Sample B subjects in young adulthood, comparable to the recent assessment of Sample A. Further aims of the core project are to complete diagnostic ratings of psychiatric interviews conducted in the third examination of Sample B, to obtain final diagnostic assessments from a panel of three independent judges who will review lifetime data on the subjects blind with respect to parents' diagnoses, and to complete analyses of the data collected over the course of the entire study, including longitudinal analyses and cross-sample comparisons. Three subprojects are also proposed; each subproject will extend the data collection to the families of the main subjects in Sample A and Sample B. In Subproject l, personality disorder interviews will be conducted with the subjects and their nonpsychotic parents (spouses of patients or parents of the normal comparison subjects) to clarify the nature of spectrum disorders. In Subproject 2, family history interviews will be conducted with as many family members as possible to complete information needed for genetic analyses. In Subproject 3, siblings of the main subjects will be given the same clinical assessment battery as is administered to the main subjects at the time of their fourth round of examinations.

这是一项纵向计划续签三年的提案 针对患有精神分裂症、抑郁症或正常父母的孩子的项目 自 1971 年以来一直在进行。该研究的主要目标涉及 确定对发展负有责任的早期指标 精神分裂症或精神分裂症谱系障碍或情感障碍。 两个独立样本，每个样本由有风险的儿童组组成 这些疾病和精神疾病风险较低的群体正在被 一直到受试者成年后才能 调查人员追踪受试者在一段时间内的发展 年并将心理生物学（即注意力和信息）联系起来 处理、神经运动功能和心理生理数据）和 从童年时期研究的行为变量到后来出现的精神病理学 成年期。 样本 A 受试者最近已接受检查（第四次 时间）在成年早期。 计划对样品B进行第四轮检验 青年时期的受试者，与最近对样本的评估相当 A. 核心项目的进一步目标是完成诊断评级 在样本 B 的第三次检查中进行了精神病学访谈，以 从三个独立小组获得最终诊断评估 法官将盲审受试者的终生数据 父母的诊断，并完成对收集的数据的分析 整个研究过程，包括纵向分析和 跨样本比较。 还提出了三个子项目；每个子项目都会扩展数据 收集样本A和样本B中主要受试者的家庭。 在子项目 l 中，人格障碍访谈将与 受试者及其非精神病父母（患者的配偶或父母） 正常比较科目）以澄清频谱的性质 失调。 在子项目2中，将进行家族史访谈 与尽可能多的家庭成员一起完成所需的信息 遗传分析。 在子项目 3 中，主要受试者的兄弟姐妹将是 给予与主要管理人员相同的临床评估组 第四轮考试时的科目。