PROSPECTIVE STUDY OF CHILDREN OF SCHIZOPHRENIC PARENTS

精神分裂症父母的孩子的前瞻性研究

• 批准号: 3486358
• 负责人: L ERLENMEYER-KIMLING
• 金额: $ 56.35万
• 依托单位: NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC
• 依托单位国家: 美国
• 财政年份: 1975
• 资助国家: 美国
• 起止时间: 1975-04-07 至 1992-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3486358
• 关键词: behavioral genetics; biological information processing; catechol methyltransferase; child mental disorders; child psychology; clinical depression; disease /disorder proneness /risk; early diagnosis; human subject; interview; longitudinal human study; mental disorder diagnosis; mental disorder prevention; mental health epidemiology; middle childhood (6-11); parents; performance; personality disorders; psychobiology; psychological tests; psychosis; schizophrenia; siblings; socioenvironment

This is a proposal for a five-year renewal of a longitudinal project (the New York High-Risk Project) on children of schizophrenic, depressed or normal parents, which has been ongoing since 1971. Major goals of the sutdy have been concerned with the identification of early inbdicators of a liability to the development of schizophrenia or schizophrenis spectrum disorders. In the current grant period, the project was extended to include previuosly-not-studied siblings of the study children, and greater focus on the parents, and these additional subjects will continue to be studied in the renewal years. In the proposed renewal period, in whioch all subjects will be studied as adults, major goals are concerned with: (1) assessing early stages of illness in subjects who experience (or have recently experienced) a first episode of psychiatric disorder; (2) continuing to examine the concept of the schizophrenia spectrum, using our samples to attempt to define criteria with high sensitivity and specificity for relatives of schizophrenic probands; (3) continuing to study attentional and information processing (AIP) measures and smooth pursuit eye movements (SPEM) with respect to: the accuracy with which they predict to adult psychiatric disorders, their specificity for schizophrenia and related disorders, state-trait questions, and familial clustering; (4) updating diagnostic assessments on all family members; (5) carrying out a number of genetic analyses relating to differential risk estimates, and heritabilities and familial segregation of clinical features and of AIP and SPEM measures; (6) collecting blood samples to preserve DNA in the families of schizophrenic parents. Additionally, we hope to study possible buffers and stressors.

这是一项纵向更新五年的提案 项目（纽约高风险项目） 患有精神分裂症、抑郁症或正常的父母，这种情况一直持续 自 1971 年以来。该研究的主要目标一直关注 识别责任的早期迹象 精神分裂症或精神分裂症谱系障碍的发展。 在当前的资助期内，该项目已扩展至包括 研究儿童以前未曾研究过的兄弟姐妹，以及更大的兄弟姐妹 关注父母，这些额外的主题将继续 在更新的年份里进行研究。 在拟议的更新期内，所有科目都将 作为成人学习，主要目标涉及：（1）评估 经历过（或有过）的受试者处于疾病的早期阶段 最近经历过）首次发作的精神疾病； (2) 继续研究精神分裂症谱系的概念， 使用我们的样本来尝试定义高标准 精神分裂症患者亲属的敏感性和特异性 先证者； (3)继续研究注意力和信息 处理（AIP）测量和平滑追踪眼球运动（SPEM） 关于：他们对成人预测的准确性 精神疾病、精神分裂症的特异性以及 相关疾病、状态特质问题和家族聚集； (4) 更新所有家庭成员的诊断评估； (5) 进行一些与差异相关的遗传分析 风险估计、遗传力和家族隔离 临床特征以及 AIP 和 SPEM 测量； (6)收集 血液样本保存精神分裂症患者家属的 DNA 父母。 此外，我们希望研究可能的缓冲区和 压力源。