PROSPECTIVE STUDY OF CHILDREN OF SCHIZOPHRENIC PARENTS

精神分裂症父母的孩子的前瞻性研究

• 批准号: 2243903
• 负责人: L ERLENMEYER-KIMLING
• 金额: $ 64万
• 依托单位: NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC
• 依托单位国家: 美国
• 财政年份: 1975
• 资助国家: 美国
• 起止时间: 1975-04-07 至 1996-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2243903
• 关键词: behavioral genetics; biological information processing; catechol methyltransferase; child mental disorders; child psychology; clinical depression; disease /disorder proneness /risk; early diagnosis; family genetics; human subject; interview; longitudinal human study; mental disorder diagnosis; mental disorder prevention; mental health epidemiology; middle childhood (6-11); parents; performance; personality disorders; psychobiology; psychological tests; psychosis; schizophrenia; siblings; smooth pursuit eye movement; socioenvironment

This is a proposal for a five-year renewal of a longitudinal project (the New York High-Risk Project) on children of schizophrenic, depressed or normal parents, which has been ongoing since 1971. Major goals of the sutdy have been concerned with the identification of early indicators of a liability to the development of schizophrenia or schizophrenis spectrum disorders. In the current grant period, the project was extended to include previuosly-not-studied siblings of the study children, and greater focus on the parents, and these additional subjects will continue to be studied in the renewal years. In the proposed renewal period, in which all subjects will be studied as adults, major goals are concerned with: (1) assessing early stages of illness in subjects who experience (or have recently experienced) a first episode of psychiatric disorder; (2) continuing to examine the concept of the schizophrenia spectrum, using our samples to attempt to define criteria with high sensitivity and specificity for relatives of schizophrenic probands; (3) continuing to study attentional and information processing (AIP) measures and smooth pursuit eye movements (SPEM) with respect to: the accuracy with which they predict to adult psychiatric disorders, their specificity for schizophrenia and related disorders, state-trait questions, and familial clustering; (4) updating diagnostic assessments on all family members; (5) carrying out a number of genetic analyses relating to differential risk estimates, and heritabilities and familial segregation of clinical features and of AIP and SPEM measures; (6) collecting blood samples to preserve DNA in the families of schizophrenic parents. Additionally, we hope to study possible buffers and stressors.

这是一项纵向项目五年更新的提案（ 纽约高风险项目）针对精神分裂症、抑郁症或抑郁症儿童 正常父母，自 1971 年以来一直在进行。主要目标 萨迪一直致力于识别早期指标 发展为精神分裂症或精神分裂症谱系的责任 失调。 在当前资助期内，该项目已延长至 包括研究儿童以前未研究的兄弟姐妹，以及更多 重点放在父母身上，这些额外的主题将继续 在更新年代学习。 在拟议的更新期内，所有科目都将作为 成人的主要目标涉及：（1）评估早期阶段 第一次经历（或最近经历过）的受试者的疾病 精神障碍发作； (2) 继续审视概念 精神分裂症谱系，使用我们的样本尝试定义标准 对精神分裂症患者亲属具有高敏感性和特异性 先证者； (3)继续研究注意力和信息处理 (AIP) 测量和平滑追踪眼球运动 (SPEM)： 他们预测成人精神疾病的准确性 精神分裂症和相关疾病的特异性、状态特质问题、 和家族聚集； (4)更新所有家庭的诊断评估 会员； (5) 进行多项遗传分析 差异风险估计、遗传力和家族隔离 临床特征以及 AIP 和 SPEM 测量； (6)采血 保存精神分裂症父母家庭 DNA 的样本。 此外，我们希望研究可能的缓冲和压力源。