SIMULTANEOUS X-RAY AND EMISSION COMPUTED TOMOGRAPHY

同时进行 X 射线和发射计算机断层扫描

• 批准号: 2712716
• 负责人: NEAL H CLINTHORNE
• 金额: $ 17.18万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-06-01 至 2000-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2712716
• 关键词: X ray; biomedical equipment development; computed axial tomography; diagnosis design /evaluation; positron emission tomography; tomography

DESCRIPTION (Adapted from Applicant's Abstract): The long term objective of this work is to provide the capability of performing x-ray transmission CT imaging nearly simultaneously with PET imaging. This will provide improved data for attenuation correction and will greatly reduce what has been a primary source of error in PET reconstructions. If the quality of transmission CT data is high, reconstructed images will be useful as guides for precisely determining anatomic sites of radiotracer uptake. Additionally, reconstructed images may be useful as guides for precisely determining anatomic sites of radiotracer uptake. These anatomic maps would be an extremely useful adjunct to tumor images acquired using PET in conjunction with 18FDG. Emphasis will be on developing a low-cost approach; specifically, cone-beam scanning using a low-power x-ray source in conjunction with an amorphous silicon imaging detector will be investigated. Amorphous silicon detector arrays are the largest pixellated imaging devices presently built. They are based on the same technology as that used to create active-matrix flat-panel displays. The specific aims are 1) evaluate and optimize performance of amorphous silicon imaging arrays for x-ray transmission CT; 2) implement appropriate cone-beam scanning and reconstruction techniques; 3) develop methods for estimating PET attenuation correction factors from x-ray CT data with particular emphasis on minimizing necessary x-ray dose. The goal for the present project period is to demonstrate the feasibility of this concept and to develop and validate techniques that will be used to design a prototype of a combined x-ray CT and PET system in a subsequent project period. Results of this investigation will have application to oncology and may have application for both SPECT and radiotherapy treatment.

描述（改编自申请人的摘要）： 这项工作是提供执行X射线传输CT的能力 与宠物成像同时成像。 这将提供改进的 用于衰减校正的数据，将大大减少 PET重建的主要误差来源。 如果质量 传输CT数据很高，重建图像将作为指南有用 用于精确确定放射性示意剂摄取的解剖部位。 此外，重建的图像可能可作为准确的指南 确定放射性示例摄取的解剖部位。 这些解剖图会 是使用PET获取的肿瘤图像非常有用的辅助 与18fdg结合。 重点是开发低成本的方法； 具体而言，使用低功率X射线源扫描锥形梁扫描 将研究与无定形硅成像检测器的结合。 无定形硅检测器阵列是最大的像素成像设备 目前建造。 它们基于与以前相同的技术 创建Active-Matrix Flat-Panel显示器。 具体目的是1）评估 并优化X射线的无定形硅成像阵列的性能 传输CT; 2）实施适当的锥形梁扫描和 重建技术； 3）开发估计宠物衰减的方法 X射线CT数据的校正因子特别强调最小化 必要的X射线剂量。 当前项目期间的目标是 证明此概念的可行性并发展和验证 将用于设计组合X射线CT的原型的技术 和随后的项目期间的宠物系统。 结果 调查将适用于肿瘤学，并可能提出 SPECT和放射疗法治疗。