COMPTON IMAGING PROBE FOR THE PROSTATE

康普顿前列腺成像探头

• 批准号: 6378138
• 负责人: NEAL H CLINTHORNE
• 金额: $ 14.91万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-20 至 2002-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6378138
• 关键词: bioimaging /biomedical imaging; biomedical equipment development; clinical research; human subject; immunoconjugates; indium; iodine; monoclonal antibody; neoplasm /cancer radionuclide diagnosis; phantom model; prostate neoplasms; radiation detector; radionuclides; technetium

The long-term objective of this R21/R33 investigation is to develop a new nuclear medicine imaging probe for the prostate based on the idea of the Compton scatter camera. When placed close to the organ of interest the probe can achieve high spatial resolution and high counting efficiency simultaneously, and unlike the conventional Compton camera, probes are not significantly influenced by the effects of Doppler broadening. Because of its proximity to the object, the Compton probe Can be small and therefore relatively inexpensive in comparison to a Compton camera for body imaging. In the R21 phase, the possibility for this probe to outperform conventional PET and SPECT instrumentation for prostate imaging will be examined. Performance of the probe and conventional systems for imaging the prostate will be quantified using several measures including the uniform Cramer-Rao bound, the ideal observer, and the channelized Hotelling observer. A prototype probe will be constructed using existing silicon detectors and the C-SPRINT Compton camera. Statistics from phantom measurements using the probe will be used to corroborate predictions of the performance measures. ff the investigation indicates that the probe provides significantly better images of the prostate, full-scale development of the Compton probe and preliminary patient imaging studies will be conducted in the R33 phase. Encouraging results in R33 will stimulate commercialization.

这项R21/R33研究的长期目标是根据康普顿散点摄像头的概念为前列腺开发新的核医学成像探针。当靠近感兴趣的器官时，探测器可以同时实现高空间分辨率和高计数效率，并且与常规的康普顿摄像机不同，探针不会受到多普勒拓宽影响的显着影响。由于它靠近物体，与康普顿摄像头相比，康普顿探针可能很小，因此相对便宜。在R21阶段，将检查该探针胜过常规PET和光谱仪器的前列腺成像的可能性。将使用多种措施来量化用于成像前列腺的探针和常规系统的性能，包括统一的Cramer-Rao结合，理想的观察者和通道的Hotelling观察者。将使用现有的硅探测器和C-Sprint Compton相机构建原型探针。 使用探针测量的统计数据将用于证实对性能度量的预测。 FF调查表明，该探针在R33阶段将进行探针的前列腺，全尺度开发和初步患者成像研究的明显更好图像。令人鼓舞的R33结果将刺激商业化。