Monitoring sarcopenic obesity in the elderly

监测老年人的肌肉减少性肥胖

• 批准号: 7126046
• 负责人: JOSEPH J KEHAYIAS
• 金额: $ 19.29万
• 依托单位: TUFTS UNIVERSITY BOSTON
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-30 至 2008-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7126046
• 关键词: X ray; bioengineering /biomedical engineering; biomedical equipment development; body composition; clinical biomedical equipment; clinical research; computed axial tomography; computer program /software; diagnosis quality /standard; field study; human old age (65+); human subject; muscle disorders; muscle function; patient monitoring device; photon absorptiometry; portable biomedical equipment; sarcopenia

DESCRIPTION (provided by applicant): Obesity in the elderly can be masked by body composition changes that result in a net weight loss. Sarcopenia, the loss of muscle and function with age, is universal in the elderly. The reduced protein stores inherent in sarcopenia leave the elderly with decreased ability to cope with illness or injury. The combination of increased %fat and sarcopenia results in a body composition status described as "sarcopenic obesity". This condition cannot be assessed by anthropometry or other traditional indirect body composition methods. The purpose of the proposed research is to develop and test a portable and relatively inexpensive instrument (X-ray absorptiometer) for carrying out body composition analysis of soft tissue in the field. These measurements are important for providing an index of nutritional status of individuals and will be used to evaluate the benefits and risks of anabolic treatments, nutritional support and the management of obesity in children and adults. Being portable, inexpensive, and simple to use, the instrument will permit the evaluation of nutritional health status of individuals in their own environment. It will be particularly beneficial to those for whom access to hospitals is difficult or limited (e.g. elderly in nursing homes or assisted living) or in underdeveloped nations, where aggressive nutrition support programs are being evaluated. The design is based on single and dual energy X-ray absorptiometry (DXA), optimized for soft tissue. The instrument is a hand-held caliper with a collimated X-ray source and a detector. The use of a simple detector array will facilitate the positioning of the caliper. The instrument will be evaluated for both single and dual energy mode and will be tested against mid-thigh CT and reference whole body composition techniques. The outcome of this research will be a fully developed and tested instrument and a method for its use in the field. This portable instrument will be particularly useful for monitoring sarcopenic obesity in the elderly where existing simple methods (such as Body Mass Index) fail to identify the true level of adipose tissue and frailty.

描述（由申请人提供）： 老年人的肥胖可以被体内的变化掩盖，从而导致净体重减轻。肌肉减少症是老年人普遍存在的肌肉和功能随着年龄的增长。减少的肌肉减少植物固有的蛋白质储存使老年人应对疾病或受伤的能力降低。增加％脂肪和肌肉减少症的组合导致人体成分状态被描述为“肌肉减少肥胖”。无法通过人体测量法或其他传统的间接身体组成方法来评估这种情况。 拟议的研究的目的是开发和测试一种便携式且相对便宜的仪器（X射线吸收计），用于对田间软组织进行身体组成分析。这些测量对于提供个人营养状况指数很重要，并将用于评估儿童和成人的合成代谢治疗，营养支持和肥胖管理的益处和风险。该工具是便携式，廉价且易于使用的，将允许评估个人在自己的环境中的营养健康状况。对于那些难以或有限的医院的人（例如，在疗养院或辅助生活中的老年人）或在评估积极的营养支持计划的欠发达国家中，这将是特别有益的。该设计基于对软组织优化的单一和双能X射线吸收法（DXA）。该仪器是具有准直X射线源和检测器的手持式卡钳。简单检测器阵列的使用将有助于卡钳的位置。将对单个和双能模式进行评估该仪器，并将针对大腿中部CT和参考全身组成技术进行测试。这项研究的结果将是一种完全开发和测试的仪器，也是一种在该领域使用的方法。该便携式仪器对于监测老年人的肌肉减少肥胖特别有用，在老年人中，现有的简单方法（例如体重指数）无法识别脂肪组织和脆弱的真实水平。