REGULATION OF ENERGY PARTITIONING DURING WEIGHT CHANGE

重量变化过程中能量分配的调节

• 批准号: 2740955
• 负责人: TIMOTHY R NAGY
• 金额: $ 13.51万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-06-01 至 2003-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2740955
• 关键词: Rodentias; adipose tissue; bioenergetics; bioperiodicity; body composition; body physical activity; body weight; corticosterone; gene expression; leptin; messenger RNA; metabolism; photobiology; weight control

Collared lemmings are able to double their body weight and body fat content in response to a change in photoperiod. This occurs without a change in food intake. Photo-induced changes in body weight will be used to examine the temporal relationships among changes in energy expenditure (resting and activity) and fuel partitioning. In this revised application, it is proposed that both leptin and corticosterone may play important roles in the seasonal changes in body weight and body composition. It is hypothesized that during weight gain: 1) A decrease in resting energy expenditure will be associated with the early phase of weight gain, and a decrease in energy expenditure associated with physical activity will be associated with weight maintenance after weight gain; 2) increased metabolic efficiency (decreased expression of uncoupling protein mRNA) will cause the decrease in resting energy expenditure during the early phase of weight gain; 3) the photoperiod-induced decrease in corticosterone concentration will decrease ob mRNA expression, which in turn will decrease uncoupling protein mRNA expression. The converse will also be studied during weight loss in this model system. The results will shed light on the role of energy expenditure and energy partitioning on the regulation of body weight and body composition. The basic scientific information gained from this model should be useful for understanding the role of metabolic perturbations in the etiology of human obesity.

项圈旅鼠能够使体重和体脂增加一倍 响应光周期变化的内容。这种情况发生时无需 食物摄入量的变化。将利用光引起的体重变化 检查能量消耗变化之间的时间关系 （休息和活动）和燃料分配。在这个修改后的申请中， 有人提出，瘦素和皮质酮都可能发挥重要作用 体重和身体成分的季节性变化中的作用。这是 假设体重增加期间：1）静息能量减少 支出将与体重增加的早期阶段相关，并且 与体力活动相关的能量消耗将减少 与体重增加后的体重维持有关； 2）增加 代谢效率（解偶联蛋白 mRNA 表达减少） 会导致早期静息能量消耗减少 体重增加阶段； 3）光周期引起的减少 皮质酮浓度会降低 ob mRNA 的表达， 转会降低解偶联蛋白 mRNA 的表达。反之则将 在这个模型系统中也可以研究减肥过程中的情况。结果将 阐明能量消耗和能量分配的作用 体重和身体成分的调节。基本科学 从这个模型中获得的信息应该有助于理解 代谢扰动在人类肥胖病因学中的作用。