Core C - Comparative Organismal Energetics Core

核心 C - 比较有机体能量学核心

• 批准号: 10260428
• 负责人: TIMOTHY R NAGY
• 金额: $ 17.85万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-07-15 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10260428
• 关键词: Aging; Animal Model; Area; Behavior; Biochemical; Bioenergetics; Biological Aging; Biology of Aging; Body Composition; Caenorhabditis elegans; Communities; Complement; Daphnia; Development; Drosophila genus; Dual-Energy X-Ray Absorptiometry; Eating; Energy Metabolism; Equipment; Genetic; Human Resources; Institution; Intervention; Longevity; Magnetic Resonance; Measures; Methodology; Mission; Modeling; National Institute on Aging; Nutritional; Organism; Procedures; Research; Research Personnel; Resources; Rodent; Services; Shock; Training and Education; Zebrafish; animal model selection; base; behavioral outcome; comparative; energy balance; functional outcomes; healthspan; improved; instrumentation; microCT; novel; nutrition related genetics

Project Summary – Comparative Organismal Energetics Core The Comparative Organismal Energetics Core (Organismal Core) provides specialized expertise in the development and utilization of methodologies, state-of-the-art instrumentation and the selection of animal models to facilitate understanding the contribution of energetics to biological aging, including nutritional, genetic, and biochemical interventions that impact aging research. The Organismal Core is a unique resource for investigators, with services and resources not available elsewhere on campus and available to the broader (non-UAB) research community. The Organismal Core is ideally suited to measure energy acquisition, storage, and utilization in a variety of animal models including C. elegans, Daphnia, Drosophila, zebrafish, and rodents, thereby complementing the overall mission and theme of the UAB Nathan Shock Center (NSC). The Specific Aims of the Core are as follows: 1. To provide expertise in the area of energetics and body composition in comparative animal models of aging; 2. To provide state-of-the-art instrumentation and methodology for the determination of body composition across the lifespan (dual energy X-ray absorptiometry, quantitative magnetic resonance, and micro- computed tomography); 3. To provide state-of-the-art instrumentation and methodology for the determination of energy balance across the lifespan (food intake, energy expenditure, energy balance, and activity); 4. To provide state-of-the-art instrumentation and methodology for evaluating healthspan-associated behaviors across lifespan and species; 5. To develop new methodologies for assessing energetics/body composition where needed in current and novel organisms for aging research; 6. To provide education and training on procedures and pitfalls in comparative organismal energetics (both internal and external to UAB).

项目摘要 - 比较有机体能量学核心 比较有机体能量学核心（Organismal Core）提供以下领域的专业知识： 方法学、最先进仪器的开发和利用以及动物的选择 促进理解能量学对生物衰老的贡献的模型，包括营养、 影响衰老研究的遗传和生化干预措施是一种独特的资源。 对于研究人员来说，校园其他地方无法提供服务和资源，并且可供更广泛的人使用 （非 UAB）研究社区非常适合测量能量获取、存储、 以及在多种动物模型中的应用，包括线虫、水蚤、果蝇、斑马鱼和啮齿动物， 从而补充了 UAB 内森休克中心 (NSC) 的总体和使命主题。 核心的目标如下： 1. 提供比较动物模型中能量学和身体成分领域的专业知识 老化; 2. 提供最先进的仪器和方法来测定身体成分 整个生命周期（双能 X 射线吸收测定法、定量磁共振和微 计算机断层扫描）； 3. 提供最先进的仪器和方法来确定能量平衡 整个生命周期（食物摄入、能量消耗、能量平衡和活动）； 4. 提供最先进的仪器和方法来评估与健康寿命相关的 跨生命周期和物种的行为； 5. 在当前和未来需要时开发新的方法来评估能量/身体成分 用于衰老研究的新型生物体； 6. 提供有关比较生物能量学的程序和陷阱的教育和培训（两者） UAB 内部和外部）。