Animal Physiology Core

动物生理学核心

• 批准号: 10183230
• 负责人: TIMOTHY R NAGY
• 金额: $ 17.78万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10183230
• 关键词: Animal Model; Animals; Area; Biology; Blood Pressure; Blood Vessels; Body Composition; Body Temperature; Cardiometabolic Disease; Cardiovascular Physiology; Cardiovascular system; Chemicals; Clustered Regularly Interspaced Short Palindromic Repeats; Collaborations; Data; Diabetes Mellitus; Dual-Energy X-Ray Absorptiometry; Eating; Echocardiography; Equipment; Functional disorder; Funding; Gamma Rays; Generations; Genetically Modified Animals; Genotype; Glucose Clamp; Goals; Grant; Image; In Vitro; Indirect Calorimetry; Knock-in; Knock-out; Magnetic Resonance; Magnetic Resonance Imaging; Metabolic; Metabolic Diseases; Metabolism; Methodology; Methods; Miniaturization; Nature; Output; Phenotype; Physiology; Positron-Emission Tomography; Preparation; Process; Productivity; Publications; Reagent; Research; Research Personnel; Resources; Rodent; Rodent Model; Roentgen Rays; Services; Technology; Testing; Training; Transgenic Animals; Transgenic Organisms; Translational Research; Vascular Diseases; base; bioluminescence imaging; blood glucose regulation; cardiometabolism; cost effectiveness; cost efficient; design; energy balance; experimental study; fluorescence imaging; glucose tolerance; human disease; in vivo; instrumentation; insulin tolerance; metabolic rate; microCT; molecular imaging; monitoring device; single photon emission computed tomography; tool; translational pipeline

The Animal Physiology Core (APC) brings together four experts in the areas of integrative physiology, cardiovascular physiology, imaging, and animal models who serve as a core resource for the study of diabetes using rodent models. The methods and services reflect the DRC theme that diabetes is both a metabolic and vascular disease. The overall goal of the APC is to provide easy access to highly-specialized equipment and expertise to augment diabetes and cardiometabolic research quality and cost effectiveness. The APC incorporates expertise and current technology for both metabolism and vascular assessment, brought together in one core for combined applications by the user base. The Specific Aims of the APC are to: 1. Provide expertise in the use of animal models for diabetes and cardiometabolic disease research; 2. To provide state-of-the-art instrumentation and methodology for the determination of body composition, energy balance, glucose homeostasis, cardiovascular assessment, molecular imaging, and genetically modified animal models; 3. To provide cost-efficient services to Core users; and 4. To promote interactions among investigators and to provide training in animal models and phenotyping methods. Since the DRC APC was founded in 2008, the track record of utilization and productivity has been outstanding and is growing. The high quality, breadth, and cutting-edge nature of the Core’s technologies, and responsiveness to the evolving needs of our investigators, have resulted in high rates of utilization by the DRC research base. By promulgating high-quality services in small animal phenotyping, the Core is an important strength for assuring that research is promoted across the full spectrum of translational research. The productivity numbers and data in the core utilization table speak for themselves. During the last grant cycle, the APC has been extremely active in supporting diabetes and cardiovascular research. The APC has supported 145 funded projects from 77 UAB investigators. The data provided by the core became the basis of numerous federal grants and led to many high-quality publications.

动物生理核心（APC）汇集了四个专家 充当核心的生理学，心血管生理学，成像和动物模型 使用啮齿动物模型研究糖尿病的资源。方法和服务反映了 DRC主题是糖尿病既是代谢和血管疾病。总体目标 APC将轻松访问高度指定的设备和专业知识以增加 糖尿病和心脏代谢的研究质量和成本效益。 APC合并 代谢和血管评估的专业知识和当前技术都带来了 在一个核心中共同使用用户群的合并应用程序。 APC的具体目的是： 1。在使用动物模型的糖尿病和心脏代谢疾病方面提供专业知识 研究; 2。提供最新的仪器和方法来确定身体 组成，能量平衡，葡萄糖稳态，心血管评估， 分子成像和一般修饰的动物模型； 3。为核心用户提供成本效益的服务；和 4。促进研究人员之间的互动，并提供动物模型的培训 表型方法。 由于DRC APC成立于2008年，因此利用率和生产力的记录具有 他很出色，正在成长。高质量，广度和尖端的性质 核心的技术以及对调查人员不断发展的需求的反应， DRC研究基础导致了高利用率。通过颁布高质量 小动物表型的服务，核心是确保 在翻译研究的全部范围内促进了研究。生产力 核心利用表中的数字和数据不言而喻。在上一个赠款周期中， APC非常积极地支持糖尿病和心血管研究。这 APC支持来自77名UAB调查人员的145个资助项目。由 核心成为众多联邦赠款的基础，并导致了许​​多高质量的出版物。