Animal Physiology Core

动物生理学核心

基本信息

批准号：
10183230
负责人：
TIMOTHY R NAGY
金额：
$ 17.78万
依托单位：
UNIVERSITY OF ALABAMA AT BIRMINGHAM
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-04-01 至 2023-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10183230
关键词：
Animal Model Animals Area Biology Blood Pressure Blood Vessels Body Composition Body Temperature Cardiometabolic Disease Cardiovascular Physiology Cardiovascular system Chemicals Clustered Regularly Interspaced Short Palindromic Repeats Collaborations Data Diabetes Mellitus Dual-Energy X-Ray Absorptiometry Eating Echocardiography Equipment Functional disorder Funding Gamma Rays Generations Genetically Modified Animals Genotype Glucose Clamp Goals Grant Image In Vitro Indirect Calorimetry Knock-in Knock-out Magnetic Resonance Magnetic Resonance Imaging Metabolic Metabolic Diseases Metabolism Methodology Methods Miniaturization Nature Output Phenotype Physiology Positron-Emission Tomography Preparation Process Productivity Publications Reagent Research Research Personnel Resources Rodent Rodent Model Roentgen Rays Services Technology Testing Training Transgenic Animals Transgenic Organisms Translational Research Vascular Diseases base bioluminescence imaging blood glucose regulation cardiometabolism cost effectiveness cost efficient design energy balance experimental study fluorescence imaging glucose tolerance human disease in vivo instrumentation insulin tolerance metabolic rate microCT molecular imaging monitoring device single photon emission computed tomography tool translational pipeline

项目摘要

The Animal Physiology Core (APC) brings together four experts in the areas of integrative physiology, cardiovascular physiology, imaging, and animal models who serve as a core resource for the study of diabetes using rodent models. The methods and services reflect the DRC theme that diabetes is both a metabolic and vascular disease. The overall goal of the APC is to provide easy access to highly-specialized equipment and expertise to augment diabetes and cardiometabolic research quality and cost effectiveness. The APC incorporates expertise and current technology for both metabolism and vascular assessment, brought together in one core for combined applications by the user base. The Specific Aims of the APC are to: 1. Provide expertise in the use of animal models for diabetes and cardiometabolic disease research; 2. To provide state-of-the-art instrumentation and methodology for the determination of body composition, energy balance, glucose homeostasis, cardiovascular assessment, molecular imaging, and genetically modified animal models; 3. To provide cost-efficient services to Core users; and 4. To promote interactions among investigators and to provide training in animal models and phenotyping methods. Since the DRC APC was founded in 2008, the track record of utilization and productivity has been outstanding and is growing. The high quality, breadth, and cutting-edge nature of the Core’s technologies, and responsiveness to the evolving needs of our investigators, have resulted in high rates of utilization by the DRC research base. By promulgating high-quality services in small animal phenotyping, the Core is an important strength for assuring that research is promoted across the full spectrum of translational research. The productivity numbers and data in the core utilization table speak for themselves. During the last grant cycle, the APC has been extremely active in supporting diabetes and cardiovascular research. The APC has supported 145 funded projects from 77 UAB investigators. The data provided by the core became the basis of numerous federal grants and led to many high-quality publications.

动物生理学核心 (APC) 汇集了四位综合领域的专家生理学、心血管生理学、影像学、动物模型等为核心使用啮齿动物模型研究糖尿病的资源。方法和服务反映了 DRC主题认为糖尿病既是一种代谢疾病又是一种血管疾病。 APC 旨在提供轻松访问高度专业化的设备和专业知识，以增强 APC 整合了糖尿病和心脏代谢研究的质量和成本效益。新陈代谢和血管评估的专业知识和当前技术，带来了集中在一个核心中，供用户群组合应用程序。 APC 的具体目标是： 1. 提供糖尿病和心脏代谢疾病动物模型使用方面的专业知识研究; 2. 提供最先进的仪器和方法来测定身体成分、能量平衡、葡萄糖稳态、心血管评估、分子成像和转基因动物模型； 3. 为核心用户提供具有成本效益的服务；以及 4. 促进研究者之间的互动并提供动物模型和表型分析方法。自 DRC APC 于 2008 年成立以来，利用率和生产率的记录一直在不断提高其高品质、广度和前沿性一直很出色，并且正在不断增长。 Core 的技术以及对研究人员不断变化的需求的响应能力，通过发布高质量的内容，刚果民主共和国研究基地的利用率很高。小动物表型分析服务中，核心是确保研究涉及翻译促进研究的各个领域。核心利用率表中的数字和数据不言自明。 APC 一直非常积极地支持糖尿病和心血管研究。 APC 已资助了 77 名 UAB 研究人员的 145 个项目。数据由 UAB 提供。 core 成为众多联邦拨款的基础，并催生了许多高质量的出版物。