Core C: Comparative Organismal Energetics Core

核心 C：比较有机体能量学核心

• 批准号: 8958640
• 负责人: TIMOTHY R NAGY
• 金额: $ 8.67万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-07-15 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8958640
• 关键词: Aging; Animal Model; Area; Body Composition; Budgets; Caenorhabditis elegans; Country; Daphnia; Doctor of Philosophy; Drosophila genus; Dual-Energy X-Ray Absorptiometry; Eating; Energy Metabolism; Laboratories; Longevity; Magnetic Resonance; Measures; Methodology; Mission; Organism; Procedures; Research; Research Personnel; Resources; Rodent; Shock; Training and Education; X-Ray Computed Tomography; Zebrafish; comparative; energy balance; instrumentation; novel

The Comparative Organismal Energetics Core (COEC) provides specialized expertise in the use of animal models, methodologies, and state-of-the-art instrumentation to facilitate energetics and aging research. The COEC provides a unique resource for investigators, with capabilities to perform complete energy budget analysis under environmental conditions of the users' choosing. The core is ideally suited to measure energy acquisition, storage, and utilization in a variety of animal models including C. elegans, Daphnia, Drosophila, Zebrafish, and rodents, and synergizes nicely with the overall mission of the UAB Nathan Shock Center (NSC). Interactions with the other Cores in the UAB NSC will be extensive. The Specific Aims of the Core are: 1. To provide expertise in the area of energetics and body composition in comparative animal models of aging; 2. To provide state-of-the-art instrumentation and methodology for the determination of body composition across the lifespan (dual energy X-ray absorptiometry, quantitative magnetic resonance, and micro- computed tomography); 3. To provide state-of-the-art instrumentation and methodology for the determination of energy balance across the lifespan (food intake, energy expenditure, and activity); 4. Develop new methodologies for assessing energetics/body composition in novel organisms. 5. Provide education and training on procedures and pitfalls in comparative organismal energetics (both internal and external to UAB)

比较有机体能量学核心 (COEC) 提供动物使用方面的专业知识 促进能量学和衰老研究的模型、方法和最先进的仪器。这 COEC 为研究人员提供了独特的资源，具有执行完整能源预算的能力 根据用户选择的环境条件进行分析。该核心非常适合测量能量 多种动物模型的采集、储存和利用，包括秀丽隐杆线虫、水蚤、果蝇、 斑马鱼和啮齿动物，与 UAB 内森休克中心 (NSC) 的总体使命完美协同。 与 UAB NSC 中其他核心的互动将是广泛的。 核心的具体目标是： 1. 提供比较动物模型中能量学和身体成分领域的专业知识 老化; 2. 提供最先进的仪器和方法来测定身体成分 整个生命周期（双能 X 射线吸收测定法、定量磁共振和微 计算机断层扫描）； 3. 提供最先进的仪器和方法来确定能量平衡 整个生命周期（食物摄入、能量消耗和活动）； 4. 开发新的方法来评估新生物体的能量/身体成分。 5. 提供有关比较有机体能量学的程序和陷阱的教育和培训（两者） UAB 内部和外部）