Core C: Comparative Organismal Energetics Core

核心 C：比较有机体能量学核心

基本信息

批准号：
8958640
负责人：
TIMOTHY R NAGY
金额：
$ 8.67万
依托单位：
UNIVERSITY OF ALABAMA AT BIRMINGHAM
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-07-15 至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/8958640
关键词：
Aging Animal Model Area Body Composition Budgets Caenorhabditis elegans Country Daphnia Doctor of Philosophy Drosophila genus Dual-Energy X-Ray Absorptiometry Eating Energy Metabolism Laboratories Longevity Magnetic Resonance Measures Methodology Mission Organism Procedures Research Research Personnel Resources Rodent Shock Training and Education X-Ray Computed Tomography Zebrafish comparative energy balance instrumentation novel

Aging Animal Model Area Body Composition Budgets Caenorhabditis elegans Country Daphnia Doctor of Philosophy Drosophila genus Dual-Energy X-Ray Absorptiometry Eating Energy Metabolism Laboratories Longevity Magnetic Resonance Measures Methodology Mission Organism Procedures Research Research Personnel Resources Rodent Shock Training and Education X-Ray Computed Tomography Zebrafish comparative energy balance instrumentation novel

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项目摘要

The Comparative Organismal Energetics Core (COEC) provides specialized expertise in the use of animal models, methodologies, and state-of-the-art instrumentation to facilitate energetics and aging research. The COEC provides a unique resource for investigators, with capabilities to perform complete energy budget analysis under environmental conditions of the users' choosing. The core is ideally suited to measure energy acquisition, storage, and utilization in a variety of animal models including C. elegans, Daphnia, Drosophila, Zebrafish, and rodents, and synergizes nicely with the overall mission of the UAB Nathan Shock Center (NSC). Interactions with the other Cores in the UAB NSC will be extensive. The Specific Aims of the Core are: 1. To provide expertise in the area of energetics and body composition in comparative animal models of aging; 2. To provide state-of-the-art instrumentation and methodology for the determination of body composition across the lifespan (dual energy X-ray absorptiometry, quantitative magnetic resonance, and micro- computed tomography); 3. To provide state-of-the-art instrumentation and methodology for the determination of energy balance across the lifespan (food intake, energy expenditure, and activity); 4. Develop new methodologies for assessing energetics/body composition in novel organisms. 5. Provide education and training on procedures and pitfalls in comparative organismal energetics (both internal and external to UAB)

比较生物的能量核心（COEC）在动物的使用方面提供了专业的专业知识模型，方法和最先进的仪器，以促进能量学和衰老研究。这 COEC为调查人员提供了独特的资源，具有执行完整能源预算的能力用户选择的环境条件下的分析。核心非常适合测量能量在各种动物模型中的采集，存储和利用斑马鱼和啮齿动物，并与UAB Nathan Shock Center（NSC）的整体任务结合得很好。与UAB NSC中其他核心的相互作用将是广泛的。核心的具体目的是： 1。在比较动物模型中提供能量和身体组成领域的专业知识老化; 2。提供最新的仪器和方法来确定身体成分在整个寿命中计算机断层扫描）； 3。提供最先进的仪器和方法来确定能量平衡在整个寿命（食物摄入，能量消耗和活动）中； 4。开发用于评估新生物中能量/身体组成的新方法。 5。在比较有机体能量学中提供有关程序和陷阱的教育和培训（均 UAB内部和外部）