FREQUENCY DOMAIN TISSUE SPECTROMETER

频域组织光谱仪

• 批准号: 2546596
• 负责人: Beniamino Barbieri
• 金额: $ 28.14万
• 依托单位: ISS, INC.
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-09-01 至 1999-03-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2546596
• 关键词: biomedical equipment development; cardiovascular disorder diagnosis; clinical biomedical equipment; clinical research; diagnosis design /evaluation; early diagnosis; fiber optics; hemoglobin; human subject; laser spectrometry; light scattering; noninvasive diagnosis; oxygen transport; peripheral blood vessel disorder; respiratory oxygenation

During Phase I, we developed and built a compact, portable, Frequency- Domain Tissue Spectrometer. The instrument provides, in real time, the absolute values of the scattering and absorption coefficients of oxy- and deoxy-hemoglobin in tissues and, hence, the hemoglobin saturation and the total hemoglobin content. Selected researchers used the instrument for the study of tissue oxygenation in muscles of normal and dystrophic subjects, brain region, for the mapping of the optical parameters of breast and the study of peripheral vascular disease (PVD). Of the many potential applications of the new instrument, we choose the early detection of PVD for the Phase II continuation of this project. This choice is dictated by the importance of the problem and by the successful use of the instrument for PVD early detection during clinical tests. During the Phase II, IFS intends to expand the instrument capabilities, perform exhaustive laboratory tests, and build a clinical instrument for the study and the early detection of PVD. Practical feedback for the instrument development will be provided by climb studies conducted at the University of Texas, Dallas; research aspects related to the interaction of light with tissues will be studied at the University of Illinois at Urbana-Champaign. PROPOSED COMMERCIAL APPLICATION: Non-invasive, absolute measurement of oxygenation state of tissues and determination of blood volume. Determination of tissue absorption and scattering coefficients for accurate setting of laser power in surgery and photodynamic therapy. Assessment of drug delivery to target tissues.

在第一阶段，我们开发并制造了一个紧凑、便携式、频率- 域组织光谱仪。该仪器实时提供 氧和的散射和吸收系数的绝对值 组织中的脱氧血红蛋白，因此血红蛋白饱和度和 总血红蛋白含量。 选定的研究人员使用该仪器 正常和营养不良肌肉组织氧合的研究 受试者的大脑区域，用于绘制光学参数 乳房和周围血管疾病（PVD）的研究。众多之中 新仪器的潜在应用，我们选择早期 该项目二期延续的PVD检测。 这 选择取决于问题的重要性和成功的结果 在临床试验中使用该仪器进行PVD早期检测。 在第二阶段，IFS 打算扩展仪器功能， 进行详尽的实验室测试，并构建临床仪器 PVD 的研究和早期检测。 实际反馈 仪器开发将由在 德克萨斯大学达拉斯分校；与交互相关的研究方面 伊利诺伊大学将研究组织光的作用 厄巴纳-香槟。 拟议的商业应用：非侵入性、绝对测量 组织的氧合状态和血容量的测定。 组织吸收和散射系数的测定 在手术和光动力治疗中准确设置激光功率。 评估药物向靶组织的递送。