Functional Near Infrared Imaging System

功能性近红外成像系统

• 批准号: 6529374
• 负责人: Beniamino Barbieri
• 金额: $ 20.03万
• 依托单位: ISS, INC.
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-01 至 2004-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6529374
• 关键词: bioimaging /biomedical imaging; biomedical equipment development; brain electrical activity; brain imaging /visualization /scanning; brain mapping; clinical research; computer program /software; computer system design /evaluation; fiber optics; functional magnetic resonance imaging; hemodynamics; hemoglobin; human subject; infrared radiation; noninvasive diagnosis; optics; phantom model; photomultiplier; spectrometry; time resolved data; tomography; visual stimulus

DESCRIPTION (Provided by Applicant): ISS will develop a novel instrument for the non-invasive imaging of functional activation of the brain. The system will consist of novel hardware and software. The hardware will include 32 laser diode emitters, and 8 photomultiplier tube detectors. Novel features of the hardware will include a customized frequency synthesizer and a customized data acquisition card, both of which will significantly improve imaging performance over current equipment. The software will include real time video maps of multiple tissue properties (hemoglobin oxygen saturation, hemoglobin concentration, and tissue optical parameters). These maps will be generated from a variety of methods including calibrated frequency domain multiple distance (C-FDMD) method, absolute frequency domain multiple distance method, continuous wave differential path length method, and crossed source-detector (CSD) path method. This multiplicity of methods will allow maps which benefit from the special characteristics of each method, from the high quantitation of C-FDMD method to the high localization of the CSD method. The system will be tested on phantoms, and in human subjects in conjunction with functional Magnetic Resonance Imaging (fMRI). Upon completion of its design and test, the system will be the world's only commercially available research system for near infrared tissue hemoglobin dynamics imaging. PROPOSED COMMERCIAL APPLICATION: 1. Optical imaging of brain activation and localization of stimulated brain cellular aggregates; 2. Cognitive neuroscience; 3. Brain oxygenation monitoring during cardiac bypass surgery; 4. Sleep-apnea studies; 5. Attention deficit disorder investigations

描述（由申请人提供）：国际空间站将开发一种新型仪器 大脑功能激活的非侵入性成像。该系统将由新颖的硬件和软件组成。硬件将包括 32 个激光器 二极管发射器和8个光电倍增管探测器。的新颖特点 硬件将包括定制的频率合成器和定制的数据 采集卡，两者都将显着提高成像性能 过流设备。该软件将包括实时视频地图 多种组织特性（血红蛋白氧饱和度、血红蛋白 浓度和组织光学参数）。将生成这些地图 来自多种方法，包括校准频域倍数 距离（C-FDMD）法、绝对频域多重距离法、 连续波差分路径长度法和交叉源-检测器 （CSD）路径方法。这种方法的多样性将使地图受益 从每种方法的特殊性，从高定量 C-FDMD方法是CSD方法的高度国产化。该系统将 在模型上进行了测试，并在人类受试者中结合功能进行了测试 磁共振成像 (fMRI)。设计和测试完成后， 该系统将成为世界上唯一的商用研究系统 红外组织血红蛋白动力学成像。 拟议的商业应用： 1. 大脑激活的光学成像和受刺激的脑细胞聚集体的定位； 2.认知神经科学； 3.心脏搭桥手术时的脑氧合监测； 4. 睡眠呼吸暂停研究； 5. 注意力缺陷障碍调查