FREQUENCY-DOMAIN TISSUE SPECTROMETER

频域组织光谱仪

• 批准号: 3505492
• 负责人: Beniamino Barbieri
• 金额: $ 5万
• 依托单位: ISS, INC.
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-09-01 至 1994-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3505492
• 关键词: biomedical equipment development; oxygen tension; spectrometry; tissues

We are developing a novel kind of tissue spectrometer, which utilizes total scattered light to quantitatively and non-invasively measure the absorption and scattering coefficients in highly scattering media. The method is based on the use of a radio frequency-modulated light source. Measurement of phase shift and demodulation ratio are used to independently determine the scattering and absorption coefficients along the average path traveled by light in the tissue between this source and a detector. In our apparatus, the phase and demodulation can be accurately measured in real time on a millisecond time base. The important field of application of this tissue spectrometer is in medicine for measuring low concentrations of absorbing metabolites in tissues. In the proposed prototype, the modulated source consists of an array of laser diodes emitting at selected wavelengths relevant to the oxygenation state of the tissue. During Phase I of this project, a prototype instrument for research purposes will be assembled and tested both for integration of new components and limits of the technology. In Phase II absorption and scattering coefficients at different tissue locations will allow imaging of optical properties of tissues. Clinical tests will be performed at the end of Phase II.

我们正在开发一种新型的组织光谱仪，它利用 总散射光到定量和非侵入性测量 高度散射培养基中的吸收和散射系数。这 方法基于射频调节的光源的使用。 相移和解调率的测量用于 独立确定沿着散射和吸收系数 该来源和该源之间的组织中的光线传播的平均路径 检测器。在我们的设备中，可以准确地进行阶段和解调 实时以毫秒的时间基础进行测量。重要领域 该组织光谱仪的应用用于测量低 组织中吸收代谢物的浓度。在提议中 原型，调制源由一系列激光二极管组成 在与与氧合状态相关的选定波长处发射 组织。在该项目的第一阶段，一种原型工具 研究目的将进行组装和测试以集成新的 技术的组件和限制。在II期吸收和 在不同组织位置的散射系数将允许成像 组织的光学特性。临床测试将在 第二阶段结束。