Data Coordinating Center for the Pediatric Heart Network - MUSIC

儿科心脏网络数据协调中心 - MUSIC

• 批准号: 10541019
• 负责人: Julie Elaine Miller
• 金额: $ 265.36万
• 依托单位: NEW ENGLAND RESEARCH INSTITUTES, INC.
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-07-01 至 2024-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10541019
• 关键词: Arrhythmia; COVID-19; Cardiac; Childhood; Clinical; Cohort Studies; Coronary artery; Data; Data Collection; Data Coordinating Center; Development; Echocardiography; Electrocardiogram; Enrollment; Exercise Test; Heart; Hospitals; Information Dissemination; Laboratories; Left; Multisystem Inflammatory Syndrome in Children; Music; Onset of illness; Outcome; System; Time; Ventricular; cardiac magnetic resonance imaging; data dissemination

PROJECT SUMMARY/ABSTRACT MUSIC is an observational cohort study that utilizes routinely collected clinical and cardiac (electrocardiogram [EKG], echocardiogram, cardiac MRI [CMR], exercise testing) data to assess the association between multisystem inflammatory syndrome in children associated with COVID-19 (MIS-C) and cardiac outcomes within the first year after hospital discharge. The objective of the study is to determine the spectrum and time course of coronary artery involvement, left ventricular (LV) systolic function, and arrhythmias or conduction system disturbances within the first year from illness onset, and to define associated clinical and laboratory factors. Approximately 1200 subjects will be enrolled and followed for up to 5 years after initial onset. The Specific Aim of the DCC is to manage the MUSIC study development, launch, data collection and dissemination of results.

项目概要/摘要 MUSIC 是一项观察性队列研究，利用常规收集的临床和心脏（心电图） [EKG]、超声心动图、心脏 MRI [CMR]、运动测试）数据来评估之间的关联 与 COVID-19 (MIS-C) 相关的儿童多系统炎症综合征和心脏结局 出院后的第一年。研究的目的是确定频谱和时间进程 冠状动脉受累、左心室 (LV) 收缩功能以及心律失常或传导系统 发病后第一年内的紊乱，并确定相关的临床和实验室因素。 大约 1200 名受试者将被纳入研究，并在初次发病后进行长达 5 年的随访。具体目标 DCC 的职责是管理 MUSIC 研究的开发、启动、数据收集和结果传播。