2023 Muscle: Excitation-Contraction Coupling Gordon Research Conference and Gordon Research Seminar

2023肌肉：兴奋-收缩耦合戈登研究会议暨戈登研究研讨会

• 批准号: 10606049
• 负责人: Francisco J Alvarado
• 金额: $ 3.3万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-02-15 至 2024-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10606049
• 关键词: Address; American; Area; Arrhythmia; Awareness; Basic Science; Biophysics; COVID-19; Calcium; Cardiac; Clinical; Clinical Research; Communication; Communities; Consultations; Coupled; Coupling; Dedications; Development; Diabetes Mellitus; Discipline; Disease; Elements; Environment; Europe; Faculty; Female; Fostering; France; Functional disorder; Gender; Geographic Locations; Goals; Growth; Health; Heart; Heart failure; Homeostasis; Human; Individual; Institution; International; Ions; Italy; Knowledge; Leadership; Malignant hyperpyrexia due to anesthesia; Medical; Memory; Metabolism; Molecular; Muscle; Muscle Fatigue; Muscle function; Muscular Dystrophies; Myocardium; New Hampshire; New Zealand; Nuclear; Organelles; Participant; Pathologic; Persons; Pharmacology; Physiological; Physiology; Postdoctoral Fellow; Productivity; Protein Biochemistry; Proteins; Quality of life; Race; Relaxation; Research; Research Personnel; Role; Ryanodine Receptor Calcium Release Channel; Science; Scientist; Signal Transduction; Skeletal Muscle; Smooth Muscle; Stretching; Striated Muscles; Structure; Students; Therapeutic; Translational Research; Translations; Underrepresented Minority; Work; career; career development; college; comparative; innovation; insight; meetings; nano; nanoscale; notch protein; novel; novel therapeutic intervention; posters; professor; programs; receptor; skeletal; structural biology; success; symposium; translational medicine

ABSTRACT This proposal seeks partial support for the Gordon Research Conference (GRC) on Muscle Excitation- Contraction coupling (ECC). This is the only major national/international meeting on this important topic. For cardiac, skeletal and smooth muscle we will delve into normal physiological function, dysfunction in disease and potential therapeutics at levels from molecular biophysics, electrical and calcium-dependent signaling to integrated function. This GRC will meet June 4-9, 2023 at Colby-Sawyer College in New Hampshire. The program was developed in consultation with a broad advisory group of leaders in ECC research. This Group and the GRC are chaired by Drs. Donald M Bers (USA) and Ana Gómez (France). Support is also sought for an associated Gordon Research Seminar (GRS) that is led by and focused upon early stage investigators (ESIs; students, postdocs and new faculty). This GRS immediately precedes the GRC and is chaired by two ESIs (Michelle Munro in New Zealand, and Francisco Alvarado in the USA). The two overarching objectives of the GRC and GRS are to: 1) Assemble top-notch scientist-speakers and participants to share new breakthroughs, stimulate and participate in deep and broad discussions that span from molecular mechanisms to integrated physiology and pathophysiology in cardiac, skeletal and smooth muscle, and 2) Increase the visibility and leadership of junior ECC ESIs and inspire/motivate their research careers by providing an interactive informal forum in which to present their work and network. The 2023 ECC GRC will have ~37 speakers, ~6 shorter talks to highlight selected poster abstracts and ~18 topic discussion leaders. Scientific sessions will detail the structure-function of ECC at multiple scales ranging, from molecular level to the translation into new therapeutic strategies for ECC-related. Sessions include, 1) L-type Ca Channels, 2) Ryanodine Receptors, 3) IP3 Receptors and Nuclear Signaling, 4) Malignant Hyperthermia and CPVT-Arrhythmias, 5) Store-Operated Ca entry, TRP and stretch-activated channels, 6) Muscular Dystrophy and Diabetes, and 8) Heart Failure and Skeletal Muscle Fatigue. Cardiac, skeletal and smooth muscle will be discussed together to highlight similarities and differences to enhance understanding of each muscle type at molecular and muscle levels in health and disease. The GRS will help ESIs develop self-confidence and sense of community that will encourage their full engagement in formal and informal discussion with senior colleagues during the GRC. The GRC will highlight ESI presentations in several ways (short talks, Poster Flash talks and discussion co-leaders) that heighten the exposure of these junior investigators and their novel research. We expect to attract ~175 basic and clinical researchers across career stages, genders, races, heritages, research disciplines, institutions, and geographical locations. We aim to promote: 1) open dialogue and communication, 2) visibility and career development for ESIs, 3) substantial new and deep knowledge about how muscle functions normally, what goes wrong in disease and what novel therapeutic strategies may benefit those afflicted by numerous diseases.

抽象的 该提案寻求戈登肌肉兴奋研究会议（GRC）的部分支持- 收缩耦合（ECC）是关于这一重要主题的唯一的大型国内/国际会议。 我们将深入研究心脏、骨骼和平滑肌的正常生理功能、疾病中的功能障碍和 从分子生物物理学、电和钙依赖性信号传导到 该 GRC 将于 2023 年 6 月 4 日至 9 日在新罕布什尔州科尔比索耶学院举行会议。 该计划是在与 ECC 研究领导者广泛咨询小组协商后制定的。 GRC 的主席是 Donald M Bers 博士（美国）和 Ana Gómez（法国）。 相关的戈登研究研讨会 (GRS) 由早期研究人员 (ESI; 该 GRS 紧接在 GRC 之前，由两个 ESI 主持。 （新西兰的米歇尔·蒙罗（Michelle Munro）和美国的弗朗西斯科·阿尔瓦拉多（Francisco Alvarado））。 GRC 和 GRS 的目标是： 1) 聚集顶尖科学家演讲者和参与者分享新突破， 激发并参与从分子机制到综合的深入而广泛的讨论 心脏、骨骼和平滑肌的生理学和病理生理学，以及 2) 提高可见性和 初级 ECC ESI 的领导力，并通过提供互动的非正式活动来激发/激励他们的研究生涯 展示他们的工作和网络的论坛，2023 年 ECC GRC 将有约 37 名演讲者，约 6 场简短的演讲。 重点介绍选定的海报摘要和约 18 个主题讨论的领导者将详细介绍这些内容。 ECC在多个尺度上的结构-功能，从分子水平到转化为新的治疗方法 ECC 相关的策略包括，1) L 型 Ca 通道，2) Ryanodine 受体，3) IP3 受体。 和核信号传导，4) 恶性高热和 CPVT 心律失常，5) 钙池操作钙内流，TRP 和拉伸激活通道，6) 肌营养不良症和糖尿病，以及 8) 心力衰竭和骨骼肌 将一起讨论心脏、骨骼和平滑肌，以突出相似点和差异。 增强对健康和疾病中每种肌肉类型的分子和肌肉水平的了解。 将帮助 ESI 培养自信和社区意识，鼓励他们充分参与 GRC 期间与高级同事进行正式和非正式讨论 GRC 将重点介绍 ESI 演讲。 通过多种方式（简短的演讲、海报快闪演讲和讨论共同领导者）来提高这些内容的曝光度 我们预计将吸引大约 175 名基础和临床研究人员。 我们的目标是职业阶段、性别、种族、传统、研究学科、机构和地理位置。 促进：1) 公开对话和交流，2) ESI 的知名度和职业发展，3) 实质性 关于肌肉如何正常运作、疾病中出现什么问题以及什么新奇的新而深入的知识 治疗策略可能会使那些受多种疾病影响的人受益。