Predictive Markers for Longitudinal TMJ Integrity

纵向颞下颌关节完整性的预测标记

• 批准号: 10648171
• 负责人: YOLY M GONZALEZ-STUCKER
• 金额: $ 17.99万
• 依托单位: STATE UNIVERSITY OF NEW YORK AT BUFFALO
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-05 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10648171
• 关键词: Address; Affect; American; Anatomy; Animal Model; Area; Arithmetic; Behavior; Biological Markers; Cephalic; Characteristics; Clinical; Consensus; Data; Data Set; Degenerative Disorder; Degenerative polyarthritis; Development; Diagnosis; Diagnostic; Disease Progression; Engineering; Environment; Failure; Fatigue; Female; Frequencies; Goals; Head; Health; High Prevalence; Hip region structure; Human; Image; Individual; Jaw; Joints; Knee; Length; Mandibular Condyle; Measurement; Measures; Mechanics; Medicine; Morphology; Muscle; National Institute of Dental and Craniofacial Research; Nickel; Occlusal Planes; Outcome; Pain; Patients; Pilot Projects; Predisposition; Psychophysiology; Publishing; Questionnaires; Reporting; Research; Risk; Risk Factors; Same-sex; Sex Differences; Structure; TMJ disk displacement; Temporomandibular Joint; Temporomandibular Joint Disorders; Testing; Time; Tissues; Translations; United States National Academy of Sciences; Work; articular cartilage; clinical practice; clinical translation; cohort; cone-beam computed tomography; cost; energy density; improved; joint loading; male; predictive marker; premature; tool

Project Summary/Abstract Temporomandibular disorders (TMDs) are prevalent, with estimates of 5% to 10%, with two-fold higher prevalence for females than males (NASEM, 2020), and projected annual costs of $4 billion (Stowell et al. 2007). TMD represents a group of conditions with and without pain, such as temporomandibular joint (TMJ) disc displacement and degenerative disease. Osseous changes are late-stage, degenerative characteristics (Farina et al. 2009; Luder 2002; Wiese et al. 2008) that tend to occur >10 years earlier in the TMJ than in other human joints. The long-term goals are to elucidate the variables responsible for precocious TMJ tissue failure and the predilection for females compared to males. TMJ tissue fatigue depends on applied mechanics and behavior; that is, magnitudes and frequencies of energy input to tissues. Published and preliminary data show that magnitudes and frequencies of energy input to TMJ tissues, quantified by Mechanobehavior Score (MBS, mJ∙%/mm3), predict longitudinal changes in TMJ structures. It was found that in 35 subjects over ≥5.3 years, TMJs where intracapsular diagnoses worsened had average MBS 8-times and 3-times greater than TMJs where diagnoses improved and remained stable, respectively. However, there are anatomical and psychophysiological variables that are more easily measured and clinically translatable. The Anatomic- Psychophysiologic Score (APS), the arithmetic product of these measures, correlated well with MBS. Therefore, the overall objective is to use an existing landmark data set from the TMJ Impact Project (Schiffman et al. 2017) to evaluate these markers (APS) to predict longitudinal changes in TMJ structures and intracapsular diagnoses over 8 years in 401 subjects (789 TMJs). The specific aims are to: (1) Determine if easily measured anatomical and psychophysiological variables predict conversion rate and direction of changes to TMJ structures associated with changes in intracapsular diagnoses, and if there are sex differences. (2) Test for sex differences in longitudinal changes in mandibular condyle volume within and between diagnostic groups. The outcomes of these specific aims will help to address the current needs identified by the National Academies of Sciences, Engineering, and Medicine 2020 consensus report for "new tools, metrics, and biomarkers to diagnose TMD and forecast their trajectory.”

项目概要/摘要 颞下颌关节紊乱病 (TMD) 很普遍，估计为 5% 至 10%，这一比例高出两倍 女性患病率高于男性（NASEM，2020），预计每年费用为 40 亿美元（Stowell 等，2020）。 2007）TMD 代表一组有或没有疼痛的病症，例如颞下颌关节（TMJ）。 椎间盘移位和退行性疾病是晚期退行性特征。 (Farina et al. 2009; Luder 2002; Wiese et al. 2008) 颞下颌关节的发生往往比其他部位早 10 年以上 人类关节的长期目标是阐明导致早熟颞下颌关节组织衰竭的变量。 与男性相比，女性的颞下颌关节组织疲劳程度取决于应用的力学和能力。 行为；即已发布的和初步的数据显示的能量输入的幅度和频率。 颞下颌关节组织能量输入的大小和频率，通过机械行为评分（MBS， mJ∙%/mm3)，预测 TMJ 结构的纵向变化 结果发现，在 35 名受试者中，时间超过 5.3 年， 囊内诊断恶化的 TMJ 的平均 MBS 分别是 TMJ 的 8 倍和 3 倍 诊断分别有所改善和保持稳定。 更容易测量和临床可转化的心理生理变量。 心理生理评分 (APS)，即这些测量值的算术乘积，与 MBS 密切相关。 因此，总体目标是使用 TMJ Impact Project（Schiffman et al. 2017）评估这些标记（APS）以预测 TMJ 结构的纵向变化 对 401 名受试者（789 名 TMJ）进行超过 8 年的囊内诊断，具体目标是： (1) 确定容易测量的解剖学和心理生理学变量是否可以预测转化率和 与囊内诊断变化相关的颞下颌关节结构变化方向，以及是否存在 性别差异。 (2) 检验内、外下颌髁突体积纵向变化的性别差异 诊断组。 这些具体目标的成果将有助于解决国家确定的当前需求 科学、工程和医学院 2020 年共识报告“新工具、指标和 诊断 TMD 并预测其轨迹的生物标记物。”