MIS-C Program: Data Coordinating Center for the Pediatric Heart Network MIS-C Program

MIS-C 计划：儿科心脏网络 MIS-C 计划数据协调中心

• 批准号: 10202823
• 负责人: Julie Elaine Miller
• 金额: $ 432.76万
• 依托单位: NEW ENGLAND RESEARCH INSTITUTES, INC.
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-04 至 2020-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10202823
• 关键词: 2019-nCoV; Address; Agreement; Budgets; COVID-19; Childhood; Clinical Trials Data Monitoring Committees; Cohort Studies; Data; Data Coordinating Center; Development; Electrocardiogram; Goals; Heart; Individual; Information Dissemination; Infrastructure; Knowledge; Laboratories; Leadership; Link; Logistics; Longterm Follow-up; Magnetic Resonance Imaging; Maintenance; Methods; Monitor; National Heart, Lung, and Blood Institute; Natural History; Outcome; Participant; Periodicity; Phenotype; Progress Reports; Protocols documentation; Research; Review Committee; Running; Services; Site; System; TimeLine; United States National Institutes of Health; Update; Work; cloud based; data integration; electronic data capture system; insurance claims; operation; payment; programs; recruit; social media; symposium; trial design; web site; webinar

PROJECT SUMMARY/ABSTRACT To address the knowledge gap discussed previously, NIH is initiating a national research program focused on pediatric SARS-CoV-2, COVID-19 and MIS-C. This goal of the program is to gain comprehensive understanding of phenotype, natural history, outcomes, and pathobiology of MIS-C. The Program will have several components including a MIS-C Cohort Study, adaptive design trials, long-term follow-up and a robust cloud-based data platform. The PHN DCC will serve to coordinate some of the components of the Program. The Specific Aims of the DCC are as follows: AIM 1: MANAGE CORE PROGRAM OPERATIONS AIM 2: MANAGE MIS-C COHORT STUDY DEVELOPMENT, LAUNCH, AND DISSEMINATION OF RESULTS AIM 3: PROVIDE SUPPORT SERVICES TO PROGRAM COMPONENTS

项目概要/摘要 为了解决前面讨论的知识差距，NIH 正在启动一项国家研究计划，重点关注 儿科 SARS-CoV-2、COVID-19 和 MIS-C。该计划的目标是获得全面的 了解 MIS-C 的表型、自然史、结果和病理学。该计划将有 多个组成部分，包括 MIS-C 队列研究、适应性设计试验、长期随访和稳健的研究 基于云的数据平台。 PHN DCC 将负责协调该计划的一些组成部分。 DCC的具体目标如下： 目标 1：管理核心计划运营 目标 2：管理 MIS-C 队列研究的开发、启动和传播 结果 目标 3：为程序组件提供支持服务