Development of high performance, caries-inhibiting dental nano-materials

高性能防龋牙科纳米材料的开发

• 批准号: 7581072
• 负责人: HUAKUN XU
• 金额: $ 26.25万
• 依托单位: UNIVERSITY OF MARYLAND BALTIMORE
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7581072
• 关键词: Accounting; Acids; Age; Area; Bone Tissue; Calcium Fluoride; Clinical; Composite Resins; Dental; Dental Materials; Dental caries; Dentistry; Development; Equation; Esthetics; Failure; Filler; Fluorides; Fracture; Generations; Glass; Goals; Human; In Vitro; Ions; Laboratories; Measures; Mechanics; Methods; Minerals; Modeling; Outcome; Particle Size; Performance; Plant Resins; Process; Property; Psychological reinforcement; Research; Resistance; Series; Solutions; Stress; Structure; Surface; Testing; Time; Tissue Engineering; Tooth structure; Vitremer; Water; Weight-Bearing state; Work; abstracting; acid stress; calcium phosphate; controlled release; cost; dental resin; design; dicalcium phosphate anhydrous; dimethyl 2,3,5,6-tetrachloroterephthalate; fighting; glass ionomer; improved; monocalcium phosphate; nano; nanocomposite; nanomaterials; nanoparticle; next generation; novel; particle; prevent; response; restoration; tetracalcium phosphate

DESCRIPTION (provided by applicant): Secondary caries and restoration fracture are the most frequent reasons for replacement of existing tooth restorations. Replacement dentistry accounts for 70% of all operative work and costs $5 billion/year in the US. In preliminary studies, nanoparticles of calcium phosphates (Ca-PO4) and calcium fluoride (CaF2) were synthesized for the first time and incorporated into dental resins. The objectives of the proposed research are to: (1) develop a new generation of stress-bearing, caries-inhibiting nancomposites; (2) determine the effects of nanoparticle sizes and compositions, and esthetic glass co-filler reinforcement; (3) design nanocomposites with tooth caries-inhibition capability exceeding current releasing restoratives, and long-term mechanical durability and wear that match current stress-bearing, non-releasing composite; and (4) establish nanocomposite processing methods and structure-performance relationships. AIM 1 will test the hypotheses that: (i) Decreasing the nanoparticle size will significantly increase the release to be much higher than a control composite containing traditional Ca-PO4 particles; (ii) Glass reinforcement will improve the nanocomposite strength, toughness and wear to match commercial stress-bearing, non-releasing composite, and to be 2-3 fold better than current releasing restoratives. AIM 2 will test the hypotheses that: (i) Fluoride release from nanocomposite is inversely proportional to CaF2 nanoparticle size, and is proportional to CaF2 volume fraction; (ii) Nanocomposites will have strength and toughness 2-3 fold greater than a resin-modified glass ionomer control, and wear depth 1/3 that of the control. AIM 3 will test the hypotheses that: (i) Tooth caries inhibition depends on nanoparticle size and composition; (ii) Nanocomposites, with much higher mechanical properties, can prevent tooth caries much more effectively than current releasing restoratives. AIM 4 will test the hypotheses that: (i) Mechanical response to water-aging and thermal-cycling will depend on nanoparticle size and composition; (ii) Nanocomposites, with Ca, PO4 and F release exceeding current releasing restoratives, will possess mechanical properties that match commercial stress-bearing, non-releasing composite, after 2 years of water-aging and thermal cycling; (iii) After water-aging/thermal cycling, nanocomposites will exceed the long-term ion release of the controls. The expected outcomes are: (1) A new generation of stress-bearing nanocomposites with release of high levels of cavity-fighting agents to inhibit tooth caries; (2) Significant impact on dentistry by overcoming the two major problems: secondary caries, and restoration failure; (3) Novel nanocomposite processing methods, structure-property relationships and models, that can be applied to dental and bone tissue engineering where stress-bearing and controlled-release capabilities are both important. PROJECT NARRATIVE: This project, utilizing novel nanoparticles synthesized in our laboratory for the first time, seeks to develop a new generation of stress-bearing, tooth caries-inhibiting nancomposites to overcome secondary caries, which is the major reason for replacement of existing restorations. Replacement dentistry accounts for 70% of all operative work and costs $5 billion/year in the US alone. Furthermore, this project will establish novel nanocomposite processing methods, structure-property relationships and models, which can benefit dental and bone tissue engineering where load-bearing and controlled-release capabilities are both important.

描述（由申请人提供）：次要龋齿和修复骨折是替换现有牙齿修复体的最常见原因。替代牙科占所有手术工作的70％，在美国占50亿美元。在初步研究中，首次合成了磷酸钙（CA-PO4）和氟化钙（CAF2）的纳米颗粒，并首次合成并掺入牙齿树脂中。拟议的研究的目标是：（1）发展新一代的承受压力，抑制龋齿的ancomposites； （2）确定纳米颗粒大小和成分的影响以及审美玻璃副填充剂的加固； （3）设计具有牙齿龋齿能力的纳米复合材料超过电流释放的恢复能力，以及与电流承受应力的，非释放复合材料相匹配的长期机械耐用性和磨损； （4）建立纳米复合处理方法和结构 - 性能关系。 AIM 1将测试以下假设：（i）降低纳米颗粒的大小将显着增加释放，比含有传统CA-PO4颗粒的对照复合材料高得多； （ii）玻璃加固将提高纳米复合材料的强度，韧性和磨损，以匹配商业压力，非释放复合材料，并且比目前释放的恢复效应要好2-3倍。 AIM 2将检验以下假设：（i）纳米复合材料释放氟化物与CAF2纳米颗粒的大小成反比，并且与Caf2体积分数成正比； （ii）纳米复合材料的强度和韧性将比树脂修饰的玻璃离子体控制大2-3倍，并佩戴对照的深度1/3。 AIM 3将检验以下假设：（i）龋齿抑制取决于纳米颗粒的大小和成分； （ii）具有更高机械性能的纳米复合材料可以比目前释放恢复剂更有效地防止龋齿。 AIM 4将检验以下假设：（i）对饮水和热循环的机械响应将取决于纳米颗粒的大小和组成； （ii）纳米复合材料，具有CA，PO4和F释放超过电流释放的恢复效应的纳米复合材料将具有与商业压力，不释放复合材料相匹配的机械性能，经过2年的饮水和热循环。 （iii）在水上/热循环后，纳米复合材料将超过对照的长期离子释放。预期的结果是：（1）新一代承受压力的纳米复合材料，释放高水平的腔剂剂以抑制龋齿； （2）克服两个主要问题：次要龋齿和恢复失败，对牙科的重大影响； （3）新型的纳米复合加工方法，结构 - 培训关系和模型，可以应用于牙科和骨组织工程，其中承受压力和控制释放的功能都很重要。 项目叙述：该项目是第一次利用我们实验室中合成的新型纳米颗粒，试图开发新一代的承受压力的，牙齿抑制鼻子的耐鼻孔来克服次要龋齿，这是替代现有修复的主要原因。替代牙科占所有手术工作的70％，仅在美国，占每年50亿美元的费用。此外，该项目将建立新颖的纳米复合加工方法，结构 - 培训关系和模型，这些方法可以使牙科和骨组织工程有益于承重和受控释放功能都很重要。