Development of high performance, caries-inhibiting dental nano-materials

高性能防龋牙科纳米材料的开发

基本信息

批准号：
8019588
负责人：
HUAKUN XU
金额：
$ 25.21万
依托单位：
UNIVERSITY OF MARYLAND BALTIMORE
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-04-01 至 2013-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8019588
关键词：
Accounting Acids Aging Area Bone Tissue Calcium Fluoride Clinical Composite Resins Dental Dental Materials Dental caries Dentistry Development Equation Esthetics Failure Filler Fluorides Fracture Generations Glass Goals Human In Vitro Ions Laboratories Measures Mechanics Methods Minerals Modeling Outcome Particle Size Performance Plant Resins Process Property Psychological reinforcement Research Resistance Series Solutions Stress Structure Surface Testing Time Tissue Engineering Tooth structure Vitremer Water Weight-Bearing state Work acid stress aged calcium phosphate controlled release cost dental resin design dicalcium phosphate anhydrous dimethyl 2,3,5,6-tetrachloroterephthalate fighting glass ionomer improved monocalcium phosphate nano nanocomposite nanomaterials nanoparticle next generation novel particle prevent response restoration tetracalcium phosphate

项目摘要

DESCRIPTION (provided by applicant): Secondary caries and restoration fracture are the most frequent reasons for replacement of existing tooth restorations. Replacement dentistry accounts for 70% of all operative work and costs $5 billion/year in the US. In preliminary studies, nanoparticles of calcium phosphates (Ca-PO4) and calcium fluoride (CaF2) were synthesized for the first time and incorporated into dental resins. The objectives of the proposed research are to: (1) develop a new generation of stress-bearing, caries-inhibiting nancomposites; (2) determine the effects of nanoparticle sizes and compositions, and esthetic glass co-filler reinforcement; (3) design nanocomposites with tooth caries-inhibition capability exceeding current releasing restoratives, and long-term mechanical durability and wear that match current stress-bearing, non-releasing composite; and (4) establish nanocomposite processing methods and structure-performance relationships. AIM 1 will test the hypotheses that: (i) Decreasing the nanoparticle size will significantly increase the release to be much higher than a control composite containing traditional Ca-PO4 particles; (ii) Glass reinforcement will improve the nanocomposite strength, toughness and wear to match commercial stress-bearing, non-releasing composite, and to be 2-3 fold better than current releasing restoratives. AIM 2 will test the hypotheses that: (i) Fluoride release from nanocomposite is inversely proportional to CaF2 nanoparticle size, and is proportional to CaF2 volume fraction; (ii) Nanocomposites will have strength and toughness 2-3 fold greater than a resin-modified glass ionomer control, and wear depth 1/3 that of the control. AIM 3 will test the hypotheses that: (i) Tooth caries inhibition depends on nanoparticle size and composition; (ii) Nanocomposites, with much higher mechanical properties, can prevent tooth caries much more effectively than current releasing restoratives. AIM 4 will test the hypotheses that: (i) Mechanical response to water-aging and thermal-cycling will depend on nanoparticle size and composition; (ii) Nanocomposites, with Ca, PO4 and F release exceeding current releasing restoratives, will possess mechanical properties that match commercial stress-bearing, non-releasing composite, after 2 years of water-aging and thermal cycling; (iii) After water-aging/thermal cycling, nanocomposites will exceed the long-term ion release of the controls. The expected outcomes are: (1) A new generation of stress-bearing nanocomposites with release of high levels of cavity-fighting agents to inhibit tooth caries; (2) Significant impact on dentistry by overcoming the two major problems: secondary caries, and restoration failure; (3) Novel nanocomposite processing methods, structure-property relationships and models, that can be applied to dental and bone tissue engineering where stress-bearing and controlled-release capabilities are both important. PROJECT NARRATIVE: This project, utilizing novel nanoparticles synthesized in our laboratory for the first time, seeks to develop a new generation of stress-bearing, tooth caries-inhibiting nancomposites to overcome secondary caries, which is the major reason for replacement of existing restorations. Replacement dentistry accounts for 70% of all operative work and costs $5 billion/year in the US alone. Furthermore, this project will establish novel nanocomposite processing methods, structure-property relationships and models, which can benefit dental and bone tissue engineering where load-bearing and controlled-release capabilities are both important.

描述（由申请人提供）：继发龋和修复体断裂是更换现有牙齿修复体的最常见原因。在美国，替换牙科占所有手术工作的 70%，每年花费 50 亿美元。在初步研究中，首次合成了磷酸钙（Ca-PO4）和氟化钙（CaF2）纳米颗粒并将其掺入牙科树脂中。本研究的目标是：（1）开发新一代承压、防龋纳米复合材料； (2) 确定纳米颗粒尺寸和成分以及美观玻璃辅助填料增强的影响； (3)设计纳米复合材料，其防龋能力超过电流释放修复剂，并且具有与当前承压、非释放复合材料相匹配的长期机械耐久性和耐磨性； (4)建立纳米复合材料加工方法和结构-性能关系。 AIM 1 将测试以下假设： (i) 减小纳米颗粒尺寸将显着增加释放量，远高于含有传统 Ca-PO4 颗粒的对照复合材料； (ii) 玻璃增强材料将提高纳米复合材料的强度、韧性和耐磨性，以匹配商业化的承压、非脱模复合材料，并且比现有的脱模修复剂好 2-3 倍。 AIM 2 将测试以下假设： (i) 纳米复合材料中氟化物的释放与 CaF2 纳米颗粒尺寸成反比，与 CaF2 体积分数成正比； (ii) 纳米复合材料的强度和韧性比树脂改性玻璃离聚物对照高 2-3 倍，磨损深度是对照的 1/3。 AIM 3 将测试以下假设： (i) 龋齿抑制取决于纳米颗粒的尺寸和成分； (ii) 纳米复合材料具有更高的机械性能，比目前的释放性修复材料更能有效地预防龋齿。 AIM 4 将测试以下假设： (i) 对水老化和热循环的机械响应将取决于纳米颗粒的尺寸和成分； (ii) 纳米复合材料的 Ca、PO4 和 F 释放量超过当前释放的修复剂，经过 2 年的水老化和热循环后，将具有与商业承压、非释放复合材料相匹配的机械性能； (iii) 水老化/热循环后，纳米复合材料将超过对照的长期离子释放量。预期成果是：（1）新一代承压纳米复合材料，可释放高水平的防蛀剂以抑制龋齿；（2）克服继发龋、修复失败两大难题，对牙科产生重大影响；（3）新型纳米复合材料加工方法、结构-性能关系和模型，可应用于压力承受和控制释放能力都很重要的牙科和骨组织工程。项目叙述：该项目首次利用我们实验室合成的新型纳米颗粒，旨在开发新一代的承压、抑制龋齿的纳米复合材料，以克服继发性龋齿，这是更换现有修复体的主要原因。置换牙科占所有手术工作的 70%，仅在美国每年就花费 50 亿美元。此外，该项目将建立新型纳米复合材料加工方法、结构-性能关系和模型，这将有利于牙科和骨组织工程，其中承载和控释能力都很重要。