Development of high performance, caries-inhibiting dental nano-materials

高性能防龋牙科纳米材料的开发

• 批准号: 7772339
• 负责人: HUAKUN XU
• 金额: $ 25.99万
• 依托单位: UNIVERSITY OF MARYLAND BALTIMORE
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7772339
• 关键词: Accounting; Acids; Age; Area; Bone Tissue; Calcium Fluoride; Clinical; Composite Resins; Dental; Dental Materials; Dental caries; Dentistry; Development; Equation; Esthetics; Failure; Filler; Fluorides; Fracture; Generations; Glass; Goals; Human; In Vitro; Ions; Laboratories; Measures; Mechanics; Methods; Minerals; Modeling; Outcome; Particle Size; Performance; Plant Resins; Process; Property; Psychological reinforcement; Research; Resistance; Series; Solutions; Stress; Structure; Surface; Testing; Time; Tissue Engineering; Tooth structure; Vitremer; Water; Weight-Bearing state; Work; acid stress; calcium phosphate; controlled release; cost; dental resin; design; dicalcium phosphate anhydrous; dimethyl 2,3,5,6-tetrachloroterephthalate; fighting; glass ionomer; improved; monocalcium phosphate; nano; nanocomposite; nanomaterials; nanoparticle; next generation; novel; particle; prevent; response; restoration; tetracalcium phosphate

DESCRIPTION (provided by applicant): Secondary caries and restoration fracture are the most frequent reasons for replacement of existing tooth restorations. Replacement dentistry accounts for 70% of all operative work and costs $5 billion/year in the US. In preliminary studies, nanoparticles of calcium phosphates (Ca-PO4) and calcium fluoride (CaF2) were synthesized for the first time and incorporated into dental resins. The objectives of the proposed research are to: (1) develop a new generation of stress-bearing, caries-inhibiting nancomposites; (2) determine the effects of nanoparticle sizes and compositions, and esthetic glass co-filler reinforcement; (3) design nanocomposites with tooth caries-inhibition capability exceeding current releasing restoratives, and long-term mechanical durability and wear that match current stress-bearing, non-releasing composite; and (4) establish nanocomposite processing methods and structure-performance relationships. AIM 1 will test the hypotheses that: (i) Decreasing the nanoparticle size will significantly increase the release to be much higher than a control composite containing traditional Ca-PO4 particles; (ii) Glass reinforcement will improve the nanocomposite strength, toughness and wear to match commercial stress-bearing, non-releasing composite, and to be 2-3 fold better than current releasing restoratives. AIM 2 will test the hypotheses that: (i) Fluoride release from nanocomposite is inversely proportional to CaF2 nanoparticle size, and is proportional to CaF2 volume fraction; (ii) Nanocomposites will have strength and toughness 2-3 fold greater than a resin-modified glass ionomer control, and wear depth 1/3 that of the control. AIM 3 will test the hypotheses that: (i) Tooth caries inhibition depends on nanoparticle size and composition; (ii) Nanocomposites, with much higher mechanical properties, can prevent tooth caries much more effectively than current releasing restoratives. AIM 4 will test the hypotheses that: (i) Mechanical response to water-aging and thermal-cycling will depend on nanoparticle size and composition; (ii) Nanocomposites, with Ca, PO4 and F release exceeding current releasing restoratives, will possess mechanical properties that match commercial stress-bearing, non-releasing composite, after 2 years of water-aging and thermal cycling; (iii) After water-aging/thermal cycling, nanocomposites will exceed the long-term ion release of the controls. The expected outcomes are: (1) A new generation of stress-bearing nanocomposites with release of high levels of cavity-fighting agents to inhibit tooth caries; (2) Significant impact on dentistry by overcoming the two major problems: secondary caries, and restoration failure; (3) Novel nanocomposite processing methods, structure-property relationships and models, that can be applied to dental and bone tissue engineering where stress-bearing and controlled-release capabilities are both important. PROJECT NARRATIVE: This project, utilizing novel nanoparticles synthesized in our laboratory for the first time, seeks to develop a new generation of stress-bearing, tooth caries-inhibiting nancomposites to overcome secondary caries, which is the major reason for replacement of existing restorations. Replacement dentistry accounts for 70% of all operative work and costs $5 billion/year in the US alone. Furthermore, this project will establish novel nanocomposite processing methods, structure-property relationships and models, which can benefit dental and bone tissue engineering where load-bearing and controlled-release capabilities are both important.

描述（由申请人提供）：继发龋和修复体断裂是更换现有牙齿修复体的最常见原因。在美国，替换牙科占所有手术工作的 70%，每年花费 50 亿美元。在初步研究中，首次合成了磷酸钙（Ca-PO4）和氟化钙（CaF2）纳米颗粒并将其掺入牙科树脂中。本研究的目标是：（1）开发新一代承压、防龋纳米复合材料； (2) 确定纳米颗粒尺寸和成分以及美观玻璃辅助填料增强的影响； (3)设计纳米复合材料，其防龋能力超过电流释放修复剂，并且具有与当前承压、非释放复合材料相匹配的长期机械耐久性和耐磨性； (4)建立纳米复合材料加工方法和结构-性能关系。 AIM 1 将测试以下假设： (i) 减小纳米颗粒尺寸将显着增加释放量，远高于含有传统 Ca-PO4 颗粒的对照复合材料； (ii) 玻璃增强材料将提高纳米复合材料的强度、韧性和耐磨性，以匹配商业化的承压、非脱模复合材料，并且比现有的脱模修复剂好 2-3 倍。 AIM 2 将测试以下假设： (i) 纳米复合材料中氟化物的释放与 CaF2 纳米颗粒尺寸成反比，与 CaF2 体积分数成正比； (ii) 纳米复合材料的强度和韧性比树脂改性玻璃离聚物对照高 2-3 倍，磨损深度是对照的 1/3。 AIM 3 将测试以下假设： (i) 龋齿抑制取决于纳米颗粒的尺寸和成分； (ii) 纳米复合材料具有更高的机械性能，比目前的释放性修复材料更能有效地预防龋齿。 AIM 4 将测试以下假设： (i) 对水老化和热循环的机械响应将取决于纳米颗粒的尺寸和成分； (ii) 纳米复合材料的 Ca、PO4 和 F 释放量超过当前释放的修复剂，经过 2 年的水老化和热循环后，将具有与商业承压、非释放复合材料相匹配的机械性能； (iii) 水老化/热循环后，纳米复合材料将超过对照的长期离子释放量。预期成果是：（1）新一代承压纳米复合材料，可释放高水平的防蛀剂以抑制龋齿； （2）克服继发龋、修复失败两大难题，对牙科产生重大影响； （3）新型纳米复合材料加工方法、结构-性能关系和模型，可应用于压力承受和控制释放能力都很重要的牙科和骨组织工程。 项目叙述：该项目首次利用我们实验室合成的新型纳米颗粒，旨在开发新一代的承压、抑制龋齿的纳米复合材料，以克服继发性龋齿，这是更换现有修复体的主要原因。置换牙科占所有手术工作的 70%，仅在美国每年就花费 50 亿美元。此外，该项目将建立新型纳米复合材料加工方法、结构-性能关系和模型，这将有利于牙科和骨组织工程，其中承载和控释能力都很重要。