Assessment of approach-avoidance motivation in neuropsychiatric disorders

神经精神疾病的接近-回避动机评估

基本信息

批准号：
10503869
负责人：
MICHAEL W. SCHLUND
金额：
$ 74.86万
依托单位：
GEORGIA STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-09-01 至 2027-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10503869
关键词：
Acute Adult Affect Affective Age Anhedonia Anterior Anxiety Area Behavior Behavioral Behavioral Paradigm Brain Characteristics Clinical assessments Cognition Cognitive Conflict (Psychology)Corpus striatum structure Data Development Diagnostic Disease Distress Dose Ecological momentary assessment Emotional Exhibits Foundations Frequencies Fright Functional disorder Future Goals Human Image Individual Instruction Insula of Reil Investigation Life Matched Group Measurement Measures Mental Depression Mental Health Methodology Modeling Moods Motivation Negative Valence Outcome Participant Persons Positive Valence Probability Property Psychometrics Psychoses Regression Analysis Reporting Research Research Domain Criteria Research Project Grants Rewards Severities Sex Differences Standardization System Testing Time Validity and Reliability Visual Work anxious approach avoidance behavior approach behavior avoidance behavior base behavioral response clinically significant cognitive control design emotion regulation flexibility innovation neuroimaging neuropsychiatric disorder psychosocial public health research recruit relating to nervous system response social social anxiety social learning stem theories user-friendly

项目摘要

ABSTRACT PAR-18-30 “Development and Optimization of Tasks and Measures for Functional Domains of Behavior” encourages research projects that will develop and optimize new or existing tasks and measures for the Research Domain Criteria (RDoC). This call stems from workgroups of the National Advisory Mental Health Council that identified significant gaps in the RDoC measurement toolkit. In the negative valence systems (NVS) domain, one priority area is the need for behavioral paradigms for identifying areas of overlap and distinction between NVS, which motivate defensive avoidance behaviors, and positive valence systems (PVS), which motivate reward-approach behaviors. We contend that approach-avoidance (AP-AV) paradigms offer a promising solution. AP-AV tasks are essentially behavioral approach tests that enable assessment of overt behavioral responses to acute threats. The aims of this proposal are to demonstrate the (1) psychometric adequacy (test-retest reliability) and (2) diagnostic/predictive validity of a user-friendly instructed AP-AV-task we’ve developed for assessing psychosocial dysfunction associated with anxiety, depression, psychosis, and other conditions. Our aims build upon extensive preliminary research in our lab devoted to optimizing task parameters, measures and administration. This work has the potential to yield an easy-to-use and widely disseminable AP-AV task for identifying areas of overlap and distinction between NVS and PVS, as well as a general AP-AV methodology that is adaptable for assessing overt behavioral responses to acute threats. To achieve these aims, we will recruit three matched groups of adults (healthy, elevated social anxiety, and elevated social anhedonia). Inclusion of groups with anxiety and anhedonia are necessary to assess diagnostic and predictive validity. Participants will complete standardized clinical assessments and complete the instructed AP-AV task multiple times during two neuroimaging sessions, separated by 10-14 days. Between imaging sessions, ecological momentary assessments (EMA) will capture mood, motivational level, frequency of real-life approach/avoidance, and emotional regulation strategy use. This research is theoretically significant because it highlights the relevance of theories of AP-AV motivation for research devoted to identifying areas of overlap and distinction between NVS and PVS. This research is methodologically innovative because it will produce a user-friendly AP-AV task with strong psychometric properties for use in behavioral (stand-alone) or neuroimaging research. Outcome data will also provide the necessary empirical foundation for future investigations into the suitability of AP-AV tasks for use with individuals who vary widely in age, ability, and/or severity of disorder.

抽象的 PAR-18-30“行为功能领域的任务和措施的制定和优化” 鼓励研究项目开发和优化新的或现有的任务和措施研究领域标准 (RDoC) 此呼吁源自国家心理健康咨询工作组。理事会发现了 RDoC 测量工具包中负价系统 (NVS) 的重大缺陷。领域，一个优先领域是需要行为范式来识别重叠和区别的领域激发防御性回避行为的 NVS 和正价系统 (PVS) 之间，我们认为，这会激发奖励接近行为（AP-AV）。 AP-AV 任务本质上是支持评估的行为方法测试。该提案的目的是证明 (1) 心理测量的充分性（重测可靠性）和（2）用户友好的诊断/预测有效性我们开发的指导性 AP-AV 任务用于评估与焦虑相关的心理社会功能障碍，我们的目标建立在我们广泛的初步研究的基础上。实验室致力于优化任务参数、措施和管理。这项工作有潜力。产生易于使用且可广泛传播的 AP-AV 任务，用于识别重叠和区别区域 NVS 和 PVS 之间的模型，以及适用于评估公开的 AP-AV 方法为了实现这些目标，我们将招募三组匹配的成年人。（健康、社交焦虑加剧以及社交快感缺乏）。快感缺乏对于评估诊断和预测的有效性是必要的，参与者将完成。标准化临床评估，并在两个期间多次完成指导的 AP-AV 任务神经影像检查，在影像检查之间间隔 10-14 天，进行生态瞬时检查。评估 (EMA) 将捕捉情绪、动机水平、现实生活中接近/回避的频率、这项研究具有重要的理论意义，因为它强调了情绪调节策略的使用。 AP-AV 动机理论与致力于识别重叠和区别领域的研究的相关性 NVS 和 PVS 之间的研究在方法上是创新的，因为它将产生一个用户友好的结果。 AP-AV 任务具有强大的心理测量特性，可用于行为（独立）或神经影像学研究结果数据也将为未来的调查提供必要的实证基础。 AP-AV 任务适用于年龄、能力和/或疾病严重程度差异很大的个体。