BOLD fMRI in MR research to map learning histories

MR 研究中的 BOLD fMRI 绘制学习历史

基本信息

批准号：
6805266
负责人：
MICHAEL W. SCHLUND
金额：
$ 8.05万
依托单位：
HUGO W. MOSER RES INST KENNEDY KRIEGER
依托单位国家：
美国
项目类别：
财政年份：
2003
资助国家：
美国
起止时间：
2003-09-26 至 2006-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6805266
关键词：
behavioral /social science research tag bioimaging /biomedical imaging brain imaging /visualization /scanning brain mapping clinical research conditioning functional magnetic resonance imaging human subject learning neural information processing oxygen tension reinforcer

项目摘要

DESCRIPTION (provided by applicant): Successful development and adaptation requires, in part, proper performances in terms of how to respond, when to respond, and what consequences may follow responding. Defining characteristics of developmental disabilities and mental retardation are deficits in responding appropriately to environmental stimuli associated with various contingencies. Primary among these are the learning requirements to reach proper levels of responding. To understand the neural substrates underlying learning processes in healthy adults, previous PET and fMRI investigations image brain regions during delivery of reinforcers or punishers. The extent to which similar brain regions are involved in discriminating among stimuli associated with different contingencies is unclear, but equally important to understanding the neural processes involved in learning. This application presents data from a preliminary investigation using BOLD fMRI to examine relations between a history of discrimination learning and neural patterns of activation in a small number of adult human subjects. Preliminary results show stimuli associated with a reinforcement contingency produced a wide range of activation patterns when contrasted with a stimulus not associated with a contingency. Before conducting studies comparing subjects with and without differing levels of mental retardation, the investigators need to replicate their preliminary work with a sufficient number of non-mental retardation subjects to determine the usefulness of the stimulus-based imaging approach in either differing between conditioning histories or identifying neural substrates that map these histories.

描述（由申请人提供）：成功的开发和适应部分需要在如何响应、何时响应以及响应可能产生的后果方面有适当的表现。发育障碍和精神发育迟滞的定义特征是对与各种突发事件相关的环境刺激做出适当反应的缺陷。其中最主要的是达到适当响应水平的学习要求。为了了解健康成年人学习过程的神经基质，之前的 PET 和功能磁共振成像研究对强化物或惩罚物传递过程中的大脑区域进行了成像。相似的大脑区域在多大程度上参与区分与不同偶然事件相关的刺激尚不清楚，但对于理解学习中涉及的神经过程同样重要。该应用程序提供了使用 BOLD fMRI 进行初步调查的数据，以检查少数成年人受试者的辨别学习历史与神经激活模式之间的关系。初步结果表明，与与意外事件无关的刺激相比，与强化意外事件相关的刺激产生了广泛的激活模式。在对患有和不患有不同程度的智力迟钝的受试者进行比较研究之前，研究人员需要用足够数量的非智力迟钝受试者重复他们的初步工作，以确定基于刺激的成像方法在条件反射历史或条件历史之间的差异中的有用性。识别映射这些历史的神经基质。