Cancer Prevention and Control Program

癌症预防和控制计划

基本信息

批准号：
10493587
负责人：
Edward F. Ellerbeck
金额：
$ 3.95万
依托单位：
UNIVERSITY OF KANSAS MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-07-11 至 2027-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10493587
关键词：
Address Advocacy Affect American Indians Area Award Behavior Behavioral Behavioral Sciences Biological Markers Biology Biometry Breast Cancer Burden Cancer Center Cancer Center Support Grant Cancer Control Cancer Control Research Cancer Control Research Program Cancer Patient Cancer Survivorship Caring Catchment Area Clinical Collaborations Communication Communities Community Outreach Community Practice Criminal Justice Data Science Detection Development Diagnosis Disadvantaged Discipline of Nursing Disease Disease Marker Disease Progression Economics Ensure Epidemiology Evidence based intervention Extramural Activities Faculty Fostering Funding Grant Guidelines Health Services Research Hereditary Malignant Neoplasm Hispanic Americans Immunization Incidence Individual Infrastructure Intervention Intervention Studies Kansas Lesion Longevity Malignant Neoplasms Mentorship Methods Mission Modeling Molecular Morbidity - disease rate NCI Scholars Program National Cancer Institute Neurosciences Nutritional Obesity Observational Study Oncology Pain management Pathway interactions Patients Persons Pharmacology Phase Physical activity Pilot Projects Policies Population Population Sciences Populations at Risk Positioning Attribute Pragmatic clinical trial Prevention Primary Cancer Prevention Primary Health Care Primary Prevention Principal Investigator Productivity Provider Public Health Publishing Recurrent Malignant Neoplasm Research Research Design Research Personnel Research Project Grants Risk Risk Factors Rural Rural Minority Schools Scientific Advances and Accomplishments Screening for cancer Services Smoking System Testing Training Translating Translational Research Translations Universities Work Writing anticancer research behavioral clinical trial biomarker-driven cancer biomarkers cancer care cancer complication cancer health disparity cancer prevention cancer risk cancer therapy care delivery clinical practice community engagement design effective intervention evidence base gastrointestinal hereditary risk high risk high risk population implementation science improved innovation member minority communities multidisciplinary novel nutrition physical inactivity population health practice setting pragmatic trial premalignant prevent programs rural African American student mentoring success support network survivorship telehealth tobacco control translational pipeline underserved minority visiting scholar working group

项目摘要

CANCER PREVENTION AND CONTROL: ABSTRACT The Cancer Prevention and Control (CPC) research program at The University of Kansas Cancer Center (KUCC) brings together an interdisciplinary team of researchers focused on: 1) developing, testing, and implementing innovative strategies to modify behaviors that drive cancer risk and disparities in cancer incidence (Population-Level Primary Prevention); 2) identifying biomarker-driven opportunities for cancer prevention among high-risk individuals with premalignant disease or hereditary cancer risk and testing interventions to improve detection and modulation of risk biomarkers associated with cancer prevention in these high-risk patients (High-Risk Prevention); and 3) developing and disseminating behavioral, nutritional, and clinical support interventions to address the impact of cancer (Survivorship). The 49 members of CPC come from 23 departments in six schools. They represent a rich mix of expertise, including behavioral science, neuroscience, primary care, nursing, oncology, epidemiology, economics, translational biology, pharmacology, communications, biostatistics, and health services research. Program members are supported by $13.3M in total annual funds, including $3.8M from the National Cancer Institute. Currently, 69% of CPC members are principal investigators on externally funded cancer research grants. CPC program activities support both intra- and inter-programmatic interactions through translational research seminars, a visiting scholar program, and cancer care delivery and equity, tobacco control, implementation science, and health services research working groups. These activities have fostered intra- and inter-programmatic productivity, resulting in 225 articles published by CPC members in 2020, of which 20% had inter-programmatic, 32% had intra- programmatic, and 67% had external collaborations. The work in CPC begins and ends with the needs of the KUCC catchment area. CPC members have shown remarkable success in developing the infrastructure to conduct cancer prevention and control research in our region among rural, African American, Hispanic, and American Indian communities and individuals in the criminal justice system. A strong mentorship program places a significant focus on training. Seven CPC trainees received more than $1.2M in extramural training grant support in 2020 alone; CPC members have demonstrated a 9.2-fold return from CCSG Developmental Funds and a 23.3-fold return from KUCC Pilot Projects. The shared work of CPC members has led to: a better understanding of the cancer control needs in the KUCC catchment area; improved capacity to analyze the needs of affected and at-risk populations; identification of novel pre-cancerous models and new biomarkers; improved strategies to detect and prevent cancer in high-risk patients; better strategies for the design and delivery of cancer prevention and control messages; and improved delivery of tobacco control, cancer screening, physical activity, obesity, and survivorship programs at the level of both the clinical practice and the community-at-large.

癌症预防和控制：摘要堪萨斯大学癌症中心的癌症预防和控制 (CPC) 研究项目 (KUCC) 汇集了一个跨学科的研究人员团队，专注于：1) 开发、测试和实施创新策略来改变导致癌症风险和癌症差异的行为发病率（人群一级预防）； 2) 识别生物标志物驱动的癌症机会患有癌前疾病或遗传性癌症风险的高危人群的预防和检测改善与癌症预防相关的风险生物标志物的检测和调节的干预措施这些高风险患者（高风险预防）； 3) 发展和传播行为、营养、以及临床支持干预措施，以解决癌症的影响（生存）。 49名中共党员来自六所学校的23个系。他们代表了丰富的专业知识，包括行为科学、神经科学、初级保健、护理、肿瘤学、流行病学、经济学、转化生物学、药理学、通信、生物统计学和卫生服务研究。计划成员获得 1,330 万美元的支持年度总资金，包括来自国家癌症研究所的 380 万美元。目前，69%的中共党员外部资助的癌症研究资助的主要研究人员。 CPC 计划活动支持内部以及通过转化研究研讨会、访问学者计划进行的项目间互动，以及癌症护理提供和公平、烟草控制、实施科学和卫生服务研究工作组。这些活动促进了计划内和计划间的生产力，从而实现了 225 2020年中共党员发表的文章，其中20%为程序间文章，32%为程序内文章程序化，67% 有外部合作。 CPC 的工作以 KUCC 流域的需求为起点和终点。中共党员表现在发展基础设施以开展癌症预防和控制研究方面取得了巨大成功该地区的农村、非裔美国人、西班牙裔和美洲印第安人社区和个人刑事司法系统。强有力的指导计划非常注重培训。七中共仅 2020 年，学员就获得了超过 120 万美元的校外培训补助金支持；中共党员有 CCSG 发展基金的回报率为 9.2 倍，KUCC Pilot 的回报率为 23.3 倍项目。中共党员的共同努力使：更好地了解了癌症控制的需求 KUCC 集水区；提高分析受影响和高危人群需求的能力；识别新的癌前模型和新的生物标志物；改进检测和预防策略高危患者的癌症；设计和实施癌症预防和控制的更好策略消息；并改善烟草控制、癌症筛查、体力活动、肥胖和临床实践和整个社区层面的生存计划。